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PFAPA syndrome is not a sporadic disease

Cochard, Marie ; Clet, Johanna ; Le, Lan ; Pillet, Pascal ; Onrubia, Xavier ; Guéron, Thierry ; Faouzi, Mohammed ; Hofer, Michaël

In: Rheumatology, 2010, vol. 49, no. 10, p. 1984-1987

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    Titre
    • PFAPA syndrome is not a sporadic disease
    Auteur
    • Cochard, Marie. Pediatric Rheumatology, Department of Pediatrics, CHUV, Lausanne, Department of Pediatrics, HUG, Geneva, Switzerland, Pediatric Rheumatology, Department of Pediatrics, Hôpital Pellegrin, Bordeaux France, Pediatric Practice, Châtel St-Denis and Centre d'Epidémiologie Clinique, University Hospital Lausanne, Lausanne, Switzerland.
    • Clet, Johanna. Pediatric Rheumatology, Department of Pediatrics, CHUV, Lausanne, Department of Pediatrics, HUG, Geneva, Switzerland, Pediatric Rheumatology, Department of Pediatrics, Hôpital Pellegrin, Bordeaux France, Pediatric Practice, Châtel St-Denis and Centre d'Epidémiologie Clinique, University Hospital Lausanne, Lausanne, Switzerland.
    • Le, Lan. Pediatric Rheumatology, Department of Pediatrics, CHUV, Lausanne, Department of Pediatrics, HUG, Geneva, Switzerland, Pediatric Rheumatology, Department of Pediatrics, Hôpital Pellegrin, Bordeaux France, Pediatric Practice, Châtel St-Denis and Centre d'Epidémiologie Clinique, University Hospital Lausanne, Lausanne, Switzerland.
    • Pillet, Pascal. Pediatric Rheumatology, Department of Pediatrics, CHUV, Lausanne, Department of Pediatrics, HUG, Geneva, Switzerland, Pediatric Rheumatology, Department of Pediatrics, Hôpital Pellegrin, Bordeaux France, Pediatric Practice, Châtel St-Denis and Centre d'Epidémiologie Clinique, University Hospital Lausanne, Lausanne, Switzerland.
    • Onrubia, Xavier. Pediatric Rheumatology, Department of Pediatrics, CHUV, Lausanne, Department of Pediatrics, HUG, Geneva, Switzerland, Pediatric Rheumatology, Department of Pediatrics, Hôpital Pellegrin, Bordeaux France, Pediatric Practice, Châtel St-Denis and Centre d'Epidémiologie Clinique, University Hospital Lausanne, Lausanne, Switzerland.
    • Guéron, Thierry. Pediatric Rheumatology, Department of Pediatrics, CHUV, Lausanne, Department of Pediatrics, HUG, Geneva, Switzerland, Pediatric Rheumatology, Department of Pediatrics, Hôpital Pellegrin, Bordeaux France, Pediatric Practice, Châtel St-Denis and Centre d'Epidémiologie Clinique, University Hospital Lausanne, Lausanne, Switzerland.
    • Faouzi, Mohammed. Pediatric Rheumatology, Department of Pediatrics, CHUV, Lausanne, Department of Pediatrics, HUG, Geneva, Switzerland, Pediatric Rheumatology, Department of Pediatrics, Hôpital Pellegrin, Bordeaux France, Pediatric Practice, Châtel St-Denis and Centre d'Epidémiologie Clinique, University Hospital Lausanne, Lausanne, Switzerland.
    • Hofer, Michaël. Pediatric Rheumatology, Department of Pediatrics, CHUV, Lausanne, Department of Pediatrics, HUG, Geneva, Switzerland, Pediatric Rheumatology, Department of Pediatrics, Hôpital Pellegrin, Bordeaux France, Pediatric Practice, Châtel St-Denis and Centre d'Epidémiologie Clinique, University Hospital Lausanne, Lausanne, Switzerland.
    Type de document
    • Postprint
    Identifiant OAI-PMH
    • oai:doc.rero.ch:299324
    Summary
    Objectives. To determine whether PFAPA (periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis) patients have a positive family history (FH) for recurrent fever syndromes. Method. For all patients with PFAPA seen in two paediatric rheumatology centres (Romandy, Switzerland and Bordeaux, France), parents were interviewed to record the FH for periodic fever. As controls, we interviewed a group of children without history of recurrent fever. Results. We recruited 84 patients with PFAPA and 47 healthy children. The FH for recurrent fever (without an infectious cause and recurring for at least half a year) was positive in 38/84 (45%), and was positive for PFAPA (diagnosis confirmed by a physician) in 10/84 (12%) of the PFAPA patients. For 29 of the 38 patients with positive FH, the affected person was a sibling or a parent. None of the healthy children had a positive FH for recurrent fever or PFAPA. A positive FH for rheumatological diseases was seen in both groups of children. Conclusion. These data show that a significant percentage of PFAPA patients present a positive FH of recurrent fever and PFAPA. This familial susceptibility suggests a potential genetic origin for this syndrome