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ProRule: a new database containing functional and structural information on PROSITE profiles

Sigrist, Christian J. A. ; De Castro, Edouard ; Langendijk-Genevaux, Petra S. ; Le Saux, Virginie ; Bairoch, Amos ; Hulo, Nicolas

In: Bioinformatics, 2005, vol. 21, no. 21, p. 4060-4066

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    Titre
    • ProRule: a new database containing functional and structural information on PROSITE profiles
    Auteur
    • Sigrist, Christian J. A.. *To whom correspondence should be addressed.
    • De Castro, Edouard
    • Langendijk-Genevaux, Petra S.
    • Le Saux, Virginie
    • Bairoch, Amos. Structural Biology and Bioinformatics Department, University of Geneva Geneva, Switzerland
    • Hulo, Nicolas
    Type de document
    • Postprint
    Classification
    • Informatique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:298866
    Summary
    Motivation: Increase the discriminatory power of PROSITE profiles to facilitate function determination and provide biologically relevant information about domains detected by profiles for the annotation of proteins. Summary: We have created a new database, ProRule, which contains additional information about PROSITE profiles. ProRule contains notably the position of structurally and/or functionally critical amino acids, as well as the condition they must fulfill to play their biological role. These supplementary data should help function determination and annotation of the UniProt Swiss-Prot knowledgebase. ProRule also contains information about the domain detected by the profile in the Swiss-Prot line format. Hence, ProRule can be used to make Swiss-Prot annotation more homogeneous and consistent. The format of ProRule can be extended to provide information about combination of domains. Availability: ProRule can be accessed through ScanProsite at http://www.expasy.org/tools/scanprosite. A file containing the rules will be made available under the PROSITE copyright conditions on our ftp site (ftp://www.expasy.org/databases/prosite/) by the next PROSITE release. Contact: christian.sigrist@isb-sib.ch