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HLA Class I and KIR Genes Do Not Protect Against HIV Type 1 Infection in Highly Exposed Uninfected Individuals With Hemophilia A

Vince, Nicolas ; Bashirova, Arman A. ; Lied, Alexandra ; Gao, Xiaojiang ; Dorrell, Lucy ; McLaren, Paul J. ; Fellay, Jacques ; Carrington, Mary

In: The Journal of Infectious Diseases

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    Titre
    • HLA Class I and KIR Genes Do Not Protect Against HIV Type 1 Infection in Highly Exposed Uninfected Individuals With Hemophilia A
    Auteur
    • Vince, Nicolas. Cancer and Inflammation Program, Laboratory of Experimental Immunology, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, Maryland
    • Bashirova, Arman A.. Cancer and Inflammation Program, Laboratory of Experimental Immunology, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, Maryland
    • Lied, Alexandra. Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts
    • Gao, Xiaojiang. Cancer and Inflammation Program, Laboratory of Experimental Immunology, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, Maryland
    • Dorrell, Lucy. Nuffield Department of Medicine, University of Oxford, United Kingdom
    • McLaren, Paul J.. School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne
    • Fellay, Jacques. School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne
    • Carrington, Mary. Cancer and Inflammation Program, Laboratory of Experimental Immunology, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, Maryland
    Type de document
    • Postprint
    Identifiant OAI-PMH
    • oai:doc.rero.ch:298835
    Summary
    A recent genome-wide association study (GWAS) involving patients with hemophilia A who were exposed to but uninfected with human immunodeficiency virus type 1 (HIV-1) did not reveal genetic variants associated with resistance to HIV-1 infection, beyond homozygosity for CCR5-Δ32. Since variation in HLA class I and KIR genes is not well interrogated by standard GWAS techniques, we tested whether these 2 loci were involved in protection from HIV-1 infection in the same hemophilia cohort, using controls from the general population. Our data indicate that HLA class I alleles, presence or absence of KIR genes, and functionally relevant combinations of the HLA/KIR genotypes are not involved in resistance to parenterally transmitted HIV-1 infection