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Pooled Analysis of Prognostic Impact of Urokinase-Type Plasminogen Activator and Its Inhibitor PAI-1 in 8377 Breast Cancer Patients

Look, Maxime P. ; van Putten, Wim L. J. ; Duffy, Michael J. ; Harbeck, Nadia ; Christensen, Ib Jarle ; Thomssen, Christoph ; Kates, Ronald ; Spyratos, Frédérique ; Fernö, Mårten ; Eppenberger-Castori, Serenella ; Sweep, C. G. J. Fred ; Ulm, Kurt ; Peyrat, Jean-Philippe ; Martin, Pierre-Marie ; Magdelenat, Henri ; Brünner, Nils ; Duggan, Catherine ; Lisboa, Björn W. ; Bendahl, Pär-Ola ; Quillien, Véronique ; Daver, Alain ; Ricolleau, Gabriel ; Meijer-van Gelder, Marion E. ; Manders, Peggy ; Fiets, W. Edward ; Blankenstein, Marinus A. ; Broët, Philippe ; Romain, Sylvie ; Daxenbichler, Günter ; Windbichler, Gudrun ; Cufer, Tanja ; Borstnar, Simona ; Kueng, Willy ; Beex, Louk V. A. M. ; Klijn, Jan G. M. ; O'Higgins, Niall ; Eppenberger, Urs ; Jänicke, Fritz ; Schmitt, Manfred ; Foekens, John A.

In: Journal of the National Cancer Institute, 2002, vol. 94, no. 2, p. 116-128

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    Titel
    • Pooled Analysis of Prognostic Impact of Urokinase-Type Plasminogen Activator and Its Inhibitor PAI-1 in 8377 Breast Cancer Patients
    Autor
    • Look, Maxime P.. Affiliations of authors: M. P. Look, M. E. Meijer-van Gelder, J. G. M. Klijn, J. A. Foekens, (Department of Medical Oncology), W. L. J. van Putten (Department of Statistics), Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and University Hospital Rotterdam, The Netherlands; M. J. Duffy, C. Duggan, St. Vincent's University Hospital, Dublin, Ireland; N. Harbeck, R. Kates, K. Ulm, M. Schmitt, Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, Munich, Germany; I. J. Christensen, N. Brünner, Finsen Laboratory, Copenhagen, Denmark; C. Thomssen, B. W. Lisboa, F. Jänicke, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; F. Spyratos, Laboratoire de Biologie Tissulaire, St. Cloud, France; M. Fernö, P. O. Bendahl, Department of Oncology, University Hospital, Lund, Sweden; S. Eppenberger-Castori, W. Kueng, U. Eppenberger, Stiftung Tumorbank Basel, Department of Research, University Hospital of Basel, Switzerland; C. G. J. Sweep, P. Manders, L. V. A. M. Beex, Department of Chemical Endocrinology, University Hospital Nijmegen, The Netherlands; J. P. Peyrat, Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret, Lille, France; P. M. Martin, S. Romain, Laboratoire de Transfert d'Oncologie Biologie, Marseille, France; H. Magdelenat, P. Broët, Institut Curie, Paris, France; V. Quillien, Laboratoire de Biologie, Centre Eugéne Marquis, Rennes, France; A. Daver, Centre Paul Papin, Angers, France; G. Ricolleau, Centre René Gauducheau, St. Herblain, France; W. E. Fiets, M. A. Blankenstein, University Medical Center Utrecht, The Netherlands; G. Daxenbichler, G. Windbichler, Universitätsklinik für Frauenheilkunde, Innsbruck, Austria; T. Cufer, S. Borstnar, Institut of Oncology, Ljubljana, Slovenia; N. O'Higgins, University College Dublin, Ireland.
    • van Putten, Wim L. J.. Affiliations of authors: M. P. Look, M. E. Meijer-van Gelder, J. G. M. Klijn, J. A. Foekens, (Department of Medical Oncology), W. L. J. van Putten (Department of Statistics), Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and University Hospital Rotterdam, The Netherlands; M. J. Duffy, C. Duggan, St. Vincent's University Hospital, Dublin, Ireland; N. Harbeck, R. Kates, K. Ulm, M. Schmitt, Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, Munich, Germany; I. J. Christensen, N. Brünner, Finsen Laboratory, Copenhagen, Denmark; C. Thomssen, B. W. Lisboa, F. Jänicke, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; F. Spyratos, Laboratoire de Biologie Tissulaire, St. Cloud, France; M. Fernö, P. O. Bendahl, Department of Oncology, University Hospital, Lund, Sweden; S. Eppenberger-Castori, W. Kueng, U. Eppenberger, Stiftung Tumorbank Basel, Department of Research, University Hospital of Basel, Switzerland; C. G. J. Sweep, P. Manders, L. V. A. M. Beex, Department of Chemical Endocrinology, University Hospital Nijmegen, The Netherlands; J. P. Peyrat, Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret, Lille, France; P. M. Martin, S. Romain, Laboratoire de Transfert d'Oncologie Biologie, Marseille, France; H. Magdelenat, P. Broët, Institut Curie, Paris, France; V. Quillien, Laboratoire de Biologie, Centre Eugéne Marquis, Rennes, France; A. Daver, Centre Paul Papin, Angers, France; G. Ricolleau, Centre René Gauducheau, St. Herblain, France; W. E. Fiets, M. A. Blankenstein, University Medical Center Utrecht, The Netherlands; G. Daxenbichler, G. Windbichler, Universitätsklinik für Frauenheilkunde, Innsbruck, Austria; T. Cufer, S. Borstnar, Institut of Oncology, Ljubljana, Slovenia; N. O'Higgins, University College Dublin, Ireland.
    • Duffy, Michael J.. Affiliations of authors: M. P. Look, M. E. Meijer-van Gelder, J. G. M. Klijn, J. A. Foekens, (Department of Medical Oncology), W. L. J. van Putten (Department of Statistics), Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and University Hospital Rotterdam, The Netherlands; M. J. Duffy, C. Duggan, St. Vincent's University Hospital, Dublin, Ireland; N. Harbeck, R. Kates, K. Ulm, M. Schmitt, Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, Munich, Germany; I. J. Christensen, N. Brünner, Finsen Laboratory, Copenhagen, Denmark; C. Thomssen, B. W. Lisboa, F. Jänicke, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; F. Spyratos, Laboratoire de Biologie Tissulaire, St. Cloud, France; M. Fernö, P. O. Bendahl, Department of Oncology, University Hospital, Lund, Sweden; S. Eppenberger-Castori, W. Kueng, U. Eppenberger, Stiftung Tumorbank Basel, Department of Research, University Hospital of Basel, Switzerland; C. G. J. Sweep, P. Manders, L. V. A. M. Beex, Department of Chemical Endocrinology, University Hospital Nijmegen, The Netherlands; J. P. Peyrat, Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret, Lille, France; P. M. Martin, S. Romain, Laboratoire de Transfert d'Oncologie Biologie, Marseille, France; H. Magdelenat, P. Broët, Institut Curie, Paris, France; V. Quillien, Laboratoire de Biologie, Centre Eugéne Marquis, Rennes, France; A. Daver, Centre Paul Papin, Angers, France; G. Ricolleau, Centre René Gauducheau, St. Herblain, France; W. E. Fiets, M. A. Blankenstein, University Medical Center Utrecht, The Netherlands; G. Daxenbichler, G. Windbichler, Universitätsklinik für Frauenheilkunde, Innsbruck, Austria; T. Cufer, S. Borstnar, Institut of Oncology, Ljubljana, Slovenia; N. O'Higgins, University College Dublin, Ireland.
    • Harbeck, Nadia. Affiliations of authors: M. P. Look, M. E. Meijer-van Gelder, J. G. M. Klijn, J. A. Foekens, (Department of Medical Oncology), W. L. J. van Putten (Department of Statistics), Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and University Hospital Rotterdam, The Netherlands; M. J. Duffy, C. Duggan, St. Vincent's University Hospital, Dublin, Ireland; N. Harbeck, R. Kates, K. Ulm, M. Schmitt, Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, Munich, Germany; I. J. Christensen, N. Brünner, Finsen Laboratory, Copenhagen, Denmark; C. Thomssen, B. W. Lisboa, F. Jänicke, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; F. Spyratos, Laboratoire de Biologie Tissulaire, St. Cloud, France; M. Fernö, P. O. Bendahl, Department of Oncology, University Hospital, Lund, Sweden; S. Eppenberger-Castori, W. Kueng, U. Eppenberger, Stiftung Tumorbank Basel, Department of Research, University Hospital of Basel, Switzerland; C. G. J. Sweep, P. Manders, L. V. A. M. Beex, Department of Chemical Endocrinology, University Hospital Nijmegen, The Netherlands; J. P. Peyrat, Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret, Lille, France; P. M. Martin, S. Romain, Laboratoire de Transfert d'Oncologie Biologie, Marseille, France; H. Magdelenat, P. Broët, Institut Curie, Paris, France; V. Quillien, Laboratoire de Biologie, Centre Eugéne Marquis, Rennes, France; A. Daver, Centre Paul Papin, Angers, France; G. Ricolleau, Centre René Gauducheau, St. Herblain, France; W. E. Fiets, M. A. Blankenstein, University Medical Center Utrecht, The Netherlands; G. Daxenbichler, G. Windbichler, Universitätsklinik für Frauenheilkunde, Innsbruck, Austria; T. Cufer, S. Borstnar, Institut of Oncology, Ljubljana, Slovenia; N. O'Higgins, University College Dublin, Ireland.
    • Christensen, Ib Jarle. Affiliations of authors: M. P. Look, M. E. Meijer-van Gelder, J. G. M. Klijn, J. A. Foekens, (Department of Medical Oncology), W. L. J. van Putten (Department of Statistics), Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and University Hospital Rotterdam, The Netherlands; M. J. Duffy, C. Duggan, St. Vincent's University Hospital, Dublin, Ireland; N. Harbeck, R. Kates, K. Ulm, M. Schmitt, Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, Munich, Germany; I. J. Christensen, N. Brünner, Finsen Laboratory, Copenhagen, Denmark; C. Thomssen, B. W. Lisboa, F. Jänicke, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; F. Spyratos, Laboratoire de Biologie Tissulaire, St. Cloud, France; M. Fernö, P. O. Bendahl, Department of Oncology, University Hospital, Lund, Sweden; S. Eppenberger-Castori, W. Kueng, U. Eppenberger, Stiftung Tumorbank Basel, Department of Research, University Hospital of Basel, Switzerland; C. G. J. Sweep, P. Manders, L. V. A. M. Beex, Department of Chemical Endocrinology, University Hospital Nijmegen, The Netherlands; J. P. Peyrat, Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret, Lille, France; P. M. Martin, S. Romain, Laboratoire de Transfert d'Oncologie Biologie, Marseille, France; H. Magdelenat, P. Broët, Institut Curie, Paris, France; V. Quillien, Laboratoire de Biologie, Centre Eugéne Marquis, Rennes, France; A. Daver, Centre Paul Papin, Angers, France; G. Ricolleau, Centre René Gauducheau, St. Herblain, France; W. E. Fiets, M. A. Blankenstein, University Medical Center Utrecht, The Netherlands; G. Daxenbichler, G. Windbichler, Universitätsklinik für Frauenheilkunde, Innsbruck, Austria; T. Cufer, S. Borstnar, Institut of Oncology, Ljubljana, Slovenia; N. O'Higgins, University College Dublin, Ireland.
    • Thomssen, Christoph. Affiliations of authors: M. P. Look, M. E. Meijer-van Gelder, J. G. M. Klijn, J. A. Foekens, (Department of Medical Oncology), W. L. J. van Putten (Department of Statistics), Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and University Hospital Rotterdam, The Netherlands; M. J. Duffy, C. Duggan, St. Vincent's University Hospital, Dublin, Ireland; N. Harbeck, R. Kates, K. Ulm, M. Schmitt, Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, Munich, Germany; I. J. Christensen, N. Brünner, Finsen Laboratory, Copenhagen, Denmark; C. Thomssen, B. W. Lisboa, F. Jänicke, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; F. Spyratos, Laboratoire de Biologie Tissulaire, St. Cloud, France; M. Fernö, P. O. Bendahl, Department of Oncology, University Hospital, Lund, Sweden; S. Eppenberger-Castori, W. Kueng, U. Eppenberger, Stiftung Tumorbank Basel, Department of Research, University Hospital of Basel, Switzerland; C. G. J. Sweep, P. Manders, L. V. A. M. Beex, Department of Chemical Endocrinology, University Hospital Nijmegen, The Netherlands; J. P. Peyrat, Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret, Lille, France; P. M. Martin, S. Romain, Laboratoire de Transfert d'Oncologie Biologie, Marseille, France; H. Magdelenat, P. Broët, Institut Curie, Paris, France; V. Quillien, Laboratoire de Biologie, Centre Eugéne Marquis, Rennes, France; A. Daver, Centre Paul Papin, Angers, France; G. Ricolleau, Centre René Gauducheau, St. Herblain, France; W. E. Fiets, M. A. Blankenstein, University Medical Center Utrecht, The Netherlands; G. Daxenbichler, G. Windbichler, Universitätsklinik für Frauenheilkunde, Innsbruck, Austria; T. Cufer, S. Borstnar, Institut of Oncology, Ljubljana, Slovenia; N. O'Higgins, University College Dublin, Ireland.
    • Kates, Ronald. Affiliations of authors: M. P. Look, M. E. Meijer-van Gelder, J. G. M. Klijn, J. A. Foekens, (Department of Medical Oncology), W. L. J. van Putten (Department of Statistics), Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and University Hospital Rotterdam, The Netherlands; M. J. Duffy, C. Duggan, St. Vincent's University Hospital, Dublin, Ireland; N. Harbeck, R. Kates, K. Ulm, M. Schmitt, Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, Munich, Germany; I. J. Christensen, N. Brünner, Finsen Laboratory, Copenhagen, Denmark; C. Thomssen, B. W. Lisboa, F. Jänicke, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; F. Spyratos, Laboratoire de Biologie Tissulaire, St. Cloud, France; M. Fernö, P. O. Bendahl, Department of Oncology, University Hospital, Lund, Sweden; S. Eppenberger-Castori, W. Kueng, U. Eppenberger, Stiftung Tumorbank Basel, Department of Research, University Hospital of Basel, Switzerland; C. G. J. Sweep, P. Manders, L. V. A. M. Beex, Department of Chemical Endocrinology, University Hospital Nijmegen, The Netherlands; J. P. Peyrat, Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret, Lille, France; P. M. Martin, S. Romain, Laboratoire de Transfert d'Oncologie Biologie, Marseille, France; H. Magdelenat, P. Broët, Institut Curie, Paris, France; V. Quillien, Laboratoire de Biologie, Centre Eugéne Marquis, Rennes, France; A. Daver, Centre Paul Papin, Angers, France; G. Ricolleau, Centre René Gauducheau, St. Herblain, France; W. E. Fiets, M. A. Blankenstein, University Medical Center Utrecht, The Netherlands; G. Daxenbichler, G. Windbichler, Universitätsklinik für Frauenheilkunde, Innsbruck, Austria; T. Cufer, S. Borstnar, Institut of Oncology, Ljubljana, Slovenia; N. O'Higgins, University College Dublin, Ireland.
    • Spyratos, Frédérique. Affiliations of authors: M. P. Look, M. E. Meijer-van Gelder, J. G. M. Klijn, J. A. Foekens, (Department of Medical Oncology), W. L. J. van Putten (Department of Statistics), Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and University Hospital Rotterdam, The Netherlands; M. J. Duffy, C. Duggan, St. Vincent's University Hospital, Dublin, Ireland; N. Harbeck, R. Kates, K. Ulm, M. Schmitt, Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, Munich, Germany; I. J. Christensen, N. Brünner, Finsen Laboratory, Copenhagen, Denmark; C. Thomssen, B. W. Lisboa, F. Jänicke, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; F. Spyratos, Laboratoire de Biologie Tissulaire, St. Cloud, France; M. Fernö, P. O. Bendahl, Department of Oncology, University Hospital, Lund, Sweden; S. Eppenberger-Castori, W. Kueng, U. Eppenberger, Stiftung Tumorbank Basel, Department of Research, University Hospital of Basel, Switzerland; C. G. J. Sweep, P. Manders, L. V. A. M. Beex, Department of Chemical Endocrinology, University Hospital Nijmegen, The Netherlands; J. P. Peyrat, Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret, Lille, France; P. M. Martin, S. Romain, Laboratoire de Transfert d'Oncologie Biologie, Marseille, France; H. Magdelenat, P. Broët, Institut Curie, Paris, France; V. Quillien, Laboratoire de Biologie, Centre Eugéne Marquis, Rennes, France; A. Daver, Centre Paul Papin, Angers, France; G. Ricolleau, Centre René Gauducheau, St. Herblain, France; W. E. Fiets, M. A. Blankenstein, University Medical Center Utrecht, The Netherlands; G. Daxenbichler, G. Windbichler, Universitätsklinik für Frauenheilkunde, Innsbruck, Austria; T. Cufer, S. Borstnar, Institut of Oncology, Ljubljana, Slovenia; N. O'Higgins, University College Dublin, Ireland.
    • Fernö, Mårten. Affiliations of authors: M. P. Look, M. E. Meijer-van Gelder, J. G. M. Klijn, J. A. Foekens, (Department of Medical Oncology), W. L. J. van Putten (Department of Statistics), Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and University Hospital Rotterdam, The Netherlands; M. J. Duffy, C. Duggan, St. Vincent's University Hospital, Dublin, Ireland; N. Harbeck, R. Kates, K. Ulm, M. Schmitt, Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, Munich, Germany; I. J. Christensen, N. Brünner, Finsen Laboratory, Copenhagen, Denmark; C. Thomssen, B. W. Lisboa, F. Jänicke, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; F. Spyratos, Laboratoire de Biologie Tissulaire, St. Cloud, France; M. Fernö, P. O. Bendahl, Department of Oncology, University Hospital, Lund, Sweden; S. Eppenberger-Castori, W. Kueng, U. Eppenberger, Stiftung Tumorbank Basel, Department of Research, University Hospital of Basel, Switzerland; C. G. J. Sweep, P. Manders, L. V. A. M. Beex, Department of Chemical Endocrinology, University Hospital Nijmegen, The Netherlands; J. P. Peyrat, Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret, Lille, France; P. M. Martin, S. Romain, Laboratoire de Transfert d'Oncologie Biologie, Marseille, France; H. Magdelenat, P. Broët, Institut Curie, Paris, France; V. Quillien, Laboratoire de Biologie, Centre Eugéne Marquis, Rennes, France; A. Daver, Centre Paul Papin, Angers, France; G. Ricolleau, Centre René Gauducheau, St. Herblain, France; W. E. Fiets, M. A. Blankenstein, University Medical Center Utrecht, The Netherlands; G. Daxenbichler, G. Windbichler, Universitätsklinik für Frauenheilkunde, Innsbruck, Austria; T. Cufer, S. Borstnar, Institut of Oncology, Ljubljana, Slovenia; N. O'Higgins, University College Dublin, Ireland.
    • Eppenberger-Castori, Serenella. Affiliations of authors: M. P. Look, M. E. Meijer-van Gelder, J. G. M. Klijn, J. A. Foekens, (Department of Medical Oncology), W. L. J. van Putten (Department of Statistics), Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and University Hospital Rotterdam, The Netherlands; M. J. Duffy, C. Duggan, St. Vincent's University Hospital, Dublin, Ireland; N. Harbeck, R. Kates, K. Ulm, M. Schmitt, Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, Munich, Germany; I. J. Christensen, N. Brünner, Finsen Laboratory, Copenhagen, Denmark; C. Thomssen, B. W. Lisboa, F. Jänicke, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; F. Spyratos, Laboratoire de Biologie Tissulaire, St. Cloud, France; M. Fernö, P. O. Bendahl, Department of Oncology, University Hospital, Lund, Sweden; S. Eppenberger-Castori, W. Kueng, U. Eppenberger, Stiftung Tumorbank Basel, Department of Research, University Hospital of Basel, Switzerland; C. G. J. Sweep, P. Manders, L. V. A. M. Beex, Department of Chemical Endocrinology, University Hospital Nijmegen, The Netherlands; J. P. Peyrat, Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret, Lille, France; P. M. Martin, S. Romain, Laboratoire de Transfert d'Oncologie Biologie, Marseille, France; H. Magdelenat, P. Broët, Institut Curie, Paris, France; V. Quillien, Laboratoire de Biologie, Centre Eugéne Marquis, Rennes, France; A. Daver, Centre Paul Papin, Angers, France; G. Ricolleau, Centre René Gauducheau, St. Herblain, France; W. E. Fiets, M. A. Blankenstein, University Medical Center Utrecht, The Netherlands; G. Daxenbichler, G. Windbichler, Universitätsklinik für Frauenheilkunde, Innsbruck, Austria; T. Cufer, S. Borstnar, Institut of Oncology, Ljubljana, Slovenia; N. O'Higgins, University College Dublin, Ireland.
    • Sweep, C. G. J. Fred. Affiliations of authors: M. P. Look, M. E. Meijer-van Gelder, J. G. M. Klijn, J. A. Foekens, (Department of Medical Oncology), W. L. J. van Putten (Department of Statistics), Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and University Hospital Rotterdam, The Netherlands; M. J. Duffy, C. Duggan, St. Vincent's University Hospital, Dublin, Ireland; N. Harbeck, R. Kates, K. Ulm, M. Schmitt, Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, Munich, Germany; I. J. Christensen, N. Brünner, Finsen Laboratory, Copenhagen, Denmark; C. Thomssen, B. W. Lisboa, F. Jänicke, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; F. Spyratos, Laboratoire de Biologie Tissulaire, St. Cloud, France; M. Fernö, P. O. Bendahl, Department of Oncology, University Hospital, Lund, Sweden; S. Eppenberger-Castori, W. Kueng, U. Eppenberger, Stiftung Tumorbank Basel, Department of Research, University Hospital of Basel, Switzerland; C. G. J. Sweep, P. Manders, L. V. A. M. Beex, Department of Chemical Endocrinology, University Hospital Nijmegen, The Netherlands; J. P. Peyrat, Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret, Lille, France; P. M. Martin, S. Romain, Laboratoire de Transfert d'Oncologie Biologie, Marseille, France; H. Magdelenat, P. Broët, Institut Curie, Paris, France; V. Quillien, Laboratoire de Biologie, Centre Eugéne Marquis, Rennes, France; A. Daver, Centre Paul Papin, Angers, France; G. Ricolleau, Centre René Gauducheau, St. Herblain, France; W. E. Fiets, M. A. Blankenstein, University Medical Center Utrecht, The Netherlands; G. Daxenbichler, G. Windbichler, Universitätsklinik für Frauenheilkunde, Innsbruck, Austria; T. Cufer, S. Borstnar, Institut of Oncology, Ljubljana, Slovenia; N. O'Higgins, University College Dublin, Ireland.
    • Ulm, Kurt. Affiliations of authors: M. P. Look, M. E. Meijer-van Gelder, J. G. M. Klijn, J. A. Foekens, (Department of Medical Oncology), W. L. J. van Putten (Department of Statistics), Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and University Hospital Rotterdam, The Netherlands; M. J. Duffy, C. Duggan, St. Vincent's University Hospital, Dublin, Ireland; N. Harbeck, R. Kates, K. Ulm, M. Schmitt, Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, Munich, Germany; I. J. Christensen, N. Brünner, Finsen Laboratory, Copenhagen, Denmark; C. Thomssen, B. W. Lisboa, F. Jänicke, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; F. Spyratos, Laboratoire de Biologie Tissulaire, St. Cloud, France; M. Fernö, P. O. Bendahl, Department of Oncology, University Hospital, Lund, Sweden; S. Eppenberger-Castori, W. Kueng, U. Eppenberger, Stiftung Tumorbank Basel, Department of Research, University Hospital of Basel, Switzerland; C. G. J. Sweep, P. Manders, L. V. A. M. Beex, Department of Chemical Endocrinology, University Hospital Nijmegen, The Netherlands; J. P. Peyrat, Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret, Lille, France; P. M. Martin, S. Romain, Laboratoire de Transfert d'Oncologie Biologie, Marseille, France; H. Magdelenat, P. Broët, Institut Curie, Paris, France; V. Quillien, Laboratoire de Biologie, Centre Eugéne Marquis, Rennes, France; A. Daver, Centre Paul Papin, Angers, France; G. Ricolleau, Centre René Gauducheau, St. Herblain, France; W. E. Fiets, M. A. Blankenstein, University Medical Center Utrecht, The Netherlands; G. Daxenbichler, G. Windbichler, Universitätsklinik für Frauenheilkunde, Innsbruck, Austria; T. Cufer, S. Borstnar, Institut of Oncology, Ljubljana, Slovenia; N. O'Higgins, University College Dublin, Ireland.
    • Peyrat, Jean-Philippe. Affiliations of authors: M. P. Look, M. E. Meijer-van Gelder, J. G. M. Klijn, J. A. Foekens, (Department of Medical Oncology), W. L. J. van Putten (Department of Statistics), Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and University Hospital Rotterdam, The Netherlands; M. J. Duffy, C. Duggan, St. Vincent's University Hospital, Dublin, Ireland; N. Harbeck, R. Kates, K. Ulm, M. Schmitt, Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, Munich, Germany; I. J. Christensen, N. Brünner, Finsen Laboratory, Copenhagen, Denmark; C. Thomssen, B. W. Lisboa, F. Jänicke, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; F. Spyratos, Laboratoire de Biologie Tissulaire, St. Cloud, France; M. Fernö, P. O. Bendahl, Department of Oncology, University Hospital, Lund, Sweden; S. Eppenberger-Castori, W. Kueng, U. Eppenberger, Stiftung Tumorbank Basel, Department of Research, University Hospital of Basel, Switzerland; C. G. J. Sweep, P. Manders, L. V. A. M. Beex, Department of Chemical Endocrinology, University Hospital Nijmegen, The Netherlands; J. P. Peyrat, Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret, Lille, France; P. M. Martin, S. Romain, Laboratoire de Transfert d'Oncologie Biologie, Marseille, France; H. Magdelenat, P. Broët, Institut Curie, Paris, France; V. Quillien, Laboratoire de Biologie, Centre Eugéne Marquis, Rennes, France; A. Daver, Centre Paul Papin, Angers, France; G. Ricolleau, Centre René Gauducheau, St. Herblain, France; W. E. Fiets, M. A. Blankenstein, University Medical Center Utrecht, The Netherlands; G. Daxenbichler, G. Windbichler, Universitätsklinik für Frauenheilkunde, Innsbruck, Austria; T. Cufer, S. Borstnar, Institut of Oncology, Ljubljana, Slovenia; N. O'Higgins, University College Dublin, Ireland.
    • Martin, Pierre-Marie. Affiliations of authors: M. P. Look, M. E. Meijer-van Gelder, J. G. M. Klijn, J. A. Foekens, (Department of Medical Oncology), W. L. J. van Putten (Department of Statistics), Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and University Hospital Rotterdam, The Netherlands; M. J. Duffy, C. Duggan, St. Vincent's University Hospital, Dublin, Ireland; N. Harbeck, R. Kates, K. Ulm, M. Schmitt, Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, Munich, Germany; I. J. Christensen, N. Brünner, Finsen Laboratory, Copenhagen, Denmark; C. Thomssen, B. W. Lisboa, F. Jänicke, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; F. Spyratos, Laboratoire de Biologie Tissulaire, St. Cloud, France; M. Fernö, P. O. Bendahl, Department of Oncology, University Hospital, Lund, Sweden; S. Eppenberger-Castori, W. Kueng, U. Eppenberger, Stiftung Tumorbank Basel, Department of Research, University Hospital of Basel, Switzerland; C. G. J. Sweep, P. Manders, L. V. A. M. Beex, Department of Chemical Endocrinology, University Hospital Nijmegen, The Netherlands; J. P. Peyrat, Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret, Lille, France; P. M. Martin, S. Romain, Laboratoire de Transfert d'Oncologie Biologie, Marseille, France; H. Magdelenat, P. Broët, Institut Curie, Paris, France; V. Quillien, Laboratoire de Biologie, Centre Eugéne Marquis, Rennes, France; A. Daver, Centre Paul Papin, Angers, France; G. Ricolleau, Centre René Gauducheau, St. Herblain, France; W. E. Fiets, M. A. Blankenstein, University Medical Center Utrecht, The Netherlands; G. Daxenbichler, G. Windbichler, Universitätsklinik für Frauenheilkunde, Innsbruck, Austria; T. Cufer, S. Borstnar, Institut of Oncology, Ljubljana, Slovenia; N. O'Higgins, University College Dublin, Ireland.
    • Magdelenat, Henri. Affiliations of authors: M. P. Look, M. E. Meijer-van Gelder, J. G. M. Klijn, J. A. Foekens, (Department of Medical Oncology), W. L. J. van Putten (Department of Statistics), Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and University Hospital Rotterdam, The Netherlands; M. J. Duffy, C. Duggan, St. Vincent's University Hospital, Dublin, Ireland; N. Harbeck, R. Kates, K. Ulm, M. Schmitt, Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, Munich, Germany; I. J. Christensen, N. Brünner, Finsen Laboratory, Copenhagen, Denmark; C. Thomssen, B. W. Lisboa, F. Jänicke, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; F. Spyratos, Laboratoire de Biologie Tissulaire, St. Cloud, France; M. Fernö, P. O. Bendahl, Department of Oncology, University Hospital, Lund, Sweden; S. Eppenberger-Castori, W. Kueng, U. Eppenberger, Stiftung Tumorbank Basel, Department of Research, University Hospital of Basel, Switzerland; C. G. J. Sweep, P. Manders, L. V. A. M. Beex, Department of Chemical Endocrinology, University Hospital Nijmegen, The Netherlands; J. P. Peyrat, Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret, Lille, France; P. M. Martin, S. Romain, Laboratoire de Transfert d'Oncologie Biologie, Marseille, France; H. Magdelenat, P. Broët, Institut Curie, Paris, France; V. Quillien, Laboratoire de Biologie, Centre Eugéne Marquis, Rennes, France; A. Daver, Centre Paul Papin, Angers, France; G. Ricolleau, Centre René Gauducheau, St. Herblain, France; W. E. Fiets, M. A. Blankenstein, University Medical Center Utrecht, The Netherlands; G. Daxenbichler, G. Windbichler, Universitätsklinik für Frauenheilkunde, Innsbruck, Austria; T. Cufer, S. Borstnar, Institut of Oncology, Ljubljana, Slovenia; N. O'Higgins, University College Dublin, Ireland.
    • Brünner, Nils. Affiliations of authors: M. P. Look, M. E. Meijer-van Gelder, J. G. M. Klijn, J. A. Foekens, (Department of Medical Oncology), W. L. J. van Putten (Department of Statistics), Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and University Hospital Rotterdam, The Netherlands; M. J. Duffy, C. Duggan, St. Vincent's University Hospital, Dublin, Ireland; N. Harbeck, R. Kates, K. Ulm, M. Schmitt, Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, Munich, Germany; I. J. Christensen, N. Brünner, Finsen Laboratory, Copenhagen, Denmark; C. Thomssen, B. W. Lisboa, F. Jänicke, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; F. Spyratos, Laboratoire de Biologie Tissulaire, St. Cloud, France; M. Fernö, P. O. Bendahl, Department of Oncology, University Hospital, Lund, Sweden; S. Eppenberger-Castori, W. Kueng, U. Eppenberger, Stiftung Tumorbank Basel, Department of Research, University Hospital of Basel, Switzerland; C. G. J. Sweep, P. Manders, L. V. A. M. Beex, Department of Chemical Endocrinology, University Hospital Nijmegen, The Netherlands; J. P. Peyrat, Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret, Lille, France; P. M. Martin, S. Romain, Laboratoire de Transfert d'Oncologie Biologie, Marseille, France; H. Magdelenat, P. Broët, Institut Curie, Paris, France; V. Quillien, Laboratoire de Biologie, Centre Eugéne Marquis, Rennes, France; A. Daver, Centre Paul Papin, Angers, France; G. Ricolleau, Centre René Gauducheau, St. Herblain, France; W. E. Fiets, M. A. Blankenstein, University Medical Center Utrecht, The Netherlands; G. Daxenbichler, G. Windbichler, Universitätsklinik für Frauenheilkunde, Innsbruck, Austria; T. Cufer, S. Borstnar, Institut of Oncology, Ljubljana, Slovenia; N. O'Higgins, University College Dublin, Ireland.
    • Duggan, Catherine. Affiliations of authors: M. P. Look, M. E. Meijer-van Gelder, J. G. M. Klijn, J. A. Foekens, (Department of Medical Oncology), W. L. J. van Putten (Department of Statistics), Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and University Hospital Rotterdam, The Netherlands; M. J. Duffy, C. Duggan, St. Vincent's University Hospital, Dublin, Ireland; N. Harbeck, R. Kates, K. Ulm, M. Schmitt, Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, Munich, Germany; I. J. Christensen, N. Brünner, Finsen Laboratory, Copenhagen, Denmark; C. Thomssen, B. W. Lisboa, F. Jänicke, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; F. Spyratos, Laboratoire de Biologie Tissulaire, St. Cloud, France; M. Fernö, P. O. Bendahl, Department of Oncology, University Hospital, Lund, Sweden; S. Eppenberger-Castori, W. Kueng, U. Eppenberger, Stiftung Tumorbank Basel, Department of Research, University Hospital of Basel, Switzerland; C. G. J. Sweep, P. Manders, L. V. A. M. Beex, Department of Chemical Endocrinology, University Hospital Nijmegen, The Netherlands; J. P. Peyrat, Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret, Lille, France; P. M. Martin, S. Romain, Laboratoire de Transfert d'Oncologie Biologie, Marseille, France; H. Magdelenat, P. Broët, Institut Curie, Paris, France; V. Quillien, Laboratoire de Biologie, Centre Eugéne Marquis, Rennes, France; A. Daver, Centre Paul Papin, Angers, France; G. Ricolleau, Centre René Gauducheau, St. Herblain, France; W. E. Fiets, M. A. Blankenstein, University Medical Center Utrecht, The Netherlands; G. Daxenbichler, G. Windbichler, Universitätsklinik für Frauenheilkunde, Innsbruck, Austria; T. Cufer, S. Borstnar, Institut of Oncology, Ljubljana, Slovenia; N. O'Higgins, University College Dublin, Ireland.
    • Lisboa, Björn W.. Affiliations of authors: M. P. Look, M. E. Meijer-van Gelder, J. G. M. Klijn, J. A. Foekens, (Department of Medical Oncology), W. L. J. van Putten (Department of Statistics), Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and University Hospital Rotterdam, The Netherlands; M. J. Duffy, C. Duggan, St. Vincent's University Hospital, Dublin, Ireland; N. Harbeck, R. Kates, K. Ulm, M. Schmitt, Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, Munich, Germany; I. J. Christensen, N. Brünner, Finsen Laboratory, Copenhagen, Denmark; C. Thomssen, B. W. Lisboa, F. Jänicke, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; F. Spyratos, Laboratoire de Biologie Tissulaire, St. Cloud, France; M. Fernö, P. O. Bendahl, Department of Oncology, University Hospital, Lund, Sweden; S. Eppenberger-Castori, W. Kueng, U. Eppenberger, Stiftung Tumorbank Basel, Department of Research, University Hospital of Basel, Switzerland; C. G. J. Sweep, P. Manders, L. V. A. M. Beex, Department of Chemical Endocrinology, University Hospital Nijmegen, The Netherlands; J. P. Peyrat, Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret, Lille, France; P. M. Martin, S. Romain, Laboratoire de Transfert d'Oncologie Biologie, Marseille, France; H. Magdelenat, P. Broët, Institut Curie, Paris, France; V. Quillien, Laboratoire de Biologie, Centre Eugéne Marquis, Rennes, France; A. Daver, Centre Paul Papin, Angers, France; G. Ricolleau, Centre René Gauducheau, St. Herblain, France; W. E. Fiets, M. A. Blankenstein, University Medical Center Utrecht, The Netherlands; G. Daxenbichler, G. Windbichler, Universitätsklinik für Frauenheilkunde, Innsbruck, Austria; T. Cufer, S. Borstnar, Institut of Oncology, Ljubljana, Slovenia; N. O'Higgins, University College Dublin, Ireland.
    • Bendahl, Pär-Ola. Affiliations of authors: M. P. Look, M. E. Meijer-van Gelder, J. G. M. Klijn, J. A. Foekens, (Department of Medical Oncology), W. L. J. van Putten (Department of Statistics), Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and University Hospital Rotterdam, The Netherlands; M. J. Duffy, C. Duggan, St. Vincent's University Hospital, Dublin, Ireland; N. Harbeck, R. Kates, K. Ulm, M. Schmitt, Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, Munich, Germany; I. J. Christensen, N. Brünner, Finsen Laboratory, Copenhagen, Denmark; C. Thomssen, B. W. Lisboa, F. Jänicke, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; F. Spyratos, Laboratoire de Biologie Tissulaire, St. Cloud, France; M. Fernö, P. O. Bendahl, Department of Oncology, University Hospital, Lund, Sweden; S. Eppenberger-Castori, W. Kueng, U. Eppenberger, Stiftung Tumorbank Basel, Department of Research, University Hospital of Basel, Switzerland; C. G. J. Sweep, P. Manders, L. V. A. M. Beex, Department of Chemical Endocrinology, University Hospital Nijmegen, The Netherlands; J. P. Peyrat, Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret, Lille, France; P. M. Martin, S. Romain, Laboratoire de Transfert d'Oncologie Biologie, Marseille, France; H. Magdelenat, P. Broët, Institut Curie, Paris, France; V. Quillien, Laboratoire de Biologie, Centre Eugéne Marquis, Rennes, France; A. Daver, Centre Paul Papin, Angers, France; G. Ricolleau, Centre René Gauducheau, St. Herblain, France; W. E. Fiets, M. A. Blankenstein, University Medical Center Utrecht, The Netherlands; G. Daxenbichler, G. Windbichler, Universitätsklinik für Frauenheilkunde, Innsbruck, Austria; T. Cufer, S. Borstnar, Institut of Oncology, Ljubljana, Slovenia; N. O'Higgins, University College Dublin, Ireland.
    • Quillien, Véronique. Affiliations of authors: M. P. Look, M. E. Meijer-van Gelder, J. G. M. Klijn, J. A. Foekens, (Department of Medical Oncology), W. L. J. van Putten (Department of Statistics), Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and University Hospital Rotterdam, The Netherlands; M. J. Duffy, C. Duggan, St. Vincent's University Hospital, Dublin, Ireland; N. Harbeck, R. Kates, K. Ulm, M. Schmitt, Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, Munich, Germany; I. J. Christensen, N. Brünner, Finsen Laboratory, Copenhagen, Denmark; C. Thomssen, B. W. Lisboa, F. Jänicke, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; F. Spyratos, Laboratoire de Biologie Tissulaire, St. Cloud, France; M. Fernö, P. O. Bendahl, Department of Oncology, University Hospital, Lund, Sweden; S. Eppenberger-Castori, W. Kueng, U. Eppenberger, Stiftung Tumorbank Basel, Department of Research, University Hospital of Basel, Switzerland; C. G. J. Sweep, P. Manders, L. V. A. M. Beex, Department of Chemical Endocrinology, University Hospital Nijmegen, The Netherlands; J. P. Peyrat, Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret, Lille, France; P. M. Martin, S. Romain, Laboratoire de Transfert d'Oncologie Biologie, Marseille, France; H. Magdelenat, P. Broët, Institut Curie, Paris, France; V. Quillien, Laboratoire de Biologie, Centre Eugéne Marquis, Rennes, France; A. Daver, Centre Paul Papin, Angers, France; G. Ricolleau, Centre René Gauducheau, St. Herblain, France; W. E. Fiets, M. A. Blankenstein, University Medical Center Utrecht, The Netherlands; G. Daxenbichler, G. Windbichler, Universitätsklinik für Frauenheilkunde, Innsbruck, Austria; T. Cufer, S. Borstnar, Institut of Oncology, Ljubljana, Slovenia; N. O'Higgins, University College Dublin, Ireland.
    • Daver, Alain. Affiliations of authors: M. P. Look, M. E. Meijer-van Gelder, J. G. M. Klijn, J. A. Foekens, (Department of Medical Oncology), W. L. J. van Putten (Department of Statistics), Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and University Hospital Rotterdam, The Netherlands; M. J. Duffy, C. Duggan, St. Vincent's University Hospital, Dublin, Ireland; N. Harbeck, R. Kates, K. Ulm, M. Schmitt, Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, Munich, Germany; I. J. Christensen, N. Brünner, Finsen Laboratory, Copenhagen, Denmark; C. Thomssen, B. W. Lisboa, F. Jänicke, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; F. Spyratos, Laboratoire de Biologie Tissulaire, St. Cloud, France; M. Fernö, P. O. Bendahl, Department of Oncology, University Hospital, Lund, Sweden; S. Eppenberger-Castori, W. Kueng, U. Eppenberger, Stiftung Tumorbank Basel, Department of Research, University Hospital of Basel, Switzerland; C. G. J. Sweep, P. Manders, L. V. A. M. Beex, Department of Chemical Endocrinology, University Hospital Nijmegen, The Netherlands; J. P. Peyrat, Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret, Lille, France; P. M. Martin, S. Romain, Laboratoire de Transfert d'Oncologie Biologie, Marseille, France; H. Magdelenat, P. Broët, Institut Curie, Paris, France; V. Quillien, Laboratoire de Biologie, Centre Eugéne Marquis, Rennes, France; A. Daver, Centre Paul Papin, Angers, France; G. Ricolleau, Centre René Gauducheau, St. Herblain, France; W. E. Fiets, M. A. Blankenstein, University Medical Center Utrecht, The Netherlands; G. Daxenbichler, G. Windbichler, Universitätsklinik für Frauenheilkunde, Innsbruck, Austria; T. Cufer, S. Borstnar, Institut of Oncology, Ljubljana, Slovenia; N. O'Higgins, University College Dublin, Ireland.
    • Ricolleau, Gabriel. Affiliations of authors: M. P. Look, M. E. Meijer-van Gelder, J. G. M. Klijn, J. A. Foekens, (Department of Medical Oncology), W. L. J. van Putten (Department of Statistics), Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and University Hospital Rotterdam, The Netherlands; M. J. Duffy, C. Duggan, St. Vincent's University Hospital, Dublin, Ireland; N. Harbeck, R. Kates, K. Ulm, M. Schmitt, Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, Munich, Germany; I. J. Christensen, N. Brünner, Finsen Laboratory, Copenhagen, Denmark; C. Thomssen, B. W. Lisboa, F. Jänicke, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; F. Spyratos, Laboratoire de Biologie Tissulaire, St. Cloud, France; M. Fernö, P. O. Bendahl, Department of Oncology, University Hospital, Lund, Sweden; S. Eppenberger-Castori, W. Kueng, U. Eppenberger, Stiftung Tumorbank Basel, Department of Research, University Hospital of Basel, Switzerland; C. G. J. Sweep, P. Manders, L. V. A. M. Beex, Department of Chemical Endocrinology, University Hospital Nijmegen, The Netherlands; J. P. Peyrat, Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret, Lille, France; P. M. Martin, S. Romain, Laboratoire de Transfert d'Oncologie Biologie, Marseille, France; H. Magdelenat, P. Broët, Institut Curie, Paris, France; V. Quillien, Laboratoire de Biologie, Centre Eugéne Marquis, Rennes, France; A. Daver, Centre Paul Papin, Angers, France; G. Ricolleau, Centre René Gauducheau, St. Herblain, France; W. E. Fiets, M. A. Blankenstein, University Medical Center Utrecht, The Netherlands; G. Daxenbichler, G. Windbichler, Universitätsklinik für Frauenheilkunde, Innsbruck, Austria; T. Cufer, S. Borstnar, Institut of Oncology, Ljubljana, Slovenia; N. O'Higgins, University College Dublin, Ireland.
    • Meijer-van Gelder, Marion E.. Affiliations of authors: M. P. Look, M. E. Meijer-van Gelder, J. G. M. Klijn, J. A. Foekens, (Department of Medical Oncology), W. L. J. van Putten (Department of Statistics), Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and University Hospital Rotterdam, The Netherlands; M. J. Duffy, C. Duggan, St. Vincent's University Hospital, Dublin, Ireland; N. Harbeck, R. Kates, K. Ulm, M. Schmitt, Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, Munich, Germany; I. J. Christensen, N. Brünner, Finsen Laboratory, Copenhagen, Denmark; C. Thomssen, B. W. Lisboa, F. Jänicke, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; F. Spyratos, Laboratoire de Biologie Tissulaire, St. Cloud, France; M. Fernö, P. O. Bendahl, Department of Oncology, University Hospital, Lund, Sweden; S. Eppenberger-Castori, W. Kueng, U. Eppenberger, Stiftung Tumorbank Basel, Department of Research, University Hospital of Basel, Switzerland; C. G. J. Sweep, P. Manders, L. V. A. M. Beex, Department of Chemical Endocrinology, University Hospital Nijmegen, The Netherlands; J. P. Peyrat, Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret, Lille, France; P. M. Martin, S. Romain, Laboratoire de Transfert d'Oncologie Biologie, Marseille, France; H. Magdelenat, P. Broët, Institut Curie, Paris, France; V. Quillien, Laboratoire de Biologie, Centre Eugéne Marquis, Rennes, France; A. Daver, Centre Paul Papin, Angers, France; G. Ricolleau, Centre René Gauducheau, St. Herblain, France; W. E. Fiets, M. A. Blankenstein, University Medical Center Utrecht, The Netherlands; G. Daxenbichler, G. Windbichler, Universitätsklinik für Frauenheilkunde, Innsbruck, Austria; T. Cufer, S. Borstnar, Institut of Oncology, Ljubljana, Slovenia; N. O'Higgins, University College Dublin, Ireland.
    • Manders, Peggy. Affiliations of authors: M. P. Look, M. E. Meijer-van Gelder, J. G. M. Klijn, J. A. Foekens, (Department of Medical Oncology), W. L. J. van Putten (Department of Statistics), Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and University Hospital Rotterdam, The Netherlands; M. J. Duffy, C. Duggan, St. Vincent's University Hospital, Dublin, Ireland; N. Harbeck, R. Kates, K. Ulm, M. Schmitt, Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, Munich, Germany; I. J. Christensen, N. Brünner, Finsen Laboratory, Copenhagen, Denmark; C. Thomssen, B. W. Lisboa, F. Jänicke, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; F. Spyratos, Laboratoire de Biologie Tissulaire, St. Cloud, France; M. Fernö, P. O. Bendahl, Department of Oncology, University Hospital, Lund, Sweden; S. Eppenberger-Castori, W. Kueng, U. Eppenberger, Stiftung Tumorbank Basel, Department of Research, University Hospital of Basel, Switzerland; C. G. J. Sweep, P. Manders, L. V. A. M. Beex, Department of Chemical Endocrinology, University Hospital Nijmegen, The Netherlands; J. P. Peyrat, Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret, Lille, France; P. M. Martin, S. Romain, Laboratoire de Transfert d'Oncologie Biologie, Marseille, France; H. Magdelenat, P. Broët, Institut Curie, Paris, France; V. Quillien, Laboratoire de Biologie, Centre Eugéne Marquis, Rennes, France; A. Daver, Centre Paul Papin, Angers, France; G. Ricolleau, Centre René Gauducheau, St. Herblain, France; W. E. Fiets, M. A. Blankenstein, University Medical Center Utrecht, The Netherlands; G. Daxenbichler, G. Windbichler, Universitätsklinik für Frauenheilkunde, Innsbruck, Austria; T. Cufer, S. Borstnar, Institut of Oncology, Ljubljana, Slovenia; N. O'Higgins, University College Dublin, Ireland.
    • Fiets, W. Edward. Affiliations of authors: M. P. Look, M. E. Meijer-van Gelder, J. G. M. Klijn, J. A. Foekens, (Department of Medical Oncology), W. L. J. van Putten (Department of Statistics), Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and University Hospital Rotterdam, The Netherlands; M. J. Duffy, C. Duggan, St. Vincent's University Hospital, Dublin, Ireland; N. Harbeck, R. Kates, K. Ulm, M. Schmitt, Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, Munich, Germany; I. J. Christensen, N. Brünner, Finsen Laboratory, Copenhagen, Denmark; C. Thomssen, B. W. Lisboa, F. Jänicke, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; F. Spyratos, Laboratoire de Biologie Tissulaire, St. Cloud, France; M. Fernö, P. O. Bendahl, Department of Oncology, University Hospital, Lund, Sweden; S. Eppenberger-Castori, W. Kueng, U. Eppenberger, Stiftung Tumorbank Basel, Department of Research, University Hospital of Basel, Switzerland; C. G. J. Sweep, P. Manders, L. V. A. M. Beex, Department of Chemical Endocrinology, University Hospital Nijmegen, The Netherlands; J. P. Peyrat, Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret, Lille, France; P. M. Martin, S. Romain, Laboratoire de Transfert d'Oncologie Biologie, Marseille, France; H. Magdelenat, P. Broët, Institut Curie, Paris, France; V. Quillien, Laboratoire de Biologie, Centre Eugéne Marquis, Rennes, France; A. Daver, Centre Paul Papin, Angers, France; G. Ricolleau, Centre René Gauducheau, St. Herblain, France; W. E. Fiets, M. A. Blankenstein, University Medical Center Utrecht, The Netherlands; G. Daxenbichler, G. Windbichler, Universitätsklinik für Frauenheilkunde, Innsbruck, Austria; T. Cufer, S. Borstnar, Institut of Oncology, Ljubljana, Slovenia; N. O'Higgins, University College Dublin, Ireland.
    • Blankenstein, Marinus A.. Affiliations of authors: M. P. Look, M. E. Meijer-van Gelder, J. G. M. Klijn, J. A. Foekens, (Department of Medical Oncology), W. L. J. van Putten (Department of Statistics), Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and University Hospital Rotterdam, The Netherlands; M. J. Duffy, C. Duggan, St. Vincent's University Hospital, Dublin, Ireland; N. Harbeck, R. Kates, K. Ulm, M. Schmitt, Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, Munich, Germany; I. J. Christensen, N. Brünner, Finsen Laboratory, Copenhagen, Denmark; C. Thomssen, B. W. Lisboa, F. Jänicke, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; F. Spyratos, Laboratoire de Biologie Tissulaire, St. Cloud, France; M. Fernö, P. O. Bendahl, Department of Oncology, University Hospital, Lund, Sweden; S. Eppenberger-Castori, W. Kueng, U. Eppenberger, Stiftung Tumorbank Basel, Department of Research, University Hospital of Basel, Switzerland; C. G. J. Sweep, P. Manders, L. V. A. M. Beex, Department of Chemical Endocrinology, University Hospital Nijmegen, The Netherlands; J. P. Peyrat, Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret, Lille, France; P. M. Martin, S. Romain, Laboratoire de Transfert d'Oncologie Biologie, Marseille, France; H. Magdelenat, P. Broët, Institut Curie, Paris, France; V. Quillien, Laboratoire de Biologie, Centre Eugéne Marquis, Rennes, France; A. Daver, Centre Paul Papin, Angers, France; G. Ricolleau, Centre René Gauducheau, St. Herblain, France; W. E. Fiets, M. A. Blankenstein, University Medical Center Utrecht, The Netherlands; G. Daxenbichler, G. Windbichler, Universitätsklinik für Frauenheilkunde, Innsbruck, Austria; T. Cufer, S. Borstnar, Institut of Oncology, Ljubljana, Slovenia; N. O'Higgins, University College Dublin, Ireland.
    • Broët, Philippe. Affiliations of authors: M. P. Look, M. E. Meijer-van Gelder, J. G. M. Klijn, J. A. Foekens, (Department of Medical Oncology), W. L. J. van Putten (Department of Statistics), Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and University Hospital Rotterdam, The Netherlands; M. J. Duffy, C. Duggan, St. Vincent's University Hospital, Dublin, Ireland; N. Harbeck, R. Kates, K. Ulm, M. Schmitt, Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, Munich, Germany; I. J. Christensen, N. Brünner, Finsen Laboratory, Copenhagen, Denmark; C. Thomssen, B. W. Lisboa, F. Jänicke, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; F. Spyratos, Laboratoire de Biologie Tissulaire, St. Cloud, France; M. Fernö, P. O. Bendahl, Department of Oncology, University Hospital, Lund, Sweden; S. Eppenberger-Castori, W. Kueng, U. Eppenberger, Stiftung Tumorbank Basel, Department of Research, University Hospital of Basel, Switzerland; C. G. J. Sweep, P. Manders, L. V. A. M. Beex, Department of Chemical Endocrinology, University Hospital Nijmegen, The Netherlands; J. P. Peyrat, Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret, Lille, France; P. M. Martin, S. Romain, Laboratoire de Transfert d'Oncologie Biologie, Marseille, France; H. Magdelenat, P. Broët, Institut Curie, Paris, France; V. Quillien, Laboratoire de Biologie, Centre Eugéne Marquis, Rennes, France; A. Daver, Centre Paul Papin, Angers, France; G. Ricolleau, Centre René Gauducheau, St. Herblain, France; W. E. Fiets, M. A. Blankenstein, University Medical Center Utrecht, The Netherlands; G. Daxenbichler, G. Windbichler, Universitätsklinik für Frauenheilkunde, Innsbruck, Austria; T. Cufer, S. Borstnar, Institut of Oncology, Ljubljana, Slovenia; N. O'Higgins, University College Dublin, Ireland.
    • Romain, Sylvie. Affiliations of authors: M. P. Look, M. E. Meijer-van Gelder, J. G. M. Klijn, J. A. Foekens, (Department of Medical Oncology), W. L. J. van Putten (Department of Statistics), Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and University Hospital Rotterdam, The Netherlands; M. J. Duffy, C. Duggan, St. Vincent's University Hospital, Dublin, Ireland; N. Harbeck, R. Kates, K. Ulm, M. Schmitt, Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, Munich, Germany; I. J. Christensen, N. Brünner, Finsen Laboratory, Copenhagen, Denmark; C. Thomssen, B. W. Lisboa, F. Jänicke, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; F. Spyratos, Laboratoire de Biologie Tissulaire, St. Cloud, France; M. Fernö, P. O. Bendahl, Department of Oncology, University Hospital, Lund, Sweden; S. Eppenberger-Castori, W. Kueng, U. Eppenberger, Stiftung Tumorbank Basel, Department of Research, University Hospital of Basel, Switzerland; C. G. J. Sweep, P. Manders, L. V. A. M. Beex, Department of Chemical Endocrinology, University Hospital Nijmegen, The Netherlands; J. P. Peyrat, Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret, Lille, France; P. M. Martin, S. Romain, Laboratoire de Transfert d'Oncologie Biologie, Marseille, France; H. Magdelenat, P. Broët, Institut Curie, Paris, France; V. Quillien, Laboratoire de Biologie, Centre Eugéne Marquis, Rennes, France; A. Daver, Centre Paul Papin, Angers, France; G. Ricolleau, Centre René Gauducheau, St. Herblain, France; W. E. Fiets, M. A. Blankenstein, University Medical Center Utrecht, The Netherlands; G. Daxenbichler, G. Windbichler, Universitätsklinik für Frauenheilkunde, Innsbruck, Austria; T. Cufer, S. Borstnar, Institut of Oncology, Ljubljana, Slovenia; N. O'Higgins, University College Dublin, Ireland.
    • Daxenbichler, Günter. Affiliations of authors: M. P. Look, M. E. Meijer-van Gelder, J. G. M. Klijn, J. A. Foekens, (Department of Medical Oncology), W. L. J. van Putten (Department of Statistics), Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and University Hospital Rotterdam, The Netherlands; M. J. Duffy, C. Duggan, St. Vincent's University Hospital, Dublin, Ireland; N. Harbeck, R. Kates, K. Ulm, M. Schmitt, Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, Munich, Germany; I. J. Christensen, N. Brünner, Finsen Laboratory, Copenhagen, Denmark; C. Thomssen, B. W. Lisboa, F. Jänicke, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; F. Spyratos, Laboratoire de Biologie Tissulaire, St. Cloud, France; M. Fernö, P. O. Bendahl, Department of Oncology, University Hospital, Lund, Sweden; S. Eppenberger-Castori, W. Kueng, U. Eppenberger, Stiftung Tumorbank Basel, Department of Research, University Hospital of Basel, Switzerland; C. G. J. Sweep, P. Manders, L. V. A. M. Beex, Department of Chemical Endocrinology, University Hospital Nijmegen, The Netherlands; J. P. Peyrat, Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret, Lille, France; P. M. Martin, S. Romain, Laboratoire de Transfert d'Oncologie Biologie, Marseille, France; H. Magdelenat, P. Broët, Institut Curie, Paris, France; V. Quillien, Laboratoire de Biologie, Centre Eugéne Marquis, Rennes, France; A. Daver, Centre Paul Papin, Angers, France; G. Ricolleau, Centre René Gauducheau, St. Herblain, France; W. E. Fiets, M. A. Blankenstein, University Medical Center Utrecht, The Netherlands; G. Daxenbichler, G. Windbichler, Universitätsklinik für Frauenheilkunde, Innsbruck, Austria; T. Cufer, S. Borstnar, Institut of Oncology, Ljubljana, Slovenia; N. O'Higgins, University College Dublin, Ireland.
    • Windbichler, Gudrun. Affiliations of authors: M. P. Look, M. E. Meijer-van Gelder, J. G. M. Klijn, J. A. Foekens, (Department of Medical Oncology), W. L. J. van Putten (Department of Statistics), Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and University Hospital Rotterdam, The Netherlands; M. J. Duffy, C. Duggan, St. Vincent's University Hospital, Dublin, Ireland; N. Harbeck, R. Kates, K. Ulm, M. Schmitt, Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, Munich, Germany; I. J. Christensen, N. Brünner, Finsen Laboratory, Copenhagen, Denmark; C. Thomssen, B. W. Lisboa, F. Jänicke, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; F. Spyratos, Laboratoire de Biologie Tissulaire, St. Cloud, France; M. Fernö, P. O. Bendahl, Department of Oncology, University Hospital, Lund, Sweden; S. Eppenberger-Castori, W. Kueng, U. Eppenberger, Stiftung Tumorbank Basel, Department of Research, University Hospital of Basel, Switzerland; C. G. J. Sweep, P. Manders, L. V. A. M. Beex, Department of Chemical Endocrinology, University Hospital Nijmegen, The Netherlands; J. P. Peyrat, Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret, Lille, France; P. M. Martin, S. Romain, Laboratoire de Transfert d'Oncologie Biologie, Marseille, France; H. Magdelenat, P. Broët, Institut Curie, Paris, France; V. Quillien, Laboratoire de Biologie, Centre Eugéne Marquis, Rennes, France; A. Daver, Centre Paul Papin, Angers, France; G. Ricolleau, Centre René Gauducheau, St. Herblain, France; W. E. Fiets, M. A. Blankenstein, University Medical Center Utrecht, The Netherlands; G. Daxenbichler, G. Windbichler, Universitätsklinik für Frauenheilkunde, Innsbruck, Austria; T. Cufer, S. Borstnar, Institut of Oncology, Ljubljana, Slovenia; N. O'Higgins, University College Dublin, Ireland.
    • Cufer, Tanja. Affiliations of authors: M. P. Look, M. E. Meijer-van Gelder, J. G. M. Klijn, J. A. Foekens, (Department of Medical Oncology), W. L. J. van Putten (Department of Statistics), Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and University Hospital Rotterdam, The Netherlands; M. J. Duffy, C. Duggan, St. Vincent's University Hospital, Dublin, Ireland; N. Harbeck, R. Kates, K. Ulm, M. Schmitt, Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, Munich, Germany; I. J. Christensen, N. Brünner, Finsen Laboratory, Copenhagen, Denmark; C. Thomssen, B. W. Lisboa, F. Jänicke, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; F. Spyratos, Laboratoire de Biologie Tissulaire, St. Cloud, France; M. Fernö, P. O. Bendahl, Department of Oncology, University Hospital, Lund, Sweden; S. Eppenberger-Castori, W. Kueng, U. Eppenberger, Stiftung Tumorbank Basel, Department of Research, University Hospital of Basel, Switzerland; C. G. J. Sweep, P. Manders, L. V. A. M. Beex, Department of Chemical Endocrinology, University Hospital Nijmegen, The Netherlands; J. P. Peyrat, Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret, Lille, France; P. M. Martin, S. Romain, Laboratoire de Transfert d'Oncologie Biologie, Marseille, France; H. Magdelenat, P. Broët, Institut Curie, Paris, France; V. Quillien, Laboratoire de Biologie, Centre Eugéne Marquis, Rennes, France; A. Daver, Centre Paul Papin, Angers, France; G. Ricolleau, Centre René Gauducheau, St. Herblain, France; W. E. Fiets, M. A. Blankenstein, University Medical Center Utrecht, The Netherlands; G. Daxenbichler, G. Windbichler, Universitätsklinik für Frauenheilkunde, Innsbruck, Austria; T. Cufer, S. Borstnar, Institut of Oncology, Ljubljana, Slovenia; N. O'Higgins, University College Dublin, Ireland.
    • Borstnar, Simona. Affiliations of authors: M. P. Look, M. E. Meijer-van Gelder, J. G. M. Klijn, J. A. Foekens, (Department of Medical Oncology), W. L. J. van Putten (Department of Statistics), Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and University Hospital Rotterdam, The Netherlands; M. J. Duffy, C. Duggan, St. Vincent's University Hospital, Dublin, Ireland; N. Harbeck, R. Kates, K. Ulm, M. Schmitt, Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, Munich, Germany; I. J. Christensen, N. Brünner, Finsen Laboratory, Copenhagen, Denmark; C. Thomssen, B. W. Lisboa, F. Jänicke, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; F. Spyratos, Laboratoire de Biologie Tissulaire, St. Cloud, France; M. Fernö, P. O. Bendahl, Department of Oncology, University Hospital, Lund, Sweden; S. Eppenberger-Castori, W. Kueng, U. Eppenberger, Stiftung Tumorbank Basel, Department of Research, University Hospital of Basel, Switzerland; C. G. J. Sweep, P. Manders, L. V. A. M. Beex, Department of Chemical Endocrinology, University Hospital Nijmegen, The Netherlands; J. P. Peyrat, Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret, Lille, France; P. M. Martin, S. Romain, Laboratoire de Transfert d'Oncologie Biologie, Marseille, France; H. Magdelenat, P. Broët, Institut Curie, Paris, France; V. Quillien, Laboratoire de Biologie, Centre Eugéne Marquis, Rennes, France; A. Daver, Centre Paul Papin, Angers, France; G. Ricolleau, Centre René Gauducheau, St. Herblain, France; W. E. Fiets, M. A. Blankenstein, University Medical Center Utrecht, The Netherlands; G. Daxenbichler, G. Windbichler, Universitätsklinik für Frauenheilkunde, Innsbruck, Austria; T. Cufer, S. Borstnar, Institut of Oncology, Ljubljana, Slovenia; N. O'Higgins, University College Dublin, Ireland.
    • Kueng, Willy. Affiliations of authors: M. P. Look, M. E. Meijer-van Gelder, J. G. M. Klijn, J. A. Foekens, (Department of Medical Oncology), W. L. J. van Putten (Department of Statistics), Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and University Hospital Rotterdam, The Netherlands; M. J. Duffy, C. Duggan, St. Vincent's University Hospital, Dublin, Ireland; N. Harbeck, R. Kates, K. Ulm, M. Schmitt, Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, Munich, Germany; I. J. Christensen, N. Brünner, Finsen Laboratory, Copenhagen, Denmark; C. Thomssen, B. W. Lisboa, F. Jänicke, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; F. Spyratos, Laboratoire de Biologie Tissulaire, St. Cloud, France; M. Fernö, P. O. Bendahl, Department of Oncology, University Hospital, Lund, Sweden; S. Eppenberger-Castori, W. Kueng, U. Eppenberger, Stiftung Tumorbank Basel, Department of Research, University Hospital of Basel, Switzerland; C. G. J. Sweep, P. Manders, L. V. A. M. Beex, Department of Chemical Endocrinology, University Hospital Nijmegen, The Netherlands; J. P. Peyrat, Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret, Lille, France; P. M. Martin, S. Romain, Laboratoire de Transfert d'Oncologie Biologie, Marseille, France; H. Magdelenat, P. Broët, Institut Curie, Paris, France; V. Quillien, Laboratoire de Biologie, Centre Eugéne Marquis, Rennes, France; A. Daver, Centre Paul Papin, Angers, France; G. Ricolleau, Centre René Gauducheau, St. Herblain, France; W. E. Fiets, M. A. Blankenstein, University Medical Center Utrecht, The Netherlands; G. Daxenbichler, G. Windbichler, Universitätsklinik für Frauenheilkunde, Innsbruck, Austria; T. Cufer, S. Borstnar, Institut of Oncology, Ljubljana, Slovenia; N. O'Higgins, University College Dublin, Ireland.
    • Beex, Louk V. A. M.. Affiliations of authors: M. P. Look, M. E. Meijer-van Gelder, J. G. M. Klijn, J. A. Foekens, (Department of Medical Oncology), W. L. J. van Putten (Department of Statistics), Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and University Hospital Rotterdam, The Netherlands; M. J. Duffy, C. Duggan, St. Vincent's University Hospital, Dublin, Ireland; N. Harbeck, R. Kates, K. Ulm, M. Schmitt, Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, Munich, Germany; I. J. Christensen, N. Brünner, Finsen Laboratory, Copenhagen, Denmark; C. Thomssen, B. W. Lisboa, F. Jänicke, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; F. Spyratos, Laboratoire de Biologie Tissulaire, St. Cloud, France; M. Fernö, P. O. Bendahl, Department of Oncology, University Hospital, Lund, Sweden; S. Eppenberger-Castori, W. Kueng, U. Eppenberger, Stiftung Tumorbank Basel, Department of Research, University Hospital of Basel, Switzerland; C. G. J. Sweep, P. Manders, L. V. A. M. Beex, Department of Chemical Endocrinology, University Hospital Nijmegen, The Netherlands; J. P. Peyrat, Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret, Lille, France; P. M. Martin, S. Romain, Laboratoire de Transfert d'Oncologie Biologie, Marseille, France; H. Magdelenat, P. Broët, Institut Curie, Paris, France; V. Quillien, Laboratoire de Biologie, Centre Eugéne Marquis, Rennes, France; A. Daver, Centre Paul Papin, Angers, France; G. Ricolleau, Centre René Gauducheau, St. Herblain, France; W. E. Fiets, M. A. Blankenstein, University Medical Center Utrecht, The Netherlands; G. Daxenbichler, G. Windbichler, Universitätsklinik für Frauenheilkunde, Innsbruck, Austria; T. Cufer, S. Borstnar, Institut of Oncology, Ljubljana, Slovenia; N. O'Higgins, University College Dublin, Ireland.
    • Klijn, Jan G. M.. Affiliations of authors: M. P. Look, M. E. Meijer-van Gelder, J. G. M. Klijn, J. A. Foekens, (Department of Medical Oncology), W. L. J. van Putten (Department of Statistics), Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and University Hospital Rotterdam, The Netherlands; M. J. Duffy, C. Duggan, St. Vincent's University Hospital, Dublin, Ireland; N. Harbeck, R. Kates, K. Ulm, M. Schmitt, Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, Munich, Germany; I. J. Christensen, N. Brünner, Finsen Laboratory, Copenhagen, Denmark; C. Thomssen, B. W. Lisboa, F. Jänicke, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; F. Spyratos, Laboratoire de Biologie Tissulaire, St. Cloud, France; M. Fernö, P. O. Bendahl, Department of Oncology, University Hospital, Lund, Sweden; S. Eppenberger-Castori, W. Kueng, U. Eppenberger, Stiftung Tumorbank Basel, Department of Research, University Hospital of Basel, Switzerland; C. G. J. Sweep, P. Manders, L. V. A. M. Beex, Department of Chemical Endocrinology, University Hospital Nijmegen, The Netherlands; J. P. Peyrat, Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret, Lille, France; P. M. Martin, S. Romain, Laboratoire de Transfert d'Oncologie Biologie, Marseille, France; H. Magdelenat, P. Broët, Institut Curie, Paris, France; V. Quillien, Laboratoire de Biologie, Centre Eugéne Marquis, Rennes, France; A. Daver, Centre Paul Papin, Angers, France; G. Ricolleau, Centre René Gauducheau, St. Herblain, France; W. E. Fiets, M. A. Blankenstein, University Medical Center Utrecht, The Netherlands; G. Daxenbichler, G. Windbichler, Universitätsklinik für Frauenheilkunde, Innsbruck, Austria; T. Cufer, S. Borstnar, Institut of Oncology, Ljubljana, Slovenia; N. O'Higgins, University College Dublin, Ireland.
    • O'Higgins, Niall. Affiliations of authors: M. P. Look, M. E. Meijer-van Gelder, J. G. M. Klijn, J. A. Foekens, (Department of Medical Oncology), W. L. J. van Putten (Department of Statistics), Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and University Hospital Rotterdam, The Netherlands; M. J. Duffy, C. Duggan, St. Vincent's University Hospital, Dublin, Ireland; N. Harbeck, R. Kates, K. Ulm, M. Schmitt, Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, Munich, Germany; I. J. Christensen, N. Brünner, Finsen Laboratory, Copenhagen, Denmark; C. Thomssen, B. W. Lisboa, F. Jänicke, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; F. Spyratos, Laboratoire de Biologie Tissulaire, St. Cloud, France; M. Fernö, P. O. Bendahl, Department of Oncology, University Hospital, Lund, Sweden; S. Eppenberger-Castori, W. Kueng, U. Eppenberger, Stiftung Tumorbank Basel, Department of Research, University Hospital of Basel, Switzerland; C. G. J. Sweep, P. Manders, L. V. A. M. Beex, Department of Chemical Endocrinology, University Hospital Nijmegen, The Netherlands; J. P. Peyrat, Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret, Lille, France; P. M. Martin, S. Romain, Laboratoire de Transfert d'Oncologie Biologie, Marseille, France; H. Magdelenat, P. Broët, Institut Curie, Paris, France; V. Quillien, Laboratoire de Biologie, Centre Eugéne Marquis, Rennes, France; A. Daver, Centre Paul Papin, Angers, France; G. Ricolleau, Centre René Gauducheau, St. Herblain, France; W. E. Fiets, M. A. Blankenstein, University Medical Center Utrecht, The Netherlands; G. Daxenbichler, G. Windbichler, Universitätsklinik für Frauenheilkunde, Innsbruck, Austria; T. Cufer, S. Borstnar, Institut of Oncology, Ljubljana, Slovenia; N. O'Higgins, University College Dublin, Ireland.
    • Eppenberger, Urs. Affiliations of authors: M. P. Look, M. E. Meijer-van Gelder, J. G. M. Klijn, J. A. Foekens, (Department of Medical Oncology), W. L. J. van Putten (Department of Statistics), Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and University Hospital Rotterdam, The Netherlands; M. J. Duffy, C. Duggan, St. Vincent's University Hospital, Dublin, Ireland; N. Harbeck, R. Kates, K. Ulm, M. Schmitt, Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, Munich, Germany; I. J. Christensen, N. Brünner, Finsen Laboratory, Copenhagen, Denmark; C. Thomssen, B. W. Lisboa, F. Jänicke, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; F. Spyratos, Laboratoire de Biologie Tissulaire, St. Cloud, France; M. Fernö, P. O. Bendahl, Department of Oncology, University Hospital, Lund, Sweden; S. Eppenberger-Castori, W. Kueng, U. Eppenberger, Stiftung Tumorbank Basel, Department of Research, University Hospital of Basel, Switzerland; C. G. J. Sweep, P. Manders, L. V. A. M. Beex, Department of Chemical Endocrinology, University Hospital Nijmegen, The Netherlands; J. P. Peyrat, Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret, Lille, France; P. M. Martin, S. Romain, Laboratoire de Transfert d'Oncologie Biologie, Marseille, France; H. Magdelenat, P. Broët, Institut Curie, Paris, France; V. Quillien, Laboratoire de Biologie, Centre Eugéne Marquis, Rennes, France; A. Daver, Centre Paul Papin, Angers, France; G. Ricolleau, Centre René Gauducheau, St. Herblain, France; W. E. Fiets, M. A. Blankenstein, University Medical Center Utrecht, The Netherlands; G. Daxenbichler, G. Windbichler, Universitätsklinik für Frauenheilkunde, Innsbruck, Austria; T. Cufer, S. Borstnar, Institut of Oncology, Ljubljana, Slovenia; N. O'Higgins, University College Dublin, Ireland.
    • Jänicke, Fritz. Affiliations of authors: M. P. Look, M. E. Meijer-van Gelder, J. G. M. Klijn, J. A. Foekens, (Department of Medical Oncology), W. L. J. van Putten (Department of Statistics), Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and University Hospital Rotterdam, The Netherlands; M. J. Duffy, C. Duggan, St. Vincent's University Hospital, Dublin, Ireland; N. Harbeck, R. Kates, K. Ulm, M. Schmitt, Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, Munich, Germany; I. J. Christensen, N. Brünner, Finsen Laboratory, Copenhagen, Denmark; C. Thomssen, B. W. Lisboa, F. Jänicke, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; F. Spyratos, Laboratoire de Biologie Tissulaire, St. Cloud, France; M. Fernö, P. O. Bendahl, Department of Oncology, University Hospital, Lund, Sweden; S. Eppenberger-Castori, W. Kueng, U. Eppenberger, Stiftung Tumorbank Basel, Department of Research, University Hospital of Basel, Switzerland; C. G. J. Sweep, P. Manders, L. V. A. M. Beex, Department of Chemical Endocrinology, University Hospital Nijmegen, The Netherlands; J. P. Peyrat, Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret, Lille, France; P. M. Martin, S. Romain, Laboratoire de Transfert d'Oncologie Biologie, Marseille, France; H. Magdelenat, P. Broët, Institut Curie, Paris, France; V. Quillien, Laboratoire de Biologie, Centre Eugéne Marquis, Rennes, France; A. Daver, Centre Paul Papin, Angers, France; G. Ricolleau, Centre René Gauducheau, St. Herblain, France; W. E. Fiets, M. A. Blankenstein, University Medical Center Utrecht, The Netherlands; G. Daxenbichler, G. Windbichler, Universitätsklinik für Frauenheilkunde, Innsbruck, Austria; T. Cufer, S. Borstnar, Institut of Oncology, Ljubljana, Slovenia; N. O'Higgins, University College Dublin, Ireland.
    • Schmitt, Manfred. Affiliations of authors: M. P. Look, M. E. Meijer-van Gelder, J. G. M. Klijn, J. A. Foekens, (Department of Medical Oncology), W. L. J. van Putten (Department of Statistics), Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and University Hospital Rotterdam, The Netherlands; M. J. Duffy, C. Duggan, St. Vincent's University Hospital, Dublin, Ireland; N. Harbeck, R. Kates, K. Ulm, M. Schmitt, Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, Munich, Germany; I. J. Christensen, N. Brünner, Finsen Laboratory, Copenhagen, Denmark; C. Thomssen, B. W. Lisboa, F. Jänicke, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; F. Spyratos, Laboratoire de Biologie Tissulaire, St. Cloud, France; M. Fernö, P. O. Bendahl, Department of Oncology, University Hospital, Lund, Sweden; S. Eppenberger-Castori, W. Kueng, U. Eppenberger, Stiftung Tumorbank Basel, Department of Research, University Hospital of Basel, Switzerland; C. G. J. Sweep, P. Manders, L. V. A. M. Beex, Department of Chemical Endocrinology, University Hospital Nijmegen, The Netherlands; J. P. Peyrat, Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret, Lille, France; P. M. Martin, S. Romain, Laboratoire de Transfert d'Oncologie Biologie, Marseille, France; H. Magdelenat, P. Broët, Institut Curie, Paris, France; V. Quillien, Laboratoire de Biologie, Centre Eugéne Marquis, Rennes, France; A. Daver, Centre Paul Papin, Angers, France; G. Ricolleau, Centre René Gauducheau, St. Herblain, France; W. E. Fiets, M. A. Blankenstein, University Medical Center Utrecht, The Netherlands; G. Daxenbichler, G. Windbichler, Universitätsklinik für Frauenheilkunde, Innsbruck, Austria; T. Cufer, S. Borstnar, Institut of Oncology, Ljubljana, Slovenia; N. O'Higgins, University College Dublin, Ireland.
    • Foekens, John A.. Affiliations of authors: M. P. Look, M. E. Meijer-van Gelder, J. G. M. Klijn, J. A. Foekens, (Department of Medical Oncology), W. L. J. van Putten (Department of Statistics), Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and University Hospital Rotterdam, The Netherlands; M. J. Duffy, C. Duggan, St. Vincent's University Hospital, Dublin, Ireland; N. Harbeck, R. Kates, K. Ulm, M. Schmitt, Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, Munich, Germany; I. J. Christensen, N. Brünner, Finsen Laboratory, Copenhagen, Denmark; C. Thomssen, B. W. Lisboa, F. Jänicke, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; F. Spyratos, Laboratoire de Biologie Tissulaire, St. Cloud, France; M. Fernö, P. O. Bendahl, Department of Oncology, University Hospital, Lund, Sweden; S. Eppenberger-Castori, W. Kueng, U. Eppenberger, Stiftung Tumorbank Basel, Department of Research, University Hospital of Basel, Switzerland; C. G. J. Sweep, P. Manders, L. V. A. M. Beex, Department of Chemical Endocrinology, University Hospital Nijmegen, The Netherlands; J. P. Peyrat, Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret, Lille, France; P. M. Martin, S. Romain, Laboratoire de Transfert d'Oncologie Biologie, Marseille, France; H. Magdelenat, P. Broët, Institut Curie, Paris, France; V. Quillien, Laboratoire de Biologie, Centre Eugéne Marquis, Rennes, France; A. Daver, Centre Paul Papin, Angers, France; G. Ricolleau, Centre René Gauducheau, St. Herblain, France; W. E. Fiets, M. A. Blankenstein, University Medical Center Utrecht, The Netherlands; G. Daxenbichler, G. Windbichler, Universitätsklinik für Frauenheilkunde, Innsbruck, Austria; T. Cufer, S. Borstnar, Institut of Oncology, Ljubljana, Slovenia; N. O'Higgins, University College Dublin, Ireland.
    Dokumententyp
    • Postprint
    Sprache
    • Englisch
    Veröffentlicht in
    • Journal of the National Cancer Institute, 2002, vol. 94, no. 2, p. 116-128. Oxford University Press
    Andere elektronische Ausgabe
    Klassifikation
    • Gesundheit
    OAI-PMH-ID
    • oai:doc.rero.ch:298721
    Summary
    Background: Urokinase-type plasminogen activator (uPA) and its inhibitor (PAI-1) play essential roles in tumor invasion and metastasis. High levels of both uPA and PAI-1 are associated with poor prognosis in breast cancer patients. To confirm the prognostic value of uPA and PAI-1 in primary breast cancer, we reanalyzed individual patient data provided by members of the European Organization for Research and Treatment of Cancer-Receptor and Biomarker Group (EORTC-RBG). Methods: The study included 18 datasets involving 8377 breast cancer patients. During follow-up (median 79 months), 35% of the patients relapsed and 27% died. Levels of uPA and PAI-1 in tumor tissue extracts were determined by different immunoassays; values were ranked within each dataset and divided by the number of patients in that dataset to produce fractional ranks that could be compared directly across datasets. Associations of ranks of uPA and PAI-1 levels with relapse-free survival (RFS) and overall survival (OS) were analyzed by Cox multivariable regression analysis stratified by dataset, including the following traditional prognostic variables: age, menopausal status, lymph node status, tumor size, histologic grade, and steroid hormone-receptor status. All P values were two-sided. Results: Apart from lymph node status, high levels of uPA and PAI-1 were the strongest predictors of both poor RFS and poor OS in the analyses of all patients. Moreover, in both lymph node-positive and lymph node-negative patients, higher uPA and PAI-1 values were independently associated with poor RFS and poor OS. For (untreated) lymph node-negative patients in particular, uPA and PAI-1 included together showed strong prognostic ability (all P<.001). Conclusions: This pooled analysis of the EORTC-RBG datasets confirmed the strong and independent prognostic value of uPA and PAI-1 in primary breast cancer. For patients with lymph node-negative breast cancer, uPA and PAI-1 measurements in primary tumors may be especially useful for designing individualized treatment strategies