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The diagnosis of rupture of fetal membranes (ROM): a meta-analysis

Ramsauer, Babett ; Vidaeff, Alex C. ; Hösli, Irene ; Park, Joong Shin ; Strauss, Alexander ; Khodjaeva, Zulfiya ; de la Cruz, Ángel Aguarón ; Martínez-Astorquiza, Txantón ; Horovitz, Jacques ; Coatleven, Frederic ; Helmer, Hanns

In: Journal of Perinatal Medicine, 2013, vol. 41, no. 3, p. 233-240

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    Titre
    • The diagnosis of rupture of fetal membranes (ROM): a meta-analysis
    Auteur
    • Ramsauer, Babett. Vivantes Hospital Neukölln, Babett Ramsauer, Perinatal Medicine, Rudowerstr. 48, D-12351 Berlin, Germany
    • Vidaeff, Alex C.. Baylor College of Medicine, Houston, TX, USA
    • Hösli, Irene. University Hospital Basel, University of Basel, Basel, Switzerland
    • Park, Joong Shin. College of Medicine, Seoul National University, Seoul, Korea
    • Strauss, Alexander. University Hospital of Schleswig-Holstein, Germany
    • Khodjaeva, Zulfiya. Federal Research Center for Obstetrics and Gynecology and Perinatology, Moscow, Russia
    • de la Cruz, Ángel Aguarón. Hospital General Universitario Gregorio Marañón, Complutense University of Madrid, Madrid, Spain
    • Martínez-Astorquiza, Txantón. Cruces University Hospital, University of the Basque Country, Bilbao, Spain
    • Horovitz, Jacques. University of Bordeaux, Bordeaux, France
    • Coatleven, Frederic. University of Bordeaux, Bordeaux, France
    • Helmer, Hanns. Medical University of Vienna, Vienna, Austria
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Journal of Perinatal Medicine, 2013, vol. 41, no. 3, p. 233-240. De Gruyter
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:297698
    Summary
    Aim: The aim of this study was to compare the performance of tests based on the detection of insulin-like growth factor binding protein 1 (IGFBP-1) and placental α-microglobulin-1 (PAMG-1) in diagnosing rupture of fetal membranes (ROM) across different patient populations. Methods: A meta-analysis was conducted on prospective observational or cohort studies investigating ROM tests based on the detection of IGFBP-1 and PAMG-1 meeting the following criteria: (1) performance metrics calculated by comparing results to an adequate reference method; (2) sensitivity thresholds of the investigated tests matching those of the currently available tests; (3) study population, as a minimum, included patients between 25 and 37 weeks of gestation. Sensitivities, specificities, and diagnostic odds ratios were calculated. Results: Across all patient populations, the analyzed performance measures of the PAMG-1 test were significantly superior compared with those of the IGFBP-1 test. Of particular clinical relevance, PAMG-1 outperformed IGFBP-1 in the equivocal group, which comprised patients with uncertain rupture of membranes (sensitivity, 96.0% vs. 73.9%; specificity, 98.9% vs. 77.8%; PAMG-1 vs. IGFBP-1 tests, respectively). Conclusions: Compared with its performance in women with known membrane status, the accuracy of the IGFBP-1 test decreases significantly when used on patients whose membrane status is unknown. In this latter clinically relevant population, the PAMG-1 test has higher accuracy than the IGFBP-1 test