Fulltext

Association between the Rate of CD4+ T Cell Decrease and the Year of Human Immunodeficiency Virus (HIV) Type 1 Seroconversion among Persons Enrolled in the Swiss HIV Cohort Study

Vanhems, Philippe ; Lambert, Jean ; Guerra, Marta ; Hirschel, Bernard ; Allard, Robert

In: Journal of Infectious Diseases, 1999, vol. 180, no. 6, p. 1803-1808

Ajouter à la liste personnelle
    Titre
    • Association between the Rate of CD4+ T Cell Decrease and the Year of Human Immunodeficiency Virus (HIV) Type 1 Seroconversion among Persons Enrolled in the Swiss HIV Cohort Study
    Auteur
    • Vanhems, Philippe. Laboratoire d' Epidémiologie et de Santé Publique, INSERM Unité 271, Université Claude Bernard, Lyon, France, for the Coordinating Center of the Swiss HIV Cohort Study, CHUV, Lausanne
    • Lambert, Jean. Department of Social and Preventive Medicine, University of Montreal, Montreal, Canada
    • Guerra, Marta. Department of Social and Preventive Medicine, University of Montreal, Montreal, Canada
    • Hirschel, Bernard. Division of Infectious Diseases, University Hospital, Geneva, Switzerland
    • Allard, Robert. Department of Social and Preventive Medicine, University of Montreal, Montreal, Canada
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Journal of Infectious Diseases, 1999, vol. 180, no. 6, p. 1803-1808. The University of Chicago Press
    Autre version électronique
    Classification
    • Santé
    Identifiant OAI-PMH
    • oai:doc.rero.ch:297450
    Summary
    The aim of this study was to investigate the early CD4+ T cell response among human immunodeficiency virus type 1 (HIV-1) seroconverters in relation to their year of seroconversion. Study participants were enrolled in the Swiss HIV Cohort Study between 1985 and 1995 and had not received antiretroviral treatment. The slope of the CD4+ T cell count within 2 years after seroconversion was significantly associated with the year of seroconversion, by sex and by use of injection drugs, when controlling for initial CD4+ cell count. These results show that the loss of CD4+ cells might be associated with the year of seroconversion, suggesting a change in the pathogenesis of HIV across the years. If these results are confirmed, they could have important implications for the pathogenesis of and therapeutic strategies for HIV-1 infection