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Spirulina is an effective dietary source of zeaxanthin to humans

Yu, Bolan ; Wang, Jie ; Suter, Paolo M. ; Russell, Robert M. ; Grusak, Michael A. ; Wang, Yin ; Wang, Zhixu ; Yin, Shian ; Tang, Guangwen

In: British Journal of Nutrition, 2012, vol. 108, no. 4, p. 611-619

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    Titre
    • Spirulina is an effective dietary source of zeaxanthin to humans
    Auteur
    • Yu, Bolan. Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China
    • Wang, Jie. National Institute for Nutrition and Food Safety, Beijing, People's Republic of China
    • Suter, Paolo M.. University Hospital, Zurich and Nestlé Foundation, Lausanne, Switzerland
    • Russell, Robert M.. Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA, USA
    • Grusak, Michael A.. US Department of Agriculture/Agricultural Research Service, Children's Nutrition Research Center, Baylor College of Medicine, Houston, TX, USA
    • Wang, Yin. Zhejiang Academy of Medical Sciences, Hangzhou, People's Republic of China
    • Wang, Zhixu. Nanjing Medical University, Nanjing, People's Republic of China
    • Yin, Shian. National Institute for Nutrition and Food Safety, Beijing, People's Republic of China
    • Tang, Guangwen. Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA, USA
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • British Journal of Nutrition, 2012, vol. 108, no. 4, p. 611-619. Cambridge University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:296779
    Summary
    Zeaxanthin is a predominant xanthophyll in human eyes and may reduce the risk of cataracts and age-related macular degeneration. Spirulina is an algal food that contains a high concentration of zeaxanthin. In order to determine the zeaxanthin bioavailability of spirulina for dietary supplementation in humans, spirulina was grown in nutrient solution with 2H2O for carotenoid labelling. Single servings of 2H-labelled spirulina (4·0-5·0g) containing 2·6-3·7mg zeaxanthin were consumed by fourteen healthy male volunteers (four Americans and ten Chinese) with 12g dietary fat. Blood samples were collected over a 45d period. The serum concentrations of total zeaxanthin were measured using HPLC, and the enrichment of labelled zeaxanthin was determined using LC-atmospheric pressure chemical ionisation-MS (LC-APCI-MS). The results showed that intrinsically labelled spirulina zeaxanthin in the circulation was detected at levels as low as 10% of the total zeaxanthin for up to 45d after intake of the algae. A single dose of spirulina can increase mean serum zeaxanthin concentration in humans from 0·06 to 0·15μmol/l, as shown in our study involving American and Chinese volunteers. The average 15 d area under the serum zeaxanthin response curve to the single dose of spirulina was 293nmol×d/μmol (range 254-335) in American subjects, and 197nmol×d/μmol (range 154-285) in Chinese subjects. It is concluded that the relative bioavailability of spirulina zeaxanthin can be studied with high sensitivity and specificity using 2H labelling and LC-APCI-MS methodology. Spirulina can serve as a rich source of dietary zeaxanthin in humans