Tract-based spatial statistics to assess the neuroprotective effect of early erythropoietin on white matter development in preterm infants
O'Gorman, Ruth L. ; Bucher, Hans U. ; Held, Ulrike ; Koller, Brigitte M. ; Hüppi, Petra S. ; Hagmann, Cornelia F.
In: Brain, 2015, vol. 138, no. 2, p. 388-397
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- In a randomized double-blind placebo-controlled trial, O'Gorman et al. show that administration of erythropoietin within the first 42 hours after preterm birth improves white matter development in preterm infants. Improvements are seen in the corpus callosum, the anterior and posterior limbs of the internal capsule, and the corticospinal tract bilaterally