Alzheimer's disease cerebrospinal fluid biomarker in cognitively normal subjects
Toledo, Jon B. ; Zetterberg, Henrik ; van Harten, Argonde C. ; Glodzik, Lidia ; Martinez-Lage, Pablo ; Bocchio-Chiavetto, Luisella ; Rami, Lorena ; Hansson, Oskar ; Sperling, Reisa ; Engelborghs, Sebastiaan ; Osorio, Ricardo S. ; Vanderstichele, Hugo ; Vandijck, Manu ; Hampel, Harald ; Teipl, Stefan ; Moghekar, Abhay ; Albert, Marilyn ; Hu, William T. ; Monge Argilés, Jose A. ; Gorostidi, Ana ; Teunissen, Charlotte E. ; De Deyn, Peter P. ; Hyman, Bradley T. ; Molinuevo, Jose L. ; Frisoni, Giovanni B. ; Linazasoro, Gurutz ; de Leon, Mony J. ; van der Flier, Wiesje M. ; Scheltens, Philip ; Blennow, Kaj ; Shaw, Leslie M. ; Trojanowski, John Q.
In: Brain, 2015, vol. 138, no. 9, p. 2701-2715
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- In a large multicentre study, Toledo et al. examine core Alzheimer's disease CSF biomarkers in 1233 cognitively normal subjects aged 40-85 years. Alzheimer disease-like changes in Aβ1-42 are seen as early as middle age, while APOE genotype strongly modifies age-related effects on both Aβ1-42 and phosphorylated/total tau