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Alzheimer's disease cerebrospinal fluid biomarker in cognitively normal subjects

Toledo, Jon B. ; Zetterberg, Henrik ; van Harten, Argonde C. ; Glodzik, Lidia ; Martinez-Lage, Pablo ; Bocchio-Chiavetto, Luisella ; Rami, Lorena ; Hansson, Oskar ; Sperling, Reisa ; Engelborghs, Sebastiaan ; Osorio, Ricardo S. ; Vanderstichele, Hugo ; Vandijck, Manu ; Hampel, Harald ; Teipl, Stefan ; Moghekar, Abhay ; Albert, Marilyn ; Hu, William T. ; Monge Argilés, Jose A. ; Gorostidi, Ana ; Teunissen, Charlotte E. ; De Deyn, Peter P. ; Hyman, Bradley T. ; Molinuevo, Jose L. ; Frisoni, Giovanni B. ; Linazasoro, Gurutz ; de Leon, Mony J. ; van der Flier, Wiesje M. ; Scheltens, Philip ; Blennow, Kaj ; Shaw, Leslie M. ; Trojanowski, John Q.

In: Brain, 2015, vol. 138, no. 9, p. 2701-2715

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    Titel
    • Alzheimer's disease cerebrospinal fluid biomarker in cognitively normal subjects
    Autor
    • Toledo, Jon B.. 1 Department of Pathology and Laboratory Medicine, Institute on Aging, Centre for Neurodegenerative Disease Research, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
    • Zetterberg, Henrik. 2 Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    • van Harten, Argonde C.. 4 Alzheimer Centre and Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Centre, Amsterdam, The Netherlands
    • Glodzik, Lidia. 5 Centre for Brain Health, Department of Psychiatry, New York University School of Medicine, New York, USA
    • Martinez-Lage, Pablo. 6 Department of Neurology, Centre for Research and Advanced Therapies. Fundación CITA-Alzheimer Fundazioa, Donostia/San Sebastián, Spain
    • Bocchio-Chiavetto, Luisella. 7 IRCCS Centro San Giovanni di Dio FBF, Brescia, Italy
    • Rami, Lorena. 9 Alzheimer's Disease and Other Cognitive Disorders Unit, Hospital Clinic i Universitari, Barcelona, Spain
    • Hansson, Oskar. 10 Department of Clinical Sciences, Lund University, Lund, Sweden
    • Sperling, Reisa. 11 Memory clinic, Skåne University Hospital, Lund, Sweden
    • Engelborghs, Sebastiaan. 13 Department of Neurology and Memory Clinic, Hospital Network Antwerp, Middelheim and Hoge Beuken, Belgium
    • Osorio, Ricardo S.. 5 Centre for Brain Health, Department of Psychiatry, New York University School of Medicine, New York, USA
    • Vanderstichele, Hugo. 15 ADx NeuroSciences, Technologiepark 4, Gent, Belgium
    • Vandijck, Manu. 16 Fujirebio Europe nv, Technologiepark 6, Gent, Belgium
    • Hampel, Harald. 17 AXA Research Fund and UPMC, Université Pierre et Marie Curie, Paris, France
    • Teipl, Stefan. 19 Department of Psychosomatic Medicine, University Medicine Rostock, Rostock, Germany
    • Moghekar, Abhay. 21 Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    • Albert, Marilyn. 21 Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    • Hu, William T.. 22 Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA
    • Monge Argilés, Jose A.. 23 Department of Neurology, University General Hospital of Alicante, Alicante, Spain
    • Gorostidi, Ana. 24 Neuroscience Unit, Biodonostia Research Institute, San Sebastian, Spain
    • Teunissen, Charlotte E.. 25 Neurochemistry Lab and Biobank, Dept. of Clinical Chemistry, Neuroscience Campus Amsterdam, VU University Medical Centre Amsterdam, The Netherlands
    • De Deyn, Peter P.. 13 Department of Neurology and Memory Clinic, Hospital Network Antwerp, Middelheim and Hoge Beuken, Belgium
    • Hyman, Bradley T.. 12 Massachusetts Alzheimer's Disease Research Centre, Harvard Aging Brain Study, Department of Neurology; Massachusetts General Hospital, Harvard Medical School, Boston, MA,USA
    • Molinuevo, Jose L.. 9 Alzheimer's Disease and Other Cognitive Disorders Unit, Hospital Clinic i Universitari, Barcelona, Spain
    • Frisoni, Giovanni B.. 7 IRCCS Centro San Giovanni di Dio FBF, Brescia, Italy
    • Linazasoro, Gurutz. 6 Department of Neurology, Centre for Research and Advanced Therapies. Fundación CITA-Alzheimer Fundazioa, Donostia/San Sebastián, Spain
    • de Leon, Mony J.. 5 Centre for Brain Health, Department of Psychiatry, New York University School of Medicine, New York, USA
    • van der Flier, Wiesje M.. 4 Alzheimer Centre and Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Centre, Amsterdam, The Netherlands
    • Scheltens, Philip. 4 Alzheimer Centre and Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Centre, Amsterdam, The Netherlands
    • Blennow, Kaj. 2 Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    • Shaw, Leslie M.. 1 Department of Pathology and Laboratory Medicine, Institute on Aging, Centre for Neurodegenerative Disease Research, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
    • Trojanowski, John Q.. 1 Department of Pathology and Laboratory Medicine, Institute on Aging, Centre for Neurodegenerative Disease Research, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
    Dokumententyp
    • Postprint
    Sprache
    • Englisch
    Veröffentlicht in
    • Brain, 2015, vol. 138, no. 9, p. 2701-2715. Oxford University Press
    Andere elektronische Ausgabe
    OAI-PMH-ID
    • oai:doc.rero.ch:296456
    Summary
    In a large multicentre study, Toledo et al. examine core Alzheimer's disease CSF biomarkers in 1233 cognitively normal subjects aged 40-85 years. Alzheimer disease-like changes in Aβ1-42 are seen as early as middle age, while APOE genotype strongly modifies age-related effects on both Aβ1-42 and phosphorylated/total tau