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Down Selection of Polymerized Bovine Hemoglobins for Use as Oxygen Releasing Therapeutics in a Guinea Pig Model

Baek, Jin Hyen ; Zhou, Yipin ; Harris, David R. ; Schaer, Dominik J. ; Palmer, Andre F. ; Buehler, Paul W.

In: Toxicological Sciences, 2012, vol. 127, no. 2, p. 567-581

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    Titre
    • Down Selection of Polymerized Bovine Hemoglobins for Use as Oxygen Releasing Therapeutics in a Guinea Pig Model
    Auteur
    • Baek, Jin Hyen. Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Bethesda, Maryland 20892
    • Zhou, Yipin. William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio 43210
    • Harris, David R.. William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio 43210
    • Schaer, Dominik J.. Division of Internal Medicine, University Hospital, CH-8091 Zurich, Switzerland
    • Palmer, Andre F.. William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio 43210
    • Buehler, Paul W.. Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Bethesda, Maryland 20892
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Toxicological Sciences, 2012, vol. 127, no. 2, p. 567-581. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:296290
    Summary
    Editor's Highlight: The development of hemoglobin-based oxygen carriers (HBOCs) as a replacement for whole-blood transfusions has been impeded by their systemic toxicity. This paper presents data from a series of HBOCs, demonstrating one candidate that meets predetermined safety criteria. This approach may allow the development of an acceptable blood substitute for human use