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Genetic manipulation of adult-born hippocampal neurons rescues memory in a mouse model of Alzheimer's disease

Richetin, Kevin ; Leclerc, Clémence ; Toni, Nicolas ; Gallopin, Thierry ; Pech, Stéphane ; Roybon, Laurent ; Rampon, Claire

In: Brain, 2015, vol. 138, no. 2, p. 440-455

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    Titre
    • Genetic manipulation of adult-born hippocampal neurons rescues memory in a mouse model of Alzheimer's disease
    Auteur
    • Richetin, Kevin. 1 Université de Toulouse, UPS, Centre de Recherches sur la Cognition Animale, 118 route de Narbonne, F-31062 Toulouse Cedex 4, France
    • Leclerc, Clémence. 1 Université de Toulouse, UPS, Centre de Recherches sur la Cognition Animale, 118 route de Narbonne, F-31062 Toulouse Cedex 4, France
    • Toni, Nicolas. 4 Department of Fundamental Neurosciences, University of Lausanne, Rue du Bugnon 9, CH-1005 Lausanne, Switzerland
    • Gallopin, Thierry. 3 Laboratoire de Neurobiologie, ESPCI ParisTech, UMR 7637, Paris, France
    • Pech, Stéphane. 1 Université de Toulouse, UPS, Centre de Recherches sur la Cognition Animale, 118 route de Narbonne, F-31062 Toulouse Cedex 4, France
    • Roybon, Laurent. 5 Stem Cell Laboratory for CNS Disease Modeling, Department of Experimental Medical Science, Wallenberg Neuroscience Centre, Lund University, BMC A10, 221 84 Lund, Sweden
    • Rampon, Claire. 1 Université de Toulouse, UPS, Centre de Recherches sur la Cognition Animale, 118 route de Narbonne, F-31062 Toulouse Cedex 4, France
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Brain, 2015, vol. 138, no. 2, p. 440-455. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:295911
    Summary
    Richetin et al. demonstrate that retroviral expression of the transcription factor NeuroD1 in neural progenitor cells of the adult mouse hippocampus promotes differentiation, maturation and synaptic integration of newborn granule cells in vivo. When applied to a mouse model of Alzheimer's disease, the gene-targeting strategy abolishes hippocampus-dependent memory deficits