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Low Levels of Perforin Expression in CD8+ T Lymphocyte Granules in Lymphoid Tissue during Acute Human Immunodeficiency Virus Type 1 Infection

Andersson, Jan ; Kinloch, Sabine ; Sönnerborg, Anders ; Nilsson, Jakob ; Fehniger, Thomas E. ; Spetz, Anna-Lena ; Behbahani, Homira ; Goh, Li-Ean ; McDade, Hugh ; Gazzard, Brian ; Stellbrink, Hans ; Cooper, David ; Perrin, Luc

In: The Journal of Infectious Diseases, 2002, vol. 185, no. 9, p. 1355-1358

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    Titel
    • Low Levels of Perforin Expression in CD8+ T Lymphocyte Granules in Lymphoid Tissue during Acute Human Immunodeficiency Virus Type 1 Infection
    Autor
    • Andersson, Jan. Department of Medicine, Center for Infectious Medicine, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    • Kinloch, Sabine. Department of Clinical Immunology, Royal Free Hospital, London
    • Sönnerborg, Anders. Department of Medicine, Center for Infectious Medicine, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    • Nilsson, Jakob. Department of Medicine, Center for Infectious Medicine, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    • Fehniger, Thomas E.. Department of Medicine, Center for Infectious Medicine, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    • Spetz, Anna-Lena. Department of Medicine, Center for Infectious Medicine, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    • Behbahani, Homira. Department of Medicine, Center for Infectious Medicine, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    • Goh, Li-Ean. GlaxoWellcome Research and Development, HIV Department, Greenford, United Kingdom
    • McDade, Hugh. GlaxoWellcome Research and Development, HIV Department, Greenford, United Kingdom
    • Gazzard, Brian. Kobler Centre, St. Stephen's Clinic, Chelsea and Westminster Hospital, London
    • Stellbrink, Hans. Medizin Poliklinik, Universitatsklinikum Eppendorf, Hamburg, Germany
    • Cooper, David. National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, New South Wales, Australia
    • Perrin, Luc. Central Virology Laboratory, Department of Infectious Diseases, Geneva University Hospital, Geneva, Switzerland
    Dokumententyp
    • Postprint
    Sprache
    • Englisch
    Veröffentlicht in
    • The Journal of Infectious Diseases, 2002, vol. 185, no. 9, p. 1355-1358. The University of Chicago Press
    Andere elektronische Ausgabe
    Klassifikation
    • Gesundheit
    OAI-PMH-ID
    • oai:doc.rero.ch:295784
    Summary
    Human immunodeficiency virus (HIV)-specific cytotoxic T lymphocyte (CTL) responses are detectable shortly after the acute phase of HIV infection, but they cannot control viral replication and prevent development of chronic immune suppression. This article describes a defect in the coexpression of perforin in granzyme A-positive CD8+ T cells in lymphoid tissue from patients with acute HIV infection and a reduction in the perforin-dependent nuclear translocation of granzyme A. Furthermore, intracellular levels of HIV DNA and RNA found in lymphoid tissue were higher (10-100 times) than those found in blood, and blood samples showed more-coordinated cellular perforin/granzyme A expression. This suggests that mechanisms inhibiting CTL-mediated cytotoxicity are operative in lymphoid tissue early in the course of HIV infection