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Fibre intake and laryngeal cancer risk

Pelucchi, C. ; Talamini, R. ; Levi, F. ; Bosetti, C. ; La Vecchia, C. ; Negri, E. ; Parpinel, M. ; Franceschi, S.

In: Annals of Oncology, 2003, vol. 14, no. 1, p. 162-167

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    Titel
    • Fibre intake and laryngeal cancer risk
    Autor
    • Pelucchi, C.. Istituto di Ricerche Farmacologiche ‘Mario Negri', Milan
    • Talamini, R.. Servizio di Epidemiologia, Centro di Riferimento Oncologico, Aviano, Italy
    • Levi, F.. Registre Vaudois des Tumeurs, Institut Universitaire de Médecine Sociale et Préventive, Lausanne, Switzerland
    • Bosetti, C.. Istituto di Ricerche Farmacologiche ‘Mario Negri', Milan
    • La Vecchia, C.. Istituto di Ricerche Farmacologiche ‘Mario Negri', Milan
    • Negri, E.. Istituto di Ricerche Farmacologiche ‘Mario Negri', Milan
    • Parpinel, M.. Servizio di Epidemiologia, Centro di Riferimento Oncologico, Aviano, Italy
    • Franceschi, S.. International Agency for Research on Cancer, Lyon, France
    Dokumententyp
    • Postprint
    Sprache
    • Englisch
    Veröffentlicht in
    • Annals of Oncology, 2003, vol. 14, no. 1, p. 162-167. Oxford University Press
    Andere elektronische Ausgabe
    OAI-PMH-ID
    • oai:doc.rero.ch:295688
    Summary
    Background: Consumption of vegetables, fruit and whole grain cereals has been inversely related to laryngeal cancer risk. Among the potential protective agents found in these foods, information on dietary fibres and laryngeal cancer risk are scanty. Patients and methods: A multi-centric, hospital-based case-control study was conducted on 527 patients with squamous-cell carcinoma of the larynx and 1297 non-neoplastic controls. Cases and controls, frequency matched by age, sex and study centre, were interviewed using a validated food frequency questionnaire. Results: Compared with the lowest quintile of fibre intake, the odds ratios (ORs) for the highest quintile were 0.3 [95% confidence interval (CI) 0.2-0.4] for total fibre, 0.3 (95% CI 0.2-0.5) for soluble non-cellulose polysaccharides (NCP) and for total insoluble fibre, including cellulose (OR = 0.3, 95% CI 0.2-0.4) and insoluble NCP (OR = 0.4, 95% CI 0.3-0.7). The ORs were 0.2 (95% CI 0.1-0.4) for fibre from vegetables, 0.5 (95% CI 0.3-0.7) from fruit and 1.1 (95% CI 0.6-1.9) from grains. The inverse association observed was similar among different subsites of laryngeal cancer, and consistent across strata of various covariates. Conclusions: This study found a strong inverse association between fibre intake and laryngeal cancer risk, which points to fibre as one of the beneficial components of vegetables and fruit