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fastsimcoal: a continuous-time coalescent simulator of genomic diversity under arbitrarily complex evolutionary scenarios

Excoffier, Laurent ; Foll, Matthieu

In: Bioinformatics, 2011, vol. 27, no. 9, p. 1332-1334

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    Titre
    • fastsimcoal: a continuous-time coalescent simulator of genomic diversity under arbitrarily complex evolutionary scenarios
    Auteur
    • Excoffier, Laurent. Institute of Ecology and Evolution, University of Berne, 3012 Berne and Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland
    • Foll, Matthieu. Institute of Ecology and Evolution, University of Berne, 3012 Berne and Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland
    Type de document
    • Postprint
    Identifiant OAI-PMH
    • oai:doc.rero.ch:295478
    Summary
    Motivation: Genetic studies focus on increasingly larger genomic regions of both extant and ancient DNA, and there is a need for simulation software to match these technological advances. We present here a new coalescent-based simulation program fastsimcoal, which is able to quickly simulate a variety of genetic markers scattered over very long genomic regions with arbitrary recombination patterns under complex evolutionary scenarios. Availability and Implementation: fastsimcoal is a C++ program compiled for Windows, MacOsX and Linux platforms. It is freely available at cmpg.unibe.ch/software/fastsimcoal/, together with its detailed user manual and example input files. Contact: laurent.excoffier@iee.unibe.ch Supplementary Information: Supplementary data are available at Bioinformatics online