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Fatal anaphylactoid response to protamine after percutaneous transluminal coronary angioplasty

NEIDHART, P. P. ; MEIER, B. ; POLLA, B. S. ; SCHIFFERLI, J. A. ; MOREL, D. R.

In: European Heart Journal, 1992, vol. 13, no. 6, p. 856-858

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    Titre
    • Fatal anaphylactoid response to protamine after percutaneous transluminal coronary angioplasty
    Auteur
    • NEIDHART, P. P.. Departments of Anaesthesia and Medicine, University Hospital of Geneva Geneva, Switzerland
    • MEIER, B.. Departments of Anaesthesia and Medicine, University Hospital of Geneva Geneva, Switzerland
    • POLLA, B. S.. Departments of Anaesthesia and Medicine, University Hospital of Geneva Geneva, Switzerland
    • SCHIFFERLI, J. A.. Departments of Cardiology Center, University Hospital of Geneva Geneva, Switzerland
    • MOREL, D. R.. Departments of Anaesthesia and Medicine, University Hospital of Geneva Geneva, Switzerland
    Type de document
    • Postprint
    Identifiant OAI-PMH
    • oai:doc.rero.ch:294630
    Summary
    A generalized skin erythema and severe hypotension developed following administration of protamine for the reversal of heparin anticoagulation after an unsuccessful attempt at percutaneous transluminal angioplasty in a patient who had never been exposed to protamines before. Evidence of classical pathway complement activation was present indicating that this reaction could have been triggered by a non-immunological mechanism. The patient could not adequately be resuscitated because of the presence of severe coronary artery disease