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Drug monographs on drugs which are frequently analysed in the context of Therapeutic Drug Monitoring

Rentsch (President), Working group "Drug Monitoring” of the SSCC (Arbeitsgruppe Medikamente der SGKC): Katharina ; Baumann, Pierre ; Fathi, Marc ; Grignaschi, Nathalie ; Magnin, Jean-Luc ; Thormann, Wolfgang ; Todesco, Liliane ; Wenk, Markus ; Werner, Dominique

In: LaboratoriumsMedizin, 2006, vol. 30, no. 6, p. 443-452

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    Titre
    • Drug monographs on drugs which are frequently analysed in the context of Therapeutic Drug Monitoring
    Auteur
    • Rentsch (President), Working group "Drug Monitoring” of the SSCC (Arbeitsgruppe Medikamente der SGKC): Katharina. University Hospital Zurich, Zurich, Switzerland
    • Baumann, Pierre. University Hospital Prilly-Lausanne, Lausanne, Switzerland
    • Fathi, Marc. University Hospital Geneva, Geneva, Switzerland
    • Grignaschi, Nathalie. University Hospital Basle, Basle, Switzerland
    • Magnin, Jean-Luc. Kantonsspital Freiburg, Freiburg, Switzerland
    • Thormann, Wolfgang. University of Berne, Berne, Switzerland
    • Todesco, Liliane. University Hospital Basle, Basle, Switzerland
    • Wenk, Markus. University Hospital Basle, Basle, Switzerland
    • Werner, Dominique. University Hospital Lausanne, Lausanne, Switzerland
    Type de document
    • Postprint
    Langue
    • Multilingue
    Publié dans
    • LaboratoriumsMedizin, 2006, vol. 30, no. 6, p. 443-452. Walter de Gruyter
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:294273
    Summary
    In addition to the monographs which were published last year by the working group "Drug Monitoring” of the Swiss Society of Clinical Chemistry (SSCC) [1], new monographs have been written. The aim of these monographs is to give an overview of the most important information necessary for ordering a drug analysis or interpreting the results. Therefore, the targeted readers comprise laboratory health professionals and all receivers of laboratory reports. There is information provided on the indication for therapeutic drug monitoring, protein binding, metabolic pathways and enzymes involved, elimination half-life and elimination routes, and on therapeutic or toxic concentrations. Preanalytical considerations are of particular importance for therapeutic drug monitoring. Therefore, information is provided regarding a reasonable timing for the determination of drug concentrations as well as steady-state concentrations after changing the dose. Furthermore, the stability of the drug and its metabolite(s) after blood sampling is described. For readers with a specific interest in drug analysis, references to important publications are given. The number of monographs will be continuously enlarged. The updated files are presented on the homepage of the SSCC (www.sscc.ch). We hope that these monographs are helpful and look forward to receiving comments from the audience