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S.11.1 Influence of digital ulcer healing on disability and daily activity limitations in SSc

Bérezné, A. ; Seror, R. ; Bussone, G. ; Nguyen, C. ; Morell-Dubois, S. ; Fois, E. ; Guillevin, L. ; Mouthon, L. ; Mouthon, L. ; Carpentier, P. ; Khau Van Kien, A. ; Clerson, P. ; Maillard, H. ; Hachulla, E. ; Frances, C. ; Diot, E. ; Lok, C. ; Puzenat, E. ; Sparsa, A. ; Bérezné, A. ; Gressin, V. ; Richard, M. A. ; Saketkoo, L. A. ; Escorpizo, R. ; Keen, K. ; Fligelstone, K. ; Distler, O. ; Assassi, S. ; Leyva, A. ; Mayes, M. ; Sharif, R. ; Nair, D. ; Fischbach, M. ; Nguyen, N. ; Reveille, J. ; Gonzalez, E. ; McNearney, T. ; Riccieri, V. ; Sciarra, I. ; Maset, L. ; Passi, L. ; Stefanantoni, K. ; Vasile, M. ; Scarno, A. ; Spadaro, A.

In: Rheumatology, 2012, vol. 51, p. ii20-ii23

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    Titre
    • S.11.1 Influence of digital ulcer healing on disability and daily activity limitations in SSc
    Auteur
    • Bérezné, A.. Université Paris Descartes, Médecine Interne, Centre de Référence Sclérodermie, Hôpital Cochin, Paris, Université Paris Sud, pôle de Rhumatologie, INSERM U802, Hôpital Bicêtre, Le Kremlin Bicêtre, Université Paris Descartes, Service de Médecine Physique et Réadaptation, Hôpital Cochin, Paris, Université Lille 2, Médecine Interne, Centre de Référence Sclérodermie, Hôpital Claude Huriez, Lille and Inserm U1016, Institut Cochin, Paris, France.
    • Seror, R.. Université Paris Descartes, Médecine Interne, Centre de Référence Sclérodermie, Hôpital Cochin, Paris, Université Paris Sud, pôle de Rhumatologie, INSERM U802, Hôpital Bicêtre, Le Kremlin Bicêtre, Université Paris Descartes, Service de Médecine Physique et Réadaptation, Hôpital Cochin, Paris, Université Lille 2, Médecine Interne, Centre de Référence Sclérodermie, Hôpital Claude Huriez, Lille and Inserm U1016, Institut Cochin, Paris, France.
    • Bussone, G.. Université Paris Descartes, Médecine Interne, Centre de Référence Sclérodermie, Hôpital Cochin, Paris, Université Paris Sud, pôle de Rhumatologie, INSERM U802, Hôpital Bicêtre, Le Kremlin Bicêtre, Université Paris Descartes, Service de Médecine Physique et Réadaptation, Hôpital Cochin, Paris, Université Lille 2, Médecine Interne, Centre de Référence Sclérodermie, Hôpital Claude Huriez, Lille and Inserm U1016, Institut Cochin, Paris, France.
    • Nguyen, C.. Université Paris Descartes, Médecine Interne, Centre de Référence Sclérodermie, Hôpital Cochin, Paris, Université Paris Sud, pôle de Rhumatologie, INSERM U802, Hôpital Bicêtre, Le Kremlin Bicêtre, Université Paris Descartes, Service de Médecine Physique et Réadaptation, Hôpital Cochin, Paris, Université Lille 2, Médecine Interne, Centre de Référence Sclérodermie, Hôpital Claude Huriez, Lille and Inserm U1016, Institut Cochin, Paris, France.
    • Morell-Dubois, S.. Université Paris Descartes, Médecine Interne, Centre de Référence Sclérodermie, Hôpital Cochin, Paris, Université Paris Sud, pôle de Rhumatologie, INSERM U802, Hôpital Bicêtre, Le Kremlin Bicêtre, Université Paris Descartes, Service de Médecine Physique et Réadaptation, Hôpital Cochin, Paris, Université Lille 2, Médecine Interne, Centre de Référence Sclérodermie, Hôpital Claude Huriez, Lille and Inserm U1016, Institut Cochin, Paris, France.
    • Fois, E.. Université Paris Descartes, Médecine Interne, Centre de Référence Sclérodermie, Hôpital Cochin, Paris, Université Paris Sud, pôle de Rhumatologie, INSERM U802, Hôpital Bicêtre, Le Kremlin Bicêtre, Université Paris Descartes, Service de Médecine Physique et Réadaptation, Hôpital Cochin, Paris, Université Lille 2, Médecine Interne, Centre de Référence Sclérodermie, Hôpital Claude Huriez, Lille and Inserm U1016, Institut Cochin, Paris, France.
    • Guillevin, L.. Université Paris Descartes, Médecine Interne, Centre de Référence Sclérodermie, Hôpital Cochin, Paris, Université Paris Sud, pôle de Rhumatologie, INSERM U802, Hôpital Bicêtre, Le Kremlin Bicêtre, Université Paris Descartes, Service de Médecine Physique et Réadaptation, Hôpital Cochin, Paris, Université Lille 2, Médecine Interne, Centre de Référence Sclérodermie, Hôpital Claude Huriez, Lille and Inserm U1016, Institut Cochin, Paris, France.
    • Mouthon, L.. Université Paris Descartes, Médecine Interne, Centre de Référence Sclérodermie, Hôpital Cochin, Paris, Université Paris Sud, pôle de Rhumatologie, INSERM U802, Hôpital Bicêtre, Le Kremlin Bicêtre, Université Paris Descartes, Service de Médecine Physique et Réadaptation, Hôpital Cochin, Paris, Université Lille 2, Médecine Interne, Centre de Référence Sclérodermie, Hôpital Claude Huriez, Lille and Inserm U1016, Institut Cochin, Paris, France.
    • Mouthon, L.. Internal Medicine Department, Cochin Hospital, Paris Descartes University, Paris, Vascular Medicine, CHU Grenoble, Grenoble, Vascular Medicine, CHU Montpellier, Montpellier, Orgamétrie, Roubaix, Dermatology, CH Le Mans, Le Mans, Internal Medicine, CHRU Lille, Lille, Dermatology, Tenon Hospital, Paris, Internal Medicine, CHU Tours, Tours, Dermatology, CHU Amiens, Amiens, Dermatology, CHU Besançon, Besançon, France, Dermathology, CHU Limoges, Actecion, and Dermathology, Hopital Sainte Marguerite, Marseille, France
    • Carpentier, P.. Internal Medicine Department, Cochin Hospital, Paris Descartes University, Paris, Vascular Medicine, CHU Grenoble, Grenoble, Vascular Medicine, CHU Montpellier, Montpellier, Orgamétrie, Roubaix, Dermatology, CH Le Mans, Le Mans, Internal Medicine, CHRU Lille, Lille, Dermatology, Tenon Hospital, Paris, Internal Medicine, CHU Tours, Tours, Dermatology, CHU Amiens, Amiens, Dermatology, CHU Besançon, Besançon, France, Dermathology, CHU Limoges, Actecion, and Dermathology, Hopital Sainte Marguerite, Marseille, France
    • Khau Van Kien, A.. Internal Medicine Department, Cochin Hospital, Paris Descartes University, Paris, Vascular Medicine, CHU Grenoble, Grenoble, Vascular Medicine, CHU Montpellier, Montpellier, Orgamétrie, Roubaix, Dermatology, CH Le Mans, Le Mans, Internal Medicine, CHRU Lille, Lille, Dermatology, Tenon Hospital, Paris, Internal Medicine, CHU Tours, Tours, Dermatology, CHU Amiens, Amiens, Dermatology, CHU Besançon, Besançon, France, Dermathology, CHU Limoges, Actecion, and Dermathology, Hopital Sainte Marguerite, Marseille, France
    • Clerson, P.. Internal Medicine Department, Cochin Hospital, Paris Descartes University, Paris, Vascular Medicine, CHU Grenoble, Grenoble, Vascular Medicine, CHU Montpellier, Montpellier, Orgamétrie, Roubaix, Dermatology, CH Le Mans, Le Mans, Internal Medicine, CHRU Lille, Lille, Dermatology, Tenon Hospital, Paris, Internal Medicine, CHU Tours, Tours, Dermatology, CHU Amiens, Amiens, Dermatology, CHU Besançon, Besançon, France, Dermathology, CHU Limoges, Actecion, and Dermathology, Hopital Sainte Marguerite, Marseille, France
    • Maillard, H.. Internal Medicine Department, Cochin Hospital, Paris Descartes University, Paris, Vascular Medicine, CHU Grenoble, Grenoble, Vascular Medicine, CHU Montpellier, Montpellier, Orgamétrie, Roubaix, Dermatology, CH Le Mans, Le Mans, Internal Medicine, CHRU Lille, Lille, Dermatology, Tenon Hospital, Paris, Internal Medicine, CHU Tours, Tours, Dermatology, CHU Amiens, Amiens, Dermatology, CHU Besançon, Besançon, France, Dermathology, CHU Limoges, Actecion, and Dermathology, Hopital Sainte Marguerite, Marseille, France
    • Hachulla, E.. Internal Medicine Department, Cochin Hospital, Paris Descartes University, Paris, Vascular Medicine, CHU Grenoble, Grenoble, Vascular Medicine, CHU Montpellier, Montpellier, Orgamétrie, Roubaix, Dermatology, CH Le Mans, Le Mans, Internal Medicine, CHRU Lille, Lille, Dermatology, Tenon Hospital, Paris, Internal Medicine, CHU Tours, Tours, Dermatology, CHU Amiens, Amiens, Dermatology, CHU Besançon, Besançon, France, Dermathology, CHU Limoges, Actecion, and Dermathology, Hopital Sainte Marguerite, Marseille, France
    • Frances, C.. Internal Medicine Department, Cochin Hospital, Paris Descartes University, Paris, Vascular Medicine, CHU Grenoble, Grenoble, Vascular Medicine, CHU Montpellier, Montpellier, Orgamétrie, Roubaix, Dermatology, CH Le Mans, Le Mans, Internal Medicine, CHRU Lille, Lille, Dermatology, Tenon Hospital, Paris, Internal Medicine, CHU Tours, Tours, Dermatology, CHU Amiens, Amiens, Dermatology, CHU Besançon, Besançon, France, Dermathology, CHU Limoges, Actecion, and Dermathology, Hopital Sainte Marguerite, Marseille, France
    • Diot, E.. Internal Medicine Department, Cochin Hospital, Paris Descartes University, Paris, Vascular Medicine, CHU Grenoble, Grenoble, Vascular Medicine, CHU Montpellier, Montpellier, Orgamétrie, Roubaix, Dermatology, CH Le Mans, Le Mans, Internal Medicine, CHRU Lille, Lille, Dermatology, Tenon Hospital, Paris, Internal Medicine, CHU Tours, Tours, Dermatology, CHU Amiens, Amiens, Dermatology, CHU Besançon, Besançon, France, Dermathology, CHU Limoges, Actecion, and Dermathology, Hopital Sainte Marguerite, Marseille, France
    • Lok, C.. Internal Medicine Department, Cochin Hospital, Paris Descartes University, Paris, Vascular Medicine, CHU Grenoble, Grenoble, Vascular Medicine, CHU Montpellier, Montpellier, Orgamétrie, Roubaix, Dermatology, CH Le Mans, Le Mans, Internal Medicine, CHRU Lille, Lille, Dermatology, Tenon Hospital, Paris, Internal Medicine, CHU Tours, Tours, Dermatology, CHU Amiens, Amiens, Dermatology, CHU Besançon, Besançon, France, Dermathology, CHU Limoges, Actecion, and Dermathology, Hopital Sainte Marguerite, Marseille, France
    • Puzenat, E.. Internal Medicine Department, Cochin Hospital, Paris Descartes University, Paris, Vascular Medicine, CHU Grenoble, Grenoble, Vascular Medicine, CHU Montpellier, Montpellier, Orgamétrie, Roubaix, Dermatology, CH Le Mans, Le Mans, Internal Medicine, CHRU Lille, Lille, Dermatology, Tenon Hospital, Paris, Internal Medicine, CHU Tours, Tours, Dermatology, CHU Amiens, Amiens, Dermatology, CHU Besançon, Besançon, France, Dermathology, CHU Limoges, Actecion, and Dermathology, Hopital Sainte Marguerite, Marseille, France
    • Sparsa, A.. Internal Medicine Department, Cochin Hospital, Paris Descartes University, Paris, Vascular Medicine, CHU Grenoble, Grenoble, Vascular Medicine, CHU Montpellier, Montpellier, Orgamétrie, Roubaix, Dermatology, CH Le Mans, Le Mans, Internal Medicine, CHRU Lille, Lille, Dermatology, Tenon Hospital, Paris, Internal Medicine, CHU Tours, Tours, Dermatology, CHU Amiens, Amiens, Dermatology, CHU Besançon, Besançon, France, Dermathology, CHU Limoges, Actecion, and Dermathology, Hopital Sainte Marguerite, Marseille, France
    • Bérezné, A.. Internal Medicine Department, Cochin Hospital, Paris Descartes University, Paris, Vascular Medicine, CHU Grenoble, Grenoble, Vascular Medicine, CHU Montpellier, Montpellier, Orgamétrie, Roubaix, Dermatology, CH Le Mans, Le Mans, Internal Medicine, CHRU Lille, Lille, Dermatology, Tenon Hospital, Paris, Internal Medicine, CHU Tours, Tours, Dermatology, CHU Amiens, Amiens, Dermatology, CHU Besançon, Besançon, France, Dermathology, CHU Limoges, Actecion, and Dermathology, Hopital Sainte Marguerite, Marseille, France
    • Gressin, V.. Internal Medicine Department, Cochin Hospital, Paris Descartes University, Paris, Vascular Medicine, CHU Grenoble, Grenoble, Vascular Medicine, CHU Montpellier, Montpellier, Orgamétrie, Roubaix, Dermatology, CH Le Mans, Le Mans, Internal Medicine, CHRU Lille, Lille, Dermatology, Tenon Hospital, Paris, Internal Medicine, CHU Tours, Tours, Dermatology, CHU Amiens, Amiens, Dermatology, CHU Besançon, Besançon, France, Dermathology, CHU Limoges, Actecion, and Dermathology, Hopital Sainte Marguerite, Marseille, France
    • Richard, M. A.. Internal Medicine Department, Cochin Hospital, Paris Descartes University, Paris, Vascular Medicine, CHU Grenoble, Grenoble, Vascular Medicine, CHU Montpellier, Montpellier, Orgamétrie, Roubaix, Dermatology, CH Le Mans, Le Mans, Internal Medicine, CHRU Lille, Lille, Dermatology, Tenon Hospital, Paris, Internal Medicine, CHU Tours, Tours, Dermatology, CHU Amiens, Amiens, Dermatology, CHU Besançon, Besançon, France, Dermathology, CHU Limoges, Actecion, and Dermathology, Hopital Sainte Marguerite, Marseille, France
    • Saketkoo, L. A.. Louisiana State University Scleroderma and Sarcoidosis Patient Care and Research Center, New Orleans, USA, ICF Research Branch in cooperation with the WHO Collaborating Centre for the Family of International Classifications, Nottwil, Department of Health Sciences and Health Policy, University of Lucerne, Lucerne, Switzerland, Department of Mathematics and Statistics, University of Northern British Columbia, Prince George, Canada, Royal Free Hospital, Scleroderma Unit, London, Scleroderma Society, Chichester, UK and Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland.
    • Escorpizo, R.. Louisiana State University Scleroderma and Sarcoidosis Patient Care and Research Center, New Orleans, USA, ICF Research Branch in cooperation with the WHO Collaborating Centre for the Family of International Classifications, Nottwil, Department of Health Sciences and Health Policy, University of Lucerne, Lucerne, Switzerland, Department of Mathematics and Statistics, University of Northern British Columbia, Prince George, Canada, Royal Free Hospital, Scleroderma Unit, London, Scleroderma Society, Chichester, UK and Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland.
    • Keen, K.. Louisiana State University Scleroderma and Sarcoidosis Patient Care and Research Center, New Orleans, USA, ICF Research Branch in cooperation with the WHO Collaborating Centre for the Family of International Classifications, Nottwil, Department of Health Sciences and Health Policy, University of Lucerne, Lucerne, Switzerland, Department of Mathematics and Statistics, University of Northern British Columbia, Prince George, Canada, Royal Free Hospital, Scleroderma Unit, London, Scleroderma Society, Chichester, UK and Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland.
    • Fligelstone, K.. Louisiana State University Scleroderma and Sarcoidosis Patient Care and Research Center, New Orleans, USA, ICF Research Branch in cooperation with the WHO Collaborating Centre for the Family of International Classifications, Nottwil, Department of Health Sciences and Health Policy, University of Lucerne, Lucerne, Switzerland, Department of Mathematics and Statistics, University of Northern British Columbia, Prince George, Canada, Royal Free Hospital, Scleroderma Unit, London, Scleroderma Society, Chichester, UK and Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland.
    • Distler, O.. Louisiana State University Scleroderma and Sarcoidosis Patient Care and Research Center, New Orleans, USA, ICF Research Branch in cooperation with the WHO Collaborating Centre for the Family of International Classifications, Nottwil, Department of Health Sciences and Health Policy, University of Lucerne, Lucerne, Switzerland, Department of Mathematics and Statistics, University of Northern British Columbia, Prince George, Canada, Royal Free Hospital, Scleroderma Unit, London, Scleroderma Society, Chichester, UK and Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland.
    • Assassi, S.. University of Texas Health Science Center at Houston, Houston, University of Texas Medical Branch, Galveston and University of Texas Health Science Center at San Antonio, San Antonio, USA.
    • Leyva, A.. University of Texas Health Science Center at Houston, Houston, University of Texas Medical Branch, Galveston and University of Texas Health Science Center at San Antonio, San Antonio, USA.
    • Mayes, M.. University of Texas Health Science Center at Houston, Houston, University of Texas Medical Branch, Galveston and University of Texas Health Science Center at San Antonio, San Antonio, USA.
    • Sharif, R.. University of Texas Health Science Center at Houston, Houston, University of Texas Medical Branch, Galveston and University of Texas Health Science Center at San Antonio, San Antonio, USA.
    • Nair, D.. University of Texas Health Science Center at Houston, Houston, University of Texas Medical Branch, Galveston and University of Texas Health Science Center at San Antonio, San Antonio, USA.
    • Fischbach, M.. University of Texas Health Science Center at Houston, Houston, University of Texas Medical Branch, Galveston and University of Texas Health Science Center at San Antonio, San Antonio, USA.
    • Nguyen, N.. University of Texas Health Science Center at Houston, Houston, University of Texas Medical Branch, Galveston and University of Texas Health Science Center at San Antonio, San Antonio, USA.
    • Reveille, J.. University of Texas Health Science Center at Houston, Houston, University of Texas Medical Branch, Galveston and University of Texas Health Science Center at San Antonio, San Antonio, USA.
    • Gonzalez, E.. University of Texas Health Science Center at Houston, Houston, University of Texas Medical Branch, Galveston and University of Texas Health Science Center at San Antonio, San Antonio, USA.
    • McNearney, T.. University of Texas Health Science Center at Houston, Houston, University of Texas Medical Branch, Galveston and University of Texas Health Science Center at San Antonio, San Antonio, USA.
    • Riccieri, V.. Department of Internal Medicine and Medical Specialities, University Sapienza, Rome, Italy.
    • Sciarra, I.. Department of Internal Medicine and Medical Specialities, University Sapienza, Rome, Italy.
    • Maset, L.. Department of Internal Medicine and Medical Specialities, University Sapienza, Rome, Italy.
    • Passi, L.. Department of Internal Medicine and Medical Specialities, University Sapienza, Rome, Italy.
    • Stefanantoni, K.. Department of Internal Medicine and Medical Specialities, University Sapienza, Rome, Italy.
    • Vasile, M.. Department of Internal Medicine and Medical Specialities, University Sapienza, Rome, Italy.
    • Scarno, A.. Department of Internal Medicine and Medical Specialities, University Sapienza, Rome, Italy.
    • Spadaro, A.. Department of Internal Medicine and Medical Specialities, University Sapienza, Rome, Italy.
    Type de document
    • Postprint
    Identifiant OAI-PMH
    • oai:doc.rero.ch:294140
    Summary
    Objective. We previously showed that DU significantly increased global and hand disability with a significant impact on activities of daily living (ADLs) and work disability. This study aims to evaluate the impact of digital ulcer (DU) healing on disability and daily activity limitations in SSc. Methods. From January 2008 and June 2009, we prospectively evaluated 189 SSc patients for DU history, disability, employment and occupational status during meetings of the French SSc Patient Association (n = 86, 45.5%) or during hospitalization (n = 103, 54.5%)1. Among the 60 patients with at least one active DU at baseline (M0), 40 patients were followed longitudinally over 6 (3) months. These patients were evaluated for DU history, global and hand disability, health-related quality of life (HRQoL), daily activity limitation and employment status. Results. The median (IQR) age was 57.5 (43.5-68) years and the median (IQR) disease duration was 8.3 (3-16.5) years. Twenty-two (55%) patients had diffuse SSc and 34 (85%) were females. At baseline, a mean of 2.9 (2.8) DU per patient was reported. Thirty-three (82.5%) patients had ischaemic DU, 7 (17.5%) patients had >1 DU associated with calcinosis and 13 (32.5%) patients had mechanical DU. Thirteen (32.5%) patients had >4 DU at baseline. Among the 40 patients, 16 (40%) patients showed complete ulcer healing. In these patients with DU, the presence of calcinosis was associated with a lower probability of healing (P = 0.03). Comparison between healed and no-healed DU patients showed an improvement of hand disability provided by an improvement of the Cochin Hand Function score (P = 0.05)) and a trend towards HAQ domain dressing and grooming (P = 0.06) between M0 and M6 (3) visit in healed patients but not in no-healed patients. Concerning HRQoL, there were no difference for Mental and Physical component Scores of SF-36 but significant improvement of Bodily Pain score (P = 0.04) and Physical Role score (P = 0.05) between M0 and M6 (3) visit in patients with healed DU. The absence of healing was associated with significantly decreased work productivity (P = 0.05), whereas the performance in ADL was not significantly decreased (P = 0.15). Patients who were on sick-leave and who received some help for household tasks at the time of active DU were more likely to heal. Conclusion. For the first time, we provide prospective data with evidence that DU healing is associated with an improvement in hand function. Sick leave was associated with better healing of DU