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Nonsteroidal Anti-Inflammatory Agents in the Therapy for Experimental Pneumococcal Meningitis

Tuomanen, Elaine ; Hengstler, Bruno ; Rich, Roland ; Bray, Michael A. ; Zak, Oto ; Tomasz, Alexander

In: Journal of Infectious Diseases, 1987, vol. 155, no. 5, p. 985-990

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    Titre
    • Nonsteroidal Anti-Inflammatory Agents in the Therapy for Experimental Pneumococcal Meningitis
    Auteur
    • Tuomanen, Elaine. Laboratory of Microbiology, the Rockefeller University, New York, New York, Basel, Switzerland
    • Hengstler, Bruno. Laboratory of Microbiology, the Rockefeller University, New York, New York, Basel, Switzerland
    • Rich, Roland. Laboratory of Microbiology, the Rockefeller University, New York, New York, Basel, Switzerland
    • Bray, Michael A.. Laboratory of Microbiology, the Rockefeller University, New York, New York, Basel, Switzerland
    • Zak, Oto. Laboratory of Microbiology, the Rockefeller University, New York, New York, Basel, Switzerland
    • Tomasz, Alexander. Laboratory of Microbiology, the Rockefeller University, New York, New York, Basel, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Journal of Infectious Diseases, 1987, vol. 155, no. 5, p. 985-990. The University of Chicago Press
    Autre version électronique
    Classification
    • Santé
    Identifiant OAI-PMH
    • oai:doc.rero.ch:293721
    Summary
    An increased inflammatory mass in the subarachnoid space during bacterial meningitis may correlate with a poor outcome of disease. Using a rabbit model of pneumococcal meningitis, we sought to reduce this inflammatory process. The ability of the pneumococcal cell wall to cause death and to generate leukocytosis and abnormal chemistry in cerebrospinal fluid was prevented when animals were treated with inhibitors of the cyclooxygenase pathway of arachidonate metabolism. Bacterial lysis by ampicillin led to release of cell wall that caused a significant, transient increase in meningeal inflammation. This inflammatory burst was also prevented by administering cyclooxygenase inhib-itors concurrently with the antibiotic