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Levels of Matrix Metalloproteinase-9 within Cerebrospinal Fluid in a Rabbit Model of Coccidioidal Meningitis and Vasculitis

Williams, Paul L. ; Leib, Stephen L. ; Kamberi, Perparim ; Leppert, David ; Sobel, Raymond A. ; Bifrare, Yoeng-Delphine ; Clemons, Karl V. ; Stevens, David A.

In: The Journal of Infectious Diseases, 2002, vol. 186, no. 11, p. 1692-1695

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    Titre
    • Levels of Matrix Metalloproteinase-9 within Cerebrospinal Fluid in a Rabbit Model of Coccidioidal Meningitis and Vasculitis
    Auteur
    • Williams, Paul L.. Kaweah Delta Health Care District, Visalia
    • Leib, Stephen L.. Institute for Infectious Diseases, University of Bern, Bern, and
    • Kamberi, Perparim. California Institute for Medical Research and Santa Clara Valley Medical Center, San Jose
    • Leppert, David. Department of Research, University Hospital, Basel, Switzerland
    • Sobel, Raymond A.. Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University, Stanford, and
    • Bifrare, Yoeng-Delphine. Institute for Infectious Diseases, University of Bern, Bern, and
    • Clemons, Karl V.. California Institute for Medical Research and Santa Clara Valley Medical Center, San Jose
    • Stevens, David A.. California Institute for Medical Research and Santa Clara Valley Medical Center, San Jose
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • The Journal of Infectious Diseases, 2002, vol. 186, no. 11, p. 1692-1695. The University of Chicago Press
    Autre version électronique
    Classification
    • Santé
    Identifiant OAI-PMH
    • oai:doc.rero.ch:292626
    Summary
    Matrix metalloproteinase (MMP)-9 is produced by the central nervous system and inflammatory cells in a variety of inflammatory conditions in both animals and humans. MMP-9 promotes inflammation, breakdown of the blood-brain barrier, and vasculitis. Because vasculitis is seen frequently in patients with coccidioidal meningitis (CM), this study evaluated the presence of MMP-9 within the cerebrospinal fluid (CSF) of rabbits infected intracisternally with Coccidioides immitis arthroconidia. Infected rabbits demonstrated systemic and neurological sequelae to infection, including CSF pleocytosis. Levels of MMP-9 within CSF were assayed by use of zymography and compared with MMP-2 levels, which served as an internal control. Elevated levels of MMP-9 were detectable by day 3, continued to increase through day 10, and declined by day 15 after infection. MMP-9 may contribute to inflammation and vasculitis in this animal model. Future work can focus on evaluation of MMP inhibitors, to gain a better perspective of the role of this MMP in CM