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Ageing with HIV: medication use and risk for potential drug-drug interactions

Marzolini, Catia ; Back, David ; Weber, Rainer ; Furrer, Hansjakob ; Cavassini, Matthias ; Calmy, Alexandra ; Vernazza, Pietro ; Bernasconi, Enos ; Khoo, Saye ; Battegay, Manuel ; Elzi, Luigia ; Battegay, M. ; Bernasconi, E. ; Böni, J. ; Bucher, H. C. ; Bürgisser, P. ; Calmy, A. ; Cattacin, S. ; Cavassini, M. ; Dubs, R. ; Egger, M. ; Elzi, L. ; Fischer, M. ; Flepp, M. ; Fontana, A. ; Francioli, P. ; Furrer, H. ; Fux, C. ; Gorgievski, M. ; Günthard, H. ; Hirsch, H. H. ; Hirschel, B. ; Hösli, I. ; Kahlert, Ch ; Kaiser, L. ; Karrer, U. ; Kind, C. ; Klimkait, Th ; Ledergerber, B. ; Martinetti, G. ; Martinez, B. ; Müller, N. ; Nadal, D. ; Opravil, M. ; Paccaud, F. ; Pantaleo, G. ; Rauch, A. ; Regenass, S. ; Rickenbach, M. ; Rudin, C. ; Schmid, P. ; Schultze, D. ; Schüpbach, J. ; Speck, R. ; Taffé, P. ; Tarr, P. ; Telenti, A. ; Trkola, A. ; Vernazza, P. ; Weber, R. ; Yerly, S.

In: Journal of Antimicrobial Chemotherapy, 2011, vol. 66, no. 9, p. 2107-2111

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    Titre
    • Ageing with HIV: medication use and risk for potential drug-drug interactions
    Auteur
    • Marzolini, Catia. Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland
    • Back, David. Pharmacology Research Laboratories, University of Liverpool, Liverpool, UK
    • Weber, Rainer. Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland
    • Furrer, Hansjakob. Division of Infectious Diseases, Bern University Hospital and University of Bern, Bern, Switzerland
    • Cavassini, Matthias. Division of Infectious Diseases, University Hospital Lausanne, Lausanne, Switzerland
    • Calmy, Alexandra. Division of Infectious Diseases, University Hospital Geneva, Geneva, Switzerland
    • Vernazza, Pietro. Division of Infectious Diseases and Hospital Epidemiology, Cantonal Hospital St Gallen, St Gallen, Switzerland
    • Bernasconi, Enos. Division of Infectious Diseases, Regional Hospital Lugano, Lugano, Switzerland
    • Khoo, Saye. Pharmacology Research Laboratories, University of Liverpool, Liverpool, UK
    • Battegay, Manuel. Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland
    • Elzi, Luigia. Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland
    • Battegay, M.
    • Bernasconi, E.
    • Böni, J.
    • Bucher, H. C.
    • Bürgisser, P.
    • Calmy, A.
    • Cattacin, S.
    • Cavassini, M.
    • Dubs, R.
    • Egger, M.
    • Elzi, L.
    • Fischer, M.
    • Flepp, M.
    • Fontana, A.
    • Francioli, P.
    • Furrer, H.
    • Fux, C.
    • Gorgievski, M.
    • Günthard, H.
    • Hirsch, H. H.
    • Hirschel, B.
    • Hösli, I.
    • Kahlert, Ch
    • Kaiser, L.
    • Karrer, U.
    • Kind, C.
    • Klimkait, Th
    • Ledergerber, B.
    • Martinetti, G.
    • Martinez, B.
    • Müller, N.
    • Nadal, D.
    • Opravil, M.
    • Paccaud, F.
    • Pantaleo, G.
    • Rauch, A.
    • Regenass, S.
    • Rickenbach, M.
    • Rudin, C.
    • Schmid, P.
    • Schultze, D.
    • Schüpbach, J.
    • Speck, R.
    • Taffé, P.
    • Tarr, P.
    • Telenti, A.
    • Trkola, A.
    • Vernazza, P.
    • Weber, R.
    • Yerly, S.
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Journal of Antimicrobial Chemotherapy, 2011, vol. 66, no. 9, p. 2107-2111. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:291675
    Summary
    Objectives To compare the use of co-medication, the potential drug-drug interactions (PDDIs) and the effect on antiretroviral therapy (ART) tolerability and efficacy in HIV-infected individuals according to age, ≥50 years or <50 years. Methods All ART-treated participants were prospectively included once during a follow-up visit of the Swiss HIV Cohort Study. Information on any current medication was obtained by participant self-report and medical prescription history. The complete treatment was subsequently screened for PDDIs using a customized version of the Liverpool drug interaction database. Results Drug prescriptions were analysed for 1497 HIV-infected individuals: 477 age ≥50 and 1020 age <50. Older patients were more likely to receive one or more co-medications compared with younger patients (82% versus 61%; P < 0.001) and thus had more frequent PDDIs (51% versus 35%; P < 0.001). Furthermore, older patients tended to use a higher number of co-medications and certain therapeutic drug classes more often, such as cardiovascular drugs (53% versus 19%; P < 0.001), gastrointestinal medications (10% versus 6%; P = 0.004) and hormonal agents (6% versus 3%; P = 0.04). PDDIs with ART occurred mainly with cardiovascular drugs (27%), CNS agents (22%) and methadone (6%) in older patients and with CNS agents (27%), methadone (15%) and cardiovascular drugs (11%) in younger patients. The response to ART did not differ between the two groups. Conclusions The risk for PDDIs with ART increased in older patients who take more drugs than their younger HIV-infected counterparts. However, medication use in older and younger patients did not differ in terms of effect on antiretroviral tolerability and response