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International Guidelines for Management of Metastatic Breast Cancer: Can Metastatic Breast Cancer Be Cured?

Pagani, Olivia ; Senkus, Elżbieta ; Wood, William ; Colleoni, Marco ; Cufer, Tanja ; Kyriakides, Stella ; Costa, Alberto ; Winer, Eric P. ; Cardoso, Fatima

In: Journal of the National Cancer Institute, 2010, vol. 102, no. 7, p. 456-463

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    Titre
    • International Guidelines for Management of Metastatic Breast Cancer: Can Metastatic Breast Cancer Be Cured?
    Auteur
    • Pagani, Olivia. Affiliations of authors: Oncology Institute of Southern Switzerland, Ospedale Italiano, Viganello, Lugano, Switzerland (OP); Swiss Group for Clinical Cancer Research (SAKK), Bern, Switzerland (OP); Department of Oncology and Radiotherapy, Medical University of Gdańsk, Gdańsk, Poland (ES); Department of Surgery, Emory University School of Medicine, Atlanta, GA (WW); Medical Senology Research Unit, European Institute of Oncology, Milan, Italy (MC); Department of Medical Oncology, University Clinic Golnik, Golnik, Slovenia (TC); European Breast Cancer Coalition, Nicosia, Cyprus (SK); European School of Oncology, Milan, Italy (AC); Maugeri Foundation Breast Unit, Pavia, Italy (AC); Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (EPW); Department of Medical Oncology, Jules Bordet Institute, Brussels, Belgium (FC)
    • Senkus, Elżbieta. Affiliations of authors: Oncology Institute of Southern Switzerland, Ospedale Italiano, Viganello, Lugano, Switzerland (OP); Swiss Group for Clinical Cancer Research (SAKK), Bern, Switzerland (OP); Department of Oncology and Radiotherapy, Medical University of Gdańsk, Gdańsk, Poland (ES); Department of Surgery, Emory University School of Medicine, Atlanta, GA (WW); Medical Senology Research Unit, European Institute of Oncology, Milan, Italy (MC); Department of Medical Oncology, University Clinic Golnik, Golnik, Slovenia (TC); European Breast Cancer Coalition, Nicosia, Cyprus (SK); European School of Oncology, Milan, Italy (AC); Maugeri Foundation Breast Unit, Pavia, Italy (AC); Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (EPW); Department of Medical Oncology, Jules Bordet Institute, Brussels, Belgium (FC)
    • Wood, William. Affiliations of authors: Oncology Institute of Southern Switzerland, Ospedale Italiano, Viganello, Lugano, Switzerland (OP); Swiss Group for Clinical Cancer Research (SAKK), Bern, Switzerland (OP); Department of Oncology and Radiotherapy, Medical University of Gdańsk, Gdańsk, Poland (ES); Department of Surgery, Emory University School of Medicine, Atlanta, GA (WW); Medical Senology Research Unit, European Institute of Oncology, Milan, Italy (MC); Department of Medical Oncology, University Clinic Golnik, Golnik, Slovenia (TC); European Breast Cancer Coalition, Nicosia, Cyprus (SK); European School of Oncology, Milan, Italy (AC); Maugeri Foundation Breast Unit, Pavia, Italy (AC); Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (EPW); Department of Medical Oncology, Jules Bordet Institute, Brussels, Belgium (FC)
    • Colleoni, Marco. Affiliations of authors: Oncology Institute of Southern Switzerland, Ospedale Italiano, Viganello, Lugano, Switzerland (OP); Swiss Group for Clinical Cancer Research (SAKK), Bern, Switzerland (OP); Department of Oncology and Radiotherapy, Medical University of Gdańsk, Gdańsk, Poland (ES); Department of Surgery, Emory University School of Medicine, Atlanta, GA (WW); Medical Senology Research Unit, European Institute of Oncology, Milan, Italy (MC); Department of Medical Oncology, University Clinic Golnik, Golnik, Slovenia (TC); European Breast Cancer Coalition, Nicosia, Cyprus (SK); European School of Oncology, Milan, Italy (AC); Maugeri Foundation Breast Unit, Pavia, Italy (AC); Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (EPW); Department of Medical Oncology, Jules Bordet Institute, Brussels, Belgium (FC)
    • Cufer, Tanja. Affiliations of authors: Oncology Institute of Southern Switzerland, Ospedale Italiano, Viganello, Lugano, Switzerland (OP); Swiss Group for Clinical Cancer Research (SAKK), Bern, Switzerland (OP); Department of Oncology and Radiotherapy, Medical University of Gdańsk, Gdańsk, Poland (ES); Department of Surgery, Emory University School of Medicine, Atlanta, GA (WW); Medical Senology Research Unit, European Institute of Oncology, Milan, Italy (MC); Department of Medical Oncology, University Clinic Golnik, Golnik, Slovenia (TC); European Breast Cancer Coalition, Nicosia, Cyprus (SK); European School of Oncology, Milan, Italy (AC); Maugeri Foundation Breast Unit, Pavia, Italy (AC); Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (EPW); Department of Medical Oncology, Jules Bordet Institute, Brussels, Belgium (FC)
    • Kyriakides, Stella. Affiliations of authors: Oncology Institute of Southern Switzerland, Ospedale Italiano, Viganello, Lugano, Switzerland (OP); Swiss Group for Clinical Cancer Research (SAKK), Bern, Switzerland (OP); Department of Oncology and Radiotherapy, Medical University of Gdańsk, Gdańsk, Poland (ES); Department of Surgery, Emory University School of Medicine, Atlanta, GA (WW); Medical Senology Research Unit, European Institute of Oncology, Milan, Italy (MC); Department of Medical Oncology, University Clinic Golnik, Golnik, Slovenia (TC); European Breast Cancer Coalition, Nicosia, Cyprus (SK); European School of Oncology, Milan, Italy (AC); Maugeri Foundation Breast Unit, Pavia, Italy (AC); Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (EPW); Department of Medical Oncology, Jules Bordet Institute, Brussels, Belgium (FC)
    • Costa, Alberto. Affiliations of authors: Oncology Institute of Southern Switzerland, Ospedale Italiano, Viganello, Lugano, Switzerland (OP); Swiss Group for Clinical Cancer Research (SAKK), Bern, Switzerland (OP); Department of Oncology and Radiotherapy, Medical University of Gdańsk, Gdańsk, Poland (ES); Department of Surgery, Emory University School of Medicine, Atlanta, GA (WW); Medical Senology Research Unit, European Institute of Oncology, Milan, Italy (MC); Department of Medical Oncology, University Clinic Golnik, Golnik, Slovenia (TC); European Breast Cancer Coalition, Nicosia, Cyprus (SK); European School of Oncology, Milan, Italy (AC); Maugeri Foundation Breast Unit, Pavia, Italy (AC); Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (EPW); Department of Medical Oncology, Jules Bordet Institute, Brussels, Belgium (FC)
    • Winer, Eric P.. Affiliations of authors: Oncology Institute of Southern Switzerland, Ospedale Italiano, Viganello, Lugano, Switzerland (OP); Swiss Group for Clinical Cancer Research (SAKK), Bern, Switzerland (OP); Department of Oncology and Radiotherapy, Medical University of Gdańsk, Gdańsk, Poland (ES); Department of Surgery, Emory University School of Medicine, Atlanta, GA (WW); Medical Senology Research Unit, European Institute of Oncology, Milan, Italy (MC); Department of Medical Oncology, University Clinic Golnik, Golnik, Slovenia (TC); European Breast Cancer Coalition, Nicosia, Cyprus (SK); European School of Oncology, Milan, Italy (AC); Maugeri Foundation Breast Unit, Pavia, Italy (AC); Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (EPW); Department of Medical Oncology, Jules Bordet Institute, Brussels, Belgium (FC)
    • Cardoso, Fatima. Affiliations of authors: Oncology Institute of Southern Switzerland, Ospedale Italiano, Viganello, Lugano, Switzerland (OP); Swiss Group for Clinical Cancer Research (SAKK), Bern, Switzerland (OP); Department of Oncology and Radiotherapy, Medical University of Gdańsk, Gdańsk, Poland (ES); Department of Surgery, Emory University School of Medicine, Atlanta, GA (WW); Medical Senology Research Unit, European Institute of Oncology, Milan, Italy (MC); Department of Medical Oncology, University Clinic Golnik, Golnik, Slovenia (TC); European Breast Cancer Coalition, Nicosia, Cyprus (SK); European School of Oncology, Milan, Italy (AC); Maugeri Foundation Breast Unit, Pavia, Italy (AC); Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (EPW); Department of Medical Oncology, Jules Bordet Institute, Brussels, Belgium (FC)
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Journal of the National Cancer Institute, 2010, vol. 102, no. 7, p. 456-463. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:291645
    Summary
    A distinctive subset of metastatic breast cancer (MBC) is oligometastatic disease, which is characterized by single or few detectable metastatic lesions. The existing treatment guidelines for patients with localized MBC include surgery, radiotherapy, and regional chemotherapy. The European School of Oncology-Metastatic Breast Cancer Task Force addressed the management of these patients in its first consensus recommendations published in 2007. The Task Force endorsed the possibility of a more aggressive and multidisciplinary approach for patients with oligometastatic disease, stressing also the need for clinical trials in this patient population. At the sixth European Breast Cancer Conference, held in Berlin in March 2008, the second public session on MBC guidelines addressed the controversial issue of whether MBC can be cured. In this commentary, we summarize the discussion and related recommendations regarding the available therapeutic options that are possibly associated with cure in these patients. In particular, data on local (surgery and radiotherapy) and chemotherapy options are discussed. Large retrospective series show an association between surgical removal of the primary tumor or of lung metastases and improved long-term outcome in patients with oligometastatic disease. In the absence of data from prospective randomized studies, removal of the primary tumor or isolated metastatic lesions may be an attractive therapeutic strategy in this subset of patients, offering rapid disease control and potential for survival benefit. Some improvement in outcome may also be achieved with optimization of systemic therapies, possibly in combination with optimal local treatment