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EFFECT OF METHYLENE BLUE ON THE DISPOSITION OF ETHANOL

Vonlanthen, Ronald ; Beer, Jürg H. ; Lauterburg, Bernhard H.

In: Alcohol and Alcoholism, 2000, vol. 35, no. 5, p. 424-426

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    Titre
    • EFFECT OF METHYLENE BLUE ON THE DISPOSITION OF ETHANOL
    Auteur
    • Vonlanthen, Ronald
    • Beer, Jürg H.
    • Lauterburg, Bernhard H.. Department of Clinical Pharmacology, University of Bern, Murtenstrasse 35, CH-3010 Bern, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Alcohol and Alcoholism, 2000, vol. 35, no. 5, p. 424-426. Oxford University Press
    Autre version électronique
    Classification
    • Santé
    Identifiant OAI-PMH
    • oai:doc.rero.ch:291629
    Summary
    The effect of methylene blue on the disposition of ethanol was studied in rats and humans. Methylene blue increased the metabolism of [14C]ethanol to 14CO2 in isolated hepatocytes and in intact rats by 75% and 30%, respectively. In healthy volunteers, methylene blue did not affect the pharmacokinetics of ethanol and did not alleviate the ethanol-induced NAD redox changes as reflected by the increase in the [lactate]/[pyruvate] ratio