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Studies on Trypanosoma (nannomonas) congolense: IV. Experimental immunization of mice against tsetse fly Challenge

Nantulya, V. M. ; Doyle, J. J. ; Jenni, L.

In: Parasitology, 1980, vol. 80, no. 1, p. 133-137

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    Titre
    • Studies on Trypanosoma (nannomonas) congolense: IV. Experimental immunization of mice against tsetse fly Challenge
    Auteur
    • Nantulya, V. M.. International Laboratory for Research on Animal Diseases (ILRAD), P.O. Box 30709, Nairobi, Kenya
    • Doyle, J. J.. International Laboratory for Research on Animal Diseases (ILRAD), P.O. Box 30709, Nairobi, Kenya
    • Jenni, L.. Swiss Tropical Institute, Basle, Switzerland
    Type de document
    • Postprint
    Classification
    • Santé
    Identifiant OAI-PMH
    • oai:doc.rero.ch:291356
    Summary
    Groups of mice were exposed to multiple bites by tsetse flies (Glossina morsitans morsitans) infected with a clone of Trypanosoma congolense spread over a period of 8 days. The mice were subsequently treated with Berenil 10 days after the first fly bite as were uninfected control mice. The group of mice which received 12-15 infectious fly bites on two occasions, 21 days apart, were subsequently resistant to infection when re-challenged by flies infected with the same clone of T. congolense. These mice were also immune to challenge by flies infected with a different bloodstream variable antigen type derived from this same stock. The immunity was stock-specific and directed against the metacyclic forms of the parasite, but was short-lived