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Chitinase 3-like 1: prognostic biomarker in clinically isolated syndromes

Cantó, Ester ; Tintoré, Mar ; Villar, Luisa M. ; Costa, Carme ; Nurtdinov, Ramil ; Álvarez-Cermeño, José C. ; Arrambide, Georgina ; Reverter, Ferran ; Deisenhammer, Florian ; Hegen, Harald ; Khademi, Mohsen ; Olsson, Tomas ; Tumani, Hayrettin ; Rodríguez-Martín, Eulalia ; Piehl, Fredrik ; Bartos, Ales ; Zimova, Denisa ; Kotoucova, Jolana ; Kuhle, Jens ; Kappos, Ludwig ; García-Merino, Juan Antonio ; Sánchez, Antonio José ; Saiz, Albert ; Blanco, Yolanda ; Hintzen, Rogier ; Jafari, Naghmeh ; Brassat, David ; Lauda, Florian ; Roesler, Romy ; Rejdak, Konrad ; Papuc, Ewa ; de Andrés, Clara ; Rauch, Stefan ; Khalil, Michael ; Enzinger, Christian ; Galimberti, Daniela ; Scarpini, Elio ; Teunissen, Charlotte ; Sánchez, Alex ; Rovira, Alex ; Montalban, Xavier ; Comabella, Manuel

In: Brain, 2015, vol. 138, no. 4, p. 918-931

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    Titel
    • Chitinase 3-like 1: prognostic biomarker in clinically isolated syndromes
    Autor
    • Cantó, Ester. 1 Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain
    • Tintoré, Mar. 1 Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain
    • Villar, Luisa M.. 2 Departments of Neurology and Immunology, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigacion sanitaria, Madrid, Spain
    • Costa, Carme. 1 Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain
    • Nurtdinov, Ramil. 1 Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain
    • Álvarez-Cermeño, José C.. 2 Departments of Neurology and Immunology, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigacion sanitaria, Madrid, Spain
    • Arrambide, Georgina. 1 Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain
    • Reverter, Ferran. 3 Departament d'Estadística, Facultat de Biologia, Universitat de Barcelona, Barcelona
    • Deisenhammer, Florian. 4 Department of Clinical Neurology, Innsbruck Medical University, Innsbruck, Austria
    • Hegen, Harald. 4 Department of Clinical Neurology, Innsbruck Medical University, Innsbruck, Austria
    • Khademi, Mohsen. 5 Neuroimmunology Unit Department of Clinical Neuroscience, Karolinska Institutet at Karolinska University Hospital, Solna, Sweden
    • Olsson, Tomas. 5 Neuroimmunology Unit Department of Clinical Neuroscience, Karolinska Institutet at Karolinska University Hospital, Solna, Sweden
    • Tumani, Hayrettin. 6 Department of Neurology, CSF Laboratory and MS Outpatient Unit, University of Ulm, Germany
    • Rodríguez-Martín, Eulalia. 2 Departments of Neurology and Immunology, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigacion sanitaria, Madrid, Spain
    • Piehl, Fredrik. 5 Neuroimmunology Unit Department of Clinical Neuroscience, Karolinska Institutet at Karolinska University Hospital, Solna, Sweden
    • Bartos, Ales. 7 Charles University in Prague, Third Faculty of Medicine and University Hospital Kralovske Vinohrady, Department of Neurology, Šrobárova 50, 100 34 Prague 10, Czech Republic
    • Zimova, Denisa. 7 Charles University in Prague, Third Faculty of Medicine and University Hospital Kralovske Vinohrady, Department of Neurology, Šrobárova 50, 100 34 Prague 10, Czech Republic
    • Kotoucova, Jolana. 7 Charles University in Prague, Third Faculty of Medicine and University Hospital Kralovske Vinohrady, Department of Neurology, Šrobárova 50, 100 34 Prague 10, Czech Republic
    • Kuhle, Jens. 8 Neurology and Clinical Neuroimmunology, University Hospital, University of Basel, Basel, Switzerland
    • Kappos, Ludwig. 8 Neurology and Clinical Neuroimmunology, University Hospital, University of Basel, Basel, Switzerland
    • García-Merino, Juan Antonio. 9 Neuroimmunology Unit and Neurology Service, Hospital Universitario Puerta de Hierro, Madrid, Spain
    • Sánchez, Antonio José. 9 Neuroimmunology Unit and Neurology Service, Hospital Universitario Puerta de Hierro, Madrid, Spain
    • Saiz, Albert. 10 Service of Neurology, Hospital Clínic, Universitat de Barcelona and Institut d́Investigació Biomèdica August Pi i Sunyer (IDIBAPS), Barcelona, Spain
    • Blanco, Yolanda. 10 Service of Neurology, Hospital Clínic, Universitat de Barcelona and Institut d́Investigació Biomèdica August Pi i Sunyer (IDIBAPS), Barcelona, Spain
    • Hintzen, Rogier. 11 Department of Neurology, Erasmus University Medical Centre, Rotterdam, The Netherlands
    • Jafari, Naghmeh. 11 Department of Neurology, Erasmus University Medical Centre, Rotterdam, The Netherlands
    • Brassat, David. 12 Pole des Neurosciences and UMR 1043, Hôpital Purpan, Université de Toulouse III, Toulouse, France
    • Lauda, Florian. 6 Department of Neurology, CSF Laboratory and MS Outpatient Unit, University of Ulm, Germany
    • Roesler, Romy. 6 Department of Neurology, CSF Laboratory and MS Outpatient Unit, University of Ulm, Germany
    • Rejdak, Konrad. 13 Department of Neurology, Medical University of Lublin, Lublin, Poland
    • Papuc, Ewa. 13 Department of Neurology, Medical University of Lublin, Lublin, Poland
    • de Andrés, Clara. 15 Department of Neurology, Hospital General Universitario Gregorio Marañón, Madrid, Spain
    • Rauch, Stefan. 16 Department of Radiology, Innsbruck Medical University, Innsbruck, Austria
    • Khalil, Michael. 17 Department of Neurology, Medical University of Graz, Graz, Austria
    • Enzinger, Christian. 17 Department of Neurology, Medical University of Graz, Graz, Austria
    • Galimberti, Daniela. 18 Neurology Unit, Department of Pathophysiology and Transplantation, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy
    • Scarpini, Elio. 18 Neurology Unit, Department of Pathophysiology and Transplantation, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy
    • Teunissen, Charlotte. 19 BIoMS-eu Network and Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry, VU University Medical Centre, Amsterdam, The Netherlands
    • Sánchez, Alex. 3 Departament d'Estadística, Facultat de Biologia, Universitat de Barcelona, Barcelona
    • Rovira, Alex. 21 Unitat de RM. Servei de Radiologia, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain
    • Montalban, Xavier. 1 Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain
    • Comabella, Manuel. 1 Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain
    Dokumententyp
    • Postprint
    Sprache
    • Englisch
    Veröffentlicht in
    • Brain, 2015, vol. 138, no. 4, p. 918-931. Oxford University Press
    Andere elektronische Ausgabe
    OAI-PMH-ID
    • oai:doc.rero.ch:291298
    Summary
    Prognostic molecular biomarkers for the conversion of clinically isolated syndrome (CIS) to multiple sclerosis (MS) are lacking. In a prospective longitudinal study of 813 individuals with CIS, Cantó et al. validate elevated CSF levels of chitinase 3-like 1 as a biomarker for conversion to MS and development of disability