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Foreign Body Infection: Role of Fibronectin as a Ligand for the Adherence of Staphylococcus aureus

Vaudaux, P. ; Suzuki, R. ; Waldvogel, F. A. ; Morgenthaler, J. J. ; Nydegger, U. E.

In: Journal of Infectious Diseases, 1984, vol. 150, no. 4, p. 546-553

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    Titre
    • Foreign Body Infection: Role of Fibronectin as a Ligand for the Adherence of Staphylococcus aureus
    Auteur
    • Vaudaux, P.. Division of Infectious Diseases, Department of Medicine, University Hospital, Geneva, Bern, Switzerland
    • Suzuki, R.. Division of Infectious Diseases, Department of Medicine, University Hospital, Geneva, Bern, Switzerland
    • Waldvogel, F. A.. Division of Infectious Diseases, Department of Medicine, University Hospital, Geneva, Bern, Switzerland
    • Morgenthaler, J. J.. Division of Infectious Diseases, Department of Medicine, University Hospital, Geneva, Bern, Switzerland
    • Nydegger, U. E.. Division of Infectious Diseases, Department of Medicine, University Hospital, Geneva, Bern, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Journal of Infectious Diseases, 1984, vol. 150, no. 4, p. 546-553. The University of Chicago Press
    Autre version électronique
    Classification
    • Santé
    Identifiant OAI-PMH
    • oai:doc.rero.ch:291076
    Summary
    Foreign bodies made of polymethylmethacrylate coverslips were implanted subcutaneously into guinea pigs, were explanted four weeks later, and were tested for in vitro adherence of Staphylococcus aureus strain Wood 46. In the presence of serum, the level of staphylococcal adherence to explanted coverslips was 20 times higher than that of adherence to unimplanted coverslips. Adherence to explanted coverslips was caused by fibronectin deposits on the foreign body surface and was inhibited in a dose-related fashion by specific antibodies to fibronectin