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Dynamics of Anemia in Relation to Parasitic Infections, Micronutrient Status, and Increasing Age in South-Central Côte d'Ivoire

Righetti, Aurélie A. ; Adiossan, Lukas G. ; Ouattara, Mamadou ; Glinz, Dominik ; Hurrell, Richard F. ; N'Goran, Eliézer K. ; Wegmüller, Rita ; Utzinger, Jürg

In: The Journal of Infectious Diseases, 2013, vol. 207, no. 10, p. 1604-1615

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    Titre
    • Dynamics of Anemia in Relation to Parasitic Infections, Micronutrient Status, and Increasing Age in South-Central Côte d'Ivoire
    Auteur
    • Righetti, Aurélie A.. Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute
    • Adiossan, Lukas G.. Hôpital Général de Taabo, Taabo Cité
    • Ouattara, Mamadou. Unité de Formation et de Recherche Biosciences, Université Félix Houphouët-Boigny, Abidjan, Côte d'Ivoire
    • Glinz, Dominik. Laboratory of Human Nutrition, Institute of Food, Nutrition, and Health, ETH Zurich, Zurich, Switzerland
    • Hurrell, Richard F.. Laboratory of Human Nutrition, Institute of Food, Nutrition, and Health, ETH Zurich, Zurich, Switzerland
    • N'Goran, Eliézer K.. Unité de Formation et de Recherche Biosciences, Université Félix Houphouët-Boigny, Abidjan, Côte d'Ivoire
    • Wegmüller, Rita. Laboratory of Human Nutrition, Institute of Food, Nutrition, and Health, ETH Zurich, Zurich, Switzerland
    • Utzinger, Jürg. Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • The Journal of Infectious Diseases, 2013, vol. 207, no. 10, p. 1604-1615. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:290154
    Summary
    Background. Parasitic diseases (eg, malaria and helminthiases) exert enormous burdens on public health and social well-being. Moreover, parasitic infections are important causes of anemia in tropical Africa, exacerbated by lack of a diversified diet and inflammatory and genetic diseases. There is a paucity of longitudinal studies monitoring the dynamics of anemia in relation to the aforementioned parameters. Methods. We designed a 14-month prospective longitudinal study in 3 cohorts (ie, infants aged 6-23 months, children aged 6-8 years, and women aged 15-25 years) in the Taabo health demographic surveillance system located in south-central Côte d'Ivoire. Parasitological, hematological, and micronutrient data were obtained from repeated cross-sectional surveys, utilizing standardized, quality-controlled methods. Results. We found that young age, Plasmodium and Schistosoma infections, cellular iron deficiency, and stunting were significantly negatively associated with hemoglobin concentration. Moreover, iron status biomarkers (ie, ferritin and soluble transferrin receptor) were significantly associated with inflammatory parameters. Conclusions. Based on our results, effective prevention and control measures that target parasitic diseases and iron deficiency are needed. These measures might include the distribution of long-lasting insecticidal nets, intermittent preventive treatment for malaria, regular anthelmintic drug administration, and improved intake of bioavailable iron, coupled with health and nutritional education and improved hygiene, water, and sanitation