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Descriptive epidemiology of vulvar and vaginal cancers in Vaud, Switzerland, 1974-1994

Levi, F. ; Randimbison, L. ; La Vecchia, C.

In: Annals of Oncology, 1998, vol. 9, no. 11, p. 1229-1232

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    Titre
    • Descriptive epidemiology of vulvar and vaginal cancers in Vaud, Switzerland, 1974-1994
    Auteur
    • Levi, F.. Registre vaudois des tumeurs, Institut universitaire de médecine sociale el préventive, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland, Milano, Italy
    • Randimbison, L.. Registre vaudois des tumeurs, Institut universitaire de médecine sociale el préventive, Centre Hospitalier Universitaire Vaudois Lausanne, Switzerland
    • La Vecchia, C.. Istituto di Ricerche Farmacologiche ‘Mario Negri', and Istituto di Stalistica Medica e Biometria, Università degli Studi di Milano Milano, Italy
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Annals of Oncology, 1998, vol. 9, no. 11, p. 1229-1232. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:290145
    Summary
    Background: To analyse trends in incidence, survival and risk of second neoplasms following vaginal and vulvar cancers using data collected by the Swiss Cancer Registry of Vaud over the 21-year period 1974-1994. Materials and methods: Subjects were 257 vulvo-vaginal cancers. Of these, 69 were vaginal, 153 vulvar cancers, and 35 non-specified lower genital tract neoplasms; 94 in situ neoplasms were also registered (85 for the vulva). Results: Invasive vaginal cancer incidence decreased from 0.8 in 1974-1984 to 0.4/100,000 women in 1985-1994, while invasive vulvar cancer incidence remained approximately stable around 1.2/100,000 (world standard); incidence of in situ vulvar cancer increased from 0.8 to 1.3/100,000, the rise being larger in younger women. Significant excesses for second primary neoplasms were observed for oro-pharyngeal and lung cancer, and for non-melanomatous skin neoplasms, as well as for invasive vulvar cancers following in situ cancers. Conclusions: This population-based dataset confirms that the incidence of in situ vulvar (but not invasive vulvar or vaginal cancer) has been increasing over the last 20 years. The excess second primary neoplasms supports the hypotheses that human papillomavirus and cigarette smoking are related to vulvo-vaginal neoplasms