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Ultrasound-assisted thrombolysis for acute pulmonary embolism: a systematic review

Engelberger, Rolf P. ; Kucher, Nils

In: European Heart Journal, 2014, vol. 35, no. 12, p. 758-764

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    Titre
    • Ultrasound-assisted thrombolysis for acute pulmonary embolism: a systematic review
    Auteur
    • Engelberger, Rolf P.. Clinic for Angiology, Swiss Cardiovascular Center, Inselspital, University Hospital, University of Bern, 3010 Bern, Switzerland
    • Kucher, Nils. Clinic for Angiology, Swiss Cardiovascular Center, Inselspital, University Hospital, University of Bern, 3010 Bern, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • European Heart Journal, 2014, vol. 35, no. 12, p. 758-764. Oxford University Press
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:289660
    Summary
    Pulmonary embolism remains a common and potentially life-threatening disease. For patients with intermediate- and high-risk pulmonary embolism, catheter-based revascularization therapy has emerged as potential alternative to systemic thrombolysis or surgical embolectomy. Ultrasound-assisted catheter-directed thrombolysis is a contemporary catheter-based technique and is the focus of the present review. Ultrasound-assisted catheter-directed thrombolysis is more effective in reversing right ventricular dysfunction and dilatation in comparison with anticoagulation alone in patients at intermediate risk. However, a direct comparison of ultrasound-assisted thrombolysis with systemic thrombolysis or surgical thrombectomy is not available. Ultrasound-assisted thrombolysis with initial intrapulmonary thrombolytic bolus may also be effective in high-risk patients, but evidence from randomized trials is not available. This review summarizes current data on ultrasound-assisted thrombolysis for acute pulmonary embolism