Lack of multiple copies of pfmdr1 gene in Papua New Guinea
Hodel, Eva Maria ; Marfurt, Jutta ; Müller, Dania ; Rippert, Anja ; Borrmann, Steffen ; Müller, Ivo ; Reeder, John C. ; Siba, Peter ; Genton, Blaise ; Beck, Hans-Peter
In: Transactions of The Royal Society of Tropical Medicine and Hygiene, 2008, vol. 102, no. 11, p. 1151-1153
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- We describe here the results of an analysis of Plasmodium falciparum multidrug resistance protein 1 (pfmdr1) gene copy number from 440 field isolates from Papua New Guinea. No multiple copies of the gene were found, which corresponds to the lack of usage of mefloquine. These data extend regional knowledge about the distribution of multidrug-resistant P. falciparum