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Lack of multiple copies of pfmdr1 gene in Papua New Guinea

Hodel, Eva Maria ; Marfurt, Jutta ; Müller, Dania ; Rippert, Anja ; Borrmann, Steffen ; Müller, Ivo ; Reeder, John C. ; Siba, Peter ; Genton, Blaise ; Beck, Hans-Peter

In: Transactions of The Royal Society of Tropical Medicine and Hygiene, 2008, vol. 102, no. 11, p. 1151-1153

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    Titel
    • Lack of multiple copies of pfmdr1 gene in Papua New Guinea
    Autor
    • Hodel, Eva Maria. Swiss Tropical Institute, Socinstrasse 57, P.O. Box 4002 Basle, Switzerland
    • Marfurt, Jutta. Swiss Tropical Institute, Socinstrasse 57, P.O. Box 4002 Basle, Switzerland
    • Müller, Dania. Swiss Tropical Institute, Socinstrasse 57, P.O. Box 4002 Basle, Switzerland
    • Rippert, Anja. Institute of Hygiene, University of Heidelberg School of Medicine, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany
    • Borrmann, Steffen. Institute of Hygiene, University of Heidelberg School of Medicine, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany
    • Müller, Ivo. Papua New Guinea Institute of Medical Research, P.O. Box 60, Goroka, EHP 411, Papua New Guinea
    • Reeder, John C.. Papua New Guinea Institute of Medical Research, P.O. Box 60, Goroka, EHP 411, Papua New Guinea
    • Siba, Peter. Papua New Guinea Institute of Medical Research, P.O. Box 60, Goroka, EHP 411, Papua New Guinea
    • Genton, Blaise. Swiss Tropical Institute, Socinstrasse 57, P.O. Box 4002 Basle, Switzerland
    • Beck, Hans-Peter. Swiss Tropical Institute, Socinstrasse 57, P.O. Box 4002 Basle, Switzerland
    Dokumententyp
    • Postprint
    Sprache
    • Englisch
    Veröffentlicht in
    • Transactions of The Royal Society of Tropical Medicine and Hygiene, 2008, vol. 102, no. 11, p. 1151-1153. Royal Society of Tropical Medicine and Hygiene
    Andere elektronische Ausgabe
    OAI-PMH-ID
    • oai:doc.rero.ch:289646
    Summary
    We describe here the results of an analysis of Plasmodium falciparum multidrug resistance protein 1 (pfmdr1) gene copy number from 440 field isolates from Papua New Guinea. No multiple copies of the gene were found, which corresponds to the lack of usage of mefloquine. These data extend regional knowledge about the distribution of multidrug-resistant P. falciparum