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SYNOVIAL FLUID AND SERUM ANTIBODIES AGAINST CHLAMYDIA IN DIFFERENT FORMS OF ARTHRITIS: INTRA-ARTICULAR IgA PRODUCTION IN CHLAMYDIA SEXUALLY ACQUIRED REACTIVE ARTHRITIS

BAS, S. ; CUNNINGHAM, T. ; KVIEN, T. K. ; GLENNÅS, A. ; MELBY, K. ; VISCHER, T. L.

In: Rheumatology, 1996, vol. 35, no. 6, p. 548-552

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    Titre
    • SYNOVIAL FLUID AND SERUM ANTIBODIES AGAINST CHLAMYDIA IN DIFFERENT FORMS OF ARTHRITIS: INTRA-ARTICULAR IgA PRODUCTION IN CHLAMYDIA SEXUALLY ACQUIRED REACTIVE ARTHRITIS
    Auteur
    • BAS, S.. Division of Rheumatology, University Hospital Geneva, Switzerland
    • CUNNINGHAM, T.. Division of Rheumatology, University Hospital Geneva, Switzerland
    • KVIEN, T. K.. Oslo City Department of Rheumatology, Norwegian Lutheran Hospital Oslo
    • GLENNÅS, A.. Oslo City Department of Rheumatology, Norwegian Lutheran Hospital Oslo
    • MELBY, K.. Department of Microbiology, UllevÅl University Hospital Oslo, Norway
    • VISCHER, T. L.. Division of Rheumatology, University Hospital Geneva, Switzerland
    Type de document
    • Postprint
    Identifiant OAI-PMH
    • oai:doc.rero.ch:289375
    Summary
    SUMMARY Since the presence of Chlamydia has been shown in synovial fluid (SF) from some patients with Chlamydia reactive arthritis, we investigated whether anti-Chlamydia antibodies present in the joint are derived from the circulation or are locally produced. We compared titres of IgG, IgM and IgA antibodies against Chlamydia, and against a control antigen (tetanus toxoid), by an enzyme-linked immunosorbent assay (ELISA), in paired samples of serum and SF from Chlamydia trachomatis sexually acquired reactive arthritis (CT-SARA) patients and from patients with other forms of arthritis. The ratio of serum/SF IgA anti-Chlamydia antibodies was significantly decreased in CT-SARA patients. It is concluded that, in our experimental conditions, we found evidence for intra-articular production of IgA anti-Chlamydia antibodies