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The Mi-2 nucleosome-remodeling protein LET-418 is targeted via LIN-1/ETS to the promoter of lin-39/Hox during vulval development in C. elegans

Guerry, Frédéric ; Marti, Claude-Olivier ; Zhang, Yue ; Moroni, Paolo S. ; Jaquiéry, Emilie ; Müller, Fritz

In: Developmental Biology, 2007, vol. 206, no. 2, p. 469-479

The fate of the vulval cells in Caenorhabditis elegans is specified, at least in part, through a highly conserved RTK/Ras mediated signaling cascade that negatively regulates the activity of the ETS-like transcription factor LIN-1. The Hox gene lin-39 functions downstream of both, the LIN-3/RTK/Ras pathway and LIN-1 and plays a pivotal role in controlling vulva cell competence and...