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    Université de Fribourg

    A simple reaction for dna sensing and chemical delivery

    Janett, Elia ; Diep, Kim-Long ; Fromm, Katharina M. ; Bochet, Christian G.

    In: ACS Sensors, 2020, vol. 5, no. 8, p. 2338–2343

    Reactions templated by nucleic acids are currently at the heart of applications in biosensing and drug release. The number of chemical reactions selectively occurring only in the presence of the template, in aqueous solutions, and at room temperature and able to release a chemical moiety is still very limited. Here, we report the use of the p-nitrophenyl carbonate (NPC) as a new reactive...

    Université de Fribourg

    Synthesis of FMRFaNV, a photoreleasable caged transmitter designed to study neuron–glia interactions in the central nervous System

    Janett, Elia ; Bernardinelli, Yann ; Müller, Dominique ; Bochet, Christian G.

    In: Bioconjugate Chemistry, 2015, vol. 26, no. 12, p. 2408–2418

    Neuroscience studies require technologies able to deliver compounds with both scale and timing compatibility with morphological and physiological synaptic properties. In this light, two-photon flash photolysis has been extensively used to successfully apply glutamate or other neurotransmitters at the synaptic level. However, the set of commercially available caged compounds is restricted and...