Université de Fribourg

Fate of rubrospinal neurons after unilateral section of the cervical spinal cord in adult macaque monkeys: Effects of an antibody treatment neutralizing Nogo-A

Wannier-Morino, Patrizia ; Schmidlin, Eric ; Freund, Patrick ; Belhaj-Saif, Abderraouf ; Bloch, Jocelyne ; Mir, Anis ; Schwab, Martin E. ; Rouiller, Eric M. ; Wannier, Tierry

In: Brain Research, 2008, vol. 1217, p. 96-109

The present study describes in primates the effects of a spinal cord injury on the number and size of the neurons in the magnocellular part of the red nucleus (RNm), the origin of the rubrospinal tract, and evaluates whether a neutralization of Nogo-A reduces the lesioned-induced degenerative processes observed in RNm. Two groups of monkeys were subjected to unilateral section of the spinal cord...

Université de Fribourg

Nogo-A–specific antibody treatment enhances sprouting and functional recovery after cervical lesion in adult primates

Freund, Patrick ; Schmidlin, Eric ; Wannier, Thierry ; Bloch, Jocelyne ; Mir, Anis ; Schwab, Martin E. ; Rouiller, Eric M.

In: Nature Medicine

In rodents, after spinal lesion, neutralizing the neurite growth inhibitor Nogo-A promotes axonal sprouting and functional recovery. To evaluate this treatment in primates, 12 monkeys were subjected to cervical lesion. Recovery of manual dexterity and sprouting of corticospinal axons were enhanced in monkeys treated with Nogo-A– specific antibody as compared to monkeys treated with control...

Université de Fribourg

A unilateral section of the corticospinal tract at cervical level in Primate does not lead to measurable cell loss in Motor cortex

Wannier, Thierry. ; Schmidlin, Eric ; Bloch, Jocelyne ; Rouiller, Eric M.

In: Journal of Neurotrauma, 2005, vol. 22(6), p. 703

The effects of a unilateral interruption of the dorsolateral funiculus at cervical level on the survival of neurons in the motor cortex were investigated in macaque monkeys. The lesion was made on the left side at the transition region between the 7th and 8th cervical segments, above the motoneurons controlling hand muscles. As a result, the homolateral hand became paretic,...