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A selective ER‐phagy exerts procollagen quality control via a Calnexin‐FAM134B complex

Forrester, Alison ; Leonibus, Chiara De ; Grumati, Paolo ; Fasana, Elisa ; Piemontese, Marilina ; Staiano, Leopoldo ; Fregno, Ilaria ; Raimondi, Andrea ; Marazza, Alessandro ; Bruno, Gemma ; Iavazzo, Maria ; Intartaglia, Daniela ; Seczynska, Marta ; van Anken, Eelco ; Conte, Ivan ; De Matteis, Maria Antonietta ; Dikic, Ivan ; Molinari, Maurizio ; Settembre, Carmine

In: The EMBO Journal, 2019, vol. 38, no. 2, p. e99847

Autophagy is a cytosolic quality control process that recognizes substrates through receptor‐mediated mechanisms. Procollagens, the most abundant gene products in Metazoa, are synthesized in the endoplasmic reticulum (ER), and a fraction that fails to attain the native structure is cleared by autophagy. However, how autophagy selectively recognizes misfolded procollagens in the ER lumen is...

Calnexin, calreticulin, and ERp57 : Teammates in glycoprotein folding

Ellgaard, Lars ; Frickel, Eva-Maria

In: Cell Biochemistry and Biophysics, 2003, vol. 39, no. 3, p. 223-247

ALG9 mannosyltransferase is involved in two different steps of lipid-linked oligosaccharide biosynthesis

Frank, Christian G. ; Aebi, Markus

In: Glycobiology, 2005, vol. 15, no. 11, p. 1156-1163

Ordered assembly of the asymmetrically branched lipid-linked oligosaccharide in the endoplasmic reticulum is ensured by the substrate specificity of the individual glycosyltransferases

Burda, Patricie ; Jakob, Claude A. ; Beinhauer, Jens ; Hegemann, Johannes H. ; Aebi, Markus

In: Glycobiology, 1999, vol. 9, no. 6, p. 617-625

The ALG10 locus of Saccharomyces cerevisiae encodes the α-1,2 glucosyltransferase of the endoplasmic reticulum: the terminal glucose of the lipid-linked oligosaccharide is required for efficient N-linked glycosylation

Burda, Patricie ; Aebi, Markus

In: Glycobiology, 1998, vol. 8, no. 5, p. 455-462