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Université de Fribourg

Yeast ribosomal protein L40 assembles late into pre-60S ribosomes and is required for their cytoplasmic maturation

Fernandez-Pevida, Antonio ; Rodriguez-Galan, Olga ; Diaz-Quintana, Antonio ; Kressler, Dieter ; Cruz, Jesus de la

In: Journal of Biological Chemistry, 2012, p. -

Most ribosomal proteins play important roles in ribosome biogenesis and function. Herein, we have examined the contribution of the essential ribosomal protein L40 in these processes in the yeast Saccharomyces cerevisiae. Deletion of either the RPL40A or RPL40B gene and in vivo depletion of L40 impair 60S ribosomal subunit biogenesis. Polysome profile analyses reveal the accumulation of half-mers...

Université de Fribourg

The power of AAA-ATPases on the road of pre-60S ribosome maturation — Molecular machines that strip pre-ribosomal particles

Kressler, Dieter ; Hurt, Ed ; Bergler, Helmut ; Baßler, Jochen

In: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2011, p. -

The biogenesis of ribosomes is a fundamental cellular process, which provides the molecular machines that synthesize all cellular proteins. The assembly of eukaryotic ribosomes is a highly complex multi-step process that requires more than 200 ribosome biogenesis factors, which mediate a broad spectrum of maturation reactions. The participation of many energy-consuming enzymes (e.g. AAA-type...