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Université de Fribourg

Early effects of carbachol on the morphology of motor endplates of mammalian skeletal muscle fibers

Voigt, Tilman

In: Muscle & Nerve, 2010, vol. 41, no. 3, p. 399 - 405

Long-term disturbance of the calcium homeostasis of motor endplates (MEPs) causes necrosis of muscle fibers. The onset of morphological changes in response to this disturbance, particularly in relation to the fiber type, is presently unknown. Omohyoid muscles of mice were incubated for 1-30 minutes in 0.1 mM carbachol, an acetylcholine agonist that causes an inward calcium current. In these...

Université de Fribourg

Perisynaptic Schwann cells of the vertebrate motor endplate bear modified cilia

Voigt, Tilman ; Dauber, Wolfgang ; Kohler, Ulrike

In: Microscopy Research and Technique, 2004, vol. 63(3), p. 149

Perisynaptic Schwann cells (PSCs), descendants of the myelinating Schwann cells, cover the axon terminal of the vertebrate motor endplate of the skeletal muscle fiber. PSCs are assumed to support the function of the axon terminal. This function suggests a net material transport in the direction of the axon terminal. Morphologically it is to be expected that these cells have a cytoskeleton aligned...