Université de Fribourg

A role for skeletal muscle stearoyl-CoA desaturase 1 in control of thermogenesis

Mainieri, Davide ; Summermatter, Serge ; Seydoux, Josiane ; Montani, Jean-Pierre ; Rusconi, Sandro ; Russell, Aaron P. ; Boss, Olivier ; Buchala, Antony J. ; Dulloo, Abdul G.

In: The FASEB Journal, 2006, vol. 20, no. 10, p. 1751-1753

An enhanced metabolic efficiency for accelerating the recovery of fat mass (or catch-up fat) is a characteristic feature of body weight regulation after weight loss or growth retardation and is the outcome of an "adipose-specific" suppression of thermogenesis, i.e., a feedback control system in which signals from the depleted adipose tissue fat stores exert a suppressive effect on thermogenesis....

Université de Fribourg

Corticotropin-Releasing Hormone directly stimulates thermogenesis in skeletal muscle possibly through substrate cycling between de novo lipogenesis and lipid oxidation

Solinas, Giovanni ; Summermatter, Serge ; Mainieri, Davide ; Gubler, Marcel ; Montani, Jean-Pierre ; Seydoux, Josiane ; Smith, S. R. ; Dulloo, Abdul G.

In: Endocrinology, 2006, vol. 147(1), p. 31-38

The mechanisms by which CRH and related peptides (i.e. the CRH/urocortin system) exert their control over thermogenesis and weight regulation have until now focused only upon their effects on brain centers controlling sympathetic outflow. Using a method that involves repeated oxygen uptake determinations in intact mouse skeletal muscle, we report here that CRH can act directly on skeletal...