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Université de Fribourg

Mitophagy and mitochondria biogenesis are differentially induced in rat skeletal muscles during immobilization and/or remobilization

Deval, Christiane ; Calonne, Julie ; Coudy-Gandilhon, Cécile ; Vazeille, Emilie ; Bechet, Daniel ; Polge, Cécile ; Taillandier, Daniel ; Attaix, Didier ; Combaret, Lydie

In: International Journal of Molecular Sciences, 2020, vol. 21, no. 10, p. 3691

Mitochondria alterations are a classical feature of muscle immobilization, and autophagy is required for the elimination of deficient mitochondria (mitophagy) and the maintenance of muscle mass. We focused on the regulation of mitochondrial quality control during immobilization and remobilization in rat gastrocnemius (GA) and tibialis anterior (TA) muscles, which have very different atrophy...

Université de Fribourg

A new species of Palaeopython (Serpentes) and other extinct squamates from the Eocene of Dielsdorf (Zurich, Switzerland)

Georgalis, Georgios L. ; Scheyer, Torsten M.

In: Swiss Journal of Geosciences, 2019, vol. 112, no. 2, p. 383–417

The lizard and snake fauna from the late middle–late Eocene (MP 16–MP 20) of Dielsdorf, near Zurich, Switzerland, is described comprehensively in this paper. Detailed comparisons of the Dielsdorf material with other extinct taxa allow us to establish a new species of the large “booid” genus Palaeopython, i.e., Palaeopython helveticus sp. nov., characterized by a unique combination of...

Université de Fribourg

Mature lipid droplets are accessible to ER luminal proteins

Mishra, Shirish ; Khaddaj, Rasha ; Cottier, Stéphanie ; Stradalova, Vendula ; Jacob, Claire ; Schneiter, Roger

In: Journal of Cell Science, 2016, vol. 129, no. 20, p. 3803–3815

Lipid droplets are found in most organisms where they serve to store energy in the form of neutral lipids. They are formed at the endoplasmic reticulum (ER) membrane where the neutral-lipid-synthesizing enzymes are located. Recent results indicate that lipid droplets remain functionally connected to the ER membrane in yeast and mammalian cells to allow the exchange of both lipids and integral...

Université de Fribourg

The multiplicity of alternative splicing decisions in Caenorhabditis elegans is linked to specific intronic regulatory motifs and minisatellites

Glauser, Dominique A.

In: BMC Genomics, 2014, vol. 15, no. 1, p. 364

Background: alternative splicing diversifies the pool of messenger RNA molecules encoded by individual genes. This diversity is particularly high when multiple splicing decisions cause a combinatorial arrangement of several alternate exons. We know very little on how the multiple decisions occurring during the maturation of single transcripts are coordinated and whether specific sequence elements...

Université de Fribourg

Notch signaling in the brain: In good and bad times

Alberi, Lavinia ; Hoey, Sarah ; Brai, Emanuele ; Scotti, Alessandra ; Marathe, Swananda

In: Ageing Research Reviews, 2013, p. -

Notch signaling is an evolutionarily conserved pathway, which is fundamental for neuronal development and specification. In the last decade, increasing evidence has pointed out an important role of this pathway beyond embryonic development, indicating that Notch also displays a critical function in the mature brain of vertebrates and invertebrates. This pathway appears to be involved in neural...

Bibliothèque cantonale jurassienne

Micritized skeletal grains in northern Belize lagoon : a major source of mg-calcite mud

Reid, R. Pamela ; Macintyre, Ian G.

In: Journal of sedimentary petrology : a publication of the Society of Economic Palaeontologists and Mineralogists, a division of the American Association of Petroleum Geologists, 1992, vol. 62, no. 1, p. 145