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Université de Fribourg

Ubiquitin release from eL40 is required for cytoplasmic maturation and function of 60S ribosomal subunits in Saccharomyces cerevisiae

Martín‐Villanueva, Sara ; Fernández‐Pevida, Antonio ; Fernández‐Fernández, José ; Kressler, Dieter ; Cruz, Jesús de la

In: The FEBS Journal, 2019, vol. 0, no. 0, p. -

Ubiquitin is generated by proteolytic cleavage of precursor proteins in which it is fused either to itself, constituting a linear polyubiquitin protein of head‐to‐tail monomers, or as a single N‐terminal moiety to one of two ribosomal proteins, eL40 (Ubi1/2 precursors) and eS31 (Ubi3 precursor). It has been proposed that the ubiquitin moiety fused to these ribosomal proteins could act...

Université de Fribourg

Unequivocal signatures of the crossover to Anderson localization in realistic models of disordered quasi-one-dimensional materials

Lopez-Bezanilla, Alejandro ; Froufe-Pérez, Luis S. ; Roche, Stephan ; Sáenz, Juan José

In: Physical Review B, 2018, vol. 98, no. 23, p. 235423

The only unequivocal known criterion for single-parameter scaling Anderson localization relies on the knowledge of the full conductance statistics. To date, theoretical studies have been restricted to model systems with symmetric scatterers, hence lacking universality. We present an in-depth statistical study of conductance distributions P(g), in disordered ‘micrometer-long’ carbon...

Consortium of Swiss Academic Libraries

Tumor-targeting properties of novel immunocytokines based on murine IL1β and IL6

Hess, Christian ; Neri, Dario

In: Protein Engineering, Design & Selection, 2014, vol. 27, no. 6, p. 207-213

Université de Fribourg

Yeast ribosomal protein L40 assembles late into pre-60S ribosomes and is required for their cytoplasmic maturation

Fernandez-Pevida, Antonio ; Rodriguez-Galan, Olga ; Diaz-Quintana, Antonio ; Kressler, Dieter ; Cruz, Jesus de la

In: Journal of Biological Chemistry, 2012, p. -

Most ribosomal proteins play important roles in ribosome biogenesis and function. Herein, we have examined the contribution of the essential ribosomal protein L40 in these processes in the yeast Saccharomyces cerevisiae. Deletion of either the RPL40A or RPL40B gene and in vivo depletion of L40 impair 60S ribosomal subunit biogenesis. Polysome profile analyses reveal the accumulation of half-mers...

Université de Fribourg

Transgenic Arabidopsis plants expressing a fungal cutinase show alterations in the structure and properties of the cuticle and postgenital organ fusions

Sieber, Patrick ; Schorderet, Martine ; Ryser, Ulrich ; Buchala, Antony ; Kolattukudy, Pappachan ; Métraux, Jean-Pierre ; Nawrath, Christiane

In: Plant Cell, 2000, vol. 12, no. 5, p. 721-737

A major structural component of the cuticle of plants is cutin. Analysis of the function of cutin in vivo has been limited because no mutants with specific defects in cutin have been characterized. Therefore, transgenic Arabidopsis plants were generated that express and secrete a cutinase from Fusarium solani f sp pisi. Arabidopsis plants expressing the cutinase in the...