Université de Fribourg

Refined methodology for implantation of a head fixation device and chronic recording chambers in non-human primates

Lanz, Florian ; Lanz, X. ; Scherly, A. ; Moret, Véronique ; Gaillard, A. ; Gruner, P. ; Hoogewoud, Henri-Marcel ; Belhaj-Saif, Abderraouf ; Loquet, Gérard ; Rouiller, Eric M.

In: Journal of Neuroscience Methods, 2013, vol. 219, no. 2, p. 262–270

The present study was aimed at developing a new strategy to design and anchor custom-fitted implants, consisting of a head fixation device and a chronic recording chamber, on the skull of adult macaque monkeys. This was done without the use of dental resin or orthopedic cement, as these modes of fixation exert a detrimental effect on the bone. The implants were made of titanium or tekapeek and...

Université de Fribourg

Direct comparison between properties of adaptation of the auditory nerve and the ventral cochlear nucleus in response to repetitive clicks

Meyer, Kaspar ; Rouiller, Eric M. ; Loquet, Gérard

In: Hearing Research, 2007, vol. 228, no. 1-2, p. 144-155

The present study was designed to complete two previous reports [Loquet, G., Rouiller, E.M., 2002. Neural adaptation to pulsatile acoustical stimulation in the cochlear nucleus of the rat. Hear. Res. 171, 72–81; Loquet, G., Meyer, K., Rouiller, E.M., 2003. Effects of intensity of repetitive acoustic stimuli on neural adaptation in the ventral cochlear nucleus of the rat. Exp. Brain Res. 153,...

Université de Fribourg

Développement d'un modèle expérimental d'implant cochléaire incorporant des propriétés d'adaptation neuronale

Loquet, Gérard ; Rouiller, Eric M. (Dir.)

Thèse de doctorat : Université de Fribourg, 2006.

The research projects reported in the present thesis deal with the auditory function and more specifically the topic dedicated to auditory rehabilitation with a prosthesis implanted into the cochlea: the cochlear implant (CI). Such prosthesis was used for about twenty years and already provides to numerous patients satisfactory conditions, excepted in noisy environment. From the point of view to...

Université de Fribourg

Doxycycline reduces mortality and injury to the brain and cochlea in experimental pneumococcal meningitis

Meli, Damian N. ; Coimbra, Roney S. ; Erhart, Dominik G. ; Loquet, Gérard ; Bellac, Caroline L. ; Täuber, Martin G. ; Neumann, Ulf ; Leib, Stephen L.

In: Infection and Immunity, 2006, vol. 74, no. 7, p. 3890-3896

Bacterial meningitis is characterized by an inflammatory reaction to the invading pathogens that can ultimately lead to sensorineural hearing loss, permanent brain injury, or death. The matrix metalloproteinases (MMPs) and tumor necrosis factor alpha-converting enzyme (TACE) are key mediators that promote inflammation, blood-brain barrier disruption, and brain injury in bacterial meningitis....