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Université de Fribourg

Role of accumbens BDNF and TrkB in cocaine-induced psychomotor sensitization, conditioned-place preference, and reinstatement in rats

Bahi, Amine ; Boyer, Frederic ; Vijay, Chandrasekar ; Dreyer, Jean-Luc

In: Psychopharmacology, 2008, vol. 199, no. 2, p. 169-182

Background Brain-derived neurotrophic factor (BDNF) is involved in the survival and function of midbrain DA neurons. BDNF action is mediated by the TrkB receptor–tyrosine kinase, and both BDNF and TrkB transcripts are widely expressed in the rat mesolimbic pathway, including the nucleus accumbens (NAc) and the ventral tegmentum area (VTA). Objective BDNF was previously shown to be involved in...