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Université de Fribourg

Doublecortin-positive cells in the adult primate cerebral cortex and possible role in brain plasticity and development

Bloch, Jocelyne ; Kaeser, Mélanie ; Sadeghi, Yalda ; Rouiller, Eric M. ; Redmond, D. Eugene JR ; Brunet, Jean-François

In: The Journal of Comparative Neurology, 2011, vol. 519, no. 4, p. 775–789

We have demonstrated that cortical cell autografts might be a useful therapy in two monkey models of neurological disease: motor cortex lesion and Parkinson's disease. However, the origin of the useful transplanted cells obtained from cortical biopsies is not clear. In this report we describe the expression of doublecortin (DCX) in these cells based on reverse-transcription polymerase chain...