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    Université de Fribourg

    Distribution and restoration of serotonin-immunoreactive paraneuronal cells during caudal fin regeneration in zebrafish

    König, Désirée ; Dagenais, Paule ; Senk, Anita ; Djonov, Valentin ; Aegerter, Christof M. ; Jaźwińska, Anna

    In: Frontiers in Molecular Neuroscience, 2019, vol. 12, p. -

    Aquatic vertebrates possess diverse types of sensory cells in their skin to detect stimuli in the water. In the adult zebrafish, a common model organism, the presence of such cells in fins has only rarely been studied. Here, we identified scattered serotonin (5-HT)-positive cells in the epidermis of the caudal fin. These cells were distinct from keratinocytes as revealed by their low...

    Université de Fribourg

    Zebrafish caudal fin angiogenesis assay—advanced quantitative assessment including 3-way correlative microscopy

    Hlushchuk, Ruslan ; Brönnimann, Daniel ; Shokiche, Carlos Correa ; Schaad, Laura ; Triet, Ramona ; Jazwinska, Anna ; Tschanz, Stefan A. ; Djonov, Valentin

    In: PLOS ONE, 2016, vol. 11, no. 3, p. e0149281

    Background: Researchers evaluating angiomodulating compounds as a part of scientific projects or pre-clinical studies are often confronted with limitations of applied animal models. The rough and insufficient early-stage compound assessment without reliable quantification of the vascular response counts, at least partially, to the low transition rate to clinics. Objective: To establish an...