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The Salmonella Spi1 virulence regulatory protein HilD directly activates transcription of the flagellar master operon flhDC

Singer, Hanna M. ; Kühne, Caroline ; Deditius, Julia A. ; Hughes, Kelly T. ; Erhardt, Marc

In: Journal of Bacteriology, 2014, vol. 196, no. 7, p. 1448–1457

Infection of intestinal epithelial cells is dependent on the Salmonella enterica serovar Typhimurium pathogenicity island 1 (Spi1)-encoded type III injectisome system and flagellar motility. Thus, the expression of virulence and flagellar genes is subject to tight regulatory control mechanisms in order to ensure the correct spatiotemporal production of the respective gene products. In this work,...