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Gut Microbial Transformation of the Dietary Imidazoquinoxaline Mutagen MelQx Reduces Its Cytotoxic and Mutagenic Potency

Zhang, Jianbo ; Empl, Michael T. ; Schwab, Clarissa ; Fekry, Mostafa I. ; Engels, Christina ; Schneider, Mirjam ; Lacroix, Christophe ; Steinberg, Pablo ; Sturla, Shana J.

In: Toxicological Sciences, 2017, vol. 159, no. 1, p. 266-276

Synthesis and Structure of a Polymeric Homobimetallic Mercury Compound Constructed from ( E )-Acetyloxy{4-[(pyridin-2-ylmethylene)amino]phenyl}mercury(II)

Basu Baul, Tushar ; Longkumer, Imliwati ; Linden, Anthony

In: Journal of Chemical Crystallography, 2015, vol. 45, no. 8-9, p. 383-390

New Antimicrobial and Biocompatible Implant Coating with Synergic Silver–Vancomycin Conjugate Action

Varisco, Massimo ; Khanna, Nina ; Brunetto, Priscilla S. ; Fromm, Katharina M.

In: ChemMedChem, 2014, vol. 9, no. 6, p. 1221-1230

Materials foreign to the body are used ever more frequently, as increasing numbers of patients require implants. As a consequence, the numbers of implant-related infections have grown as well, and with increasing resistance. Treatments often fail; thus, new antibacterial coating strategies are being developed by scientists to avoid, or at least strongly reduce, bacterial adhesion to implant...

Screening of heteroaromatic scaffolds against cystathionine beta-synthase enables identification of substituted pyrazolo[3,4-c]pyridines as potent and selective orthosteric inhibitors

Fantel, Anna-Maria ; Myrianthopoulos, Vassilios ; Georgoulis, Anastasios ; Lougiakis, Nikolaos ; Zantza, Iliana ; Lamprinidis, George ; Augsburger, Fiona ; Marakos, Panagiotis ; Vorgias, Constantinos E. ; Szabo, Csaba ; Pouli, Nicole ; Papapetropoulos, Andreas ; Mikros, Emmanuel

In: Molecules, 2020, vol. 25, no. 16, p. 3739

Cystathionine β-synthase (CBS) is a key enzyme in the production of the signaling molecule hydrogen sulfide, deregulation of which is known to contribute to a range of serious pathological states. Involvement of hydrogen sulfide in pathways of paramount importance for cellular homeostasis renders CBS a promising drug target. An in-house focused library of heteroaromatic compounds was...

A simple reaction for dna sensing and chemical delivery

Janett, Elia ; Diep, Kim-Long ; Fromm, Katharina M. ; Bochet, Christian G.

In: ACS Sensors, 2020, vol. 5, no. 8, p. 2338–2343

Reactions templated by nucleic acids are currently at the heart of applications in biosensing and drug release. The number of chemical reactions selectively occurring only in the presence of the template, in aqueous solutions, and at room temperature and able to release a chemical moiety is still very limited. Here, we report the use of the p-nitrophenyl carbonate (NPC) as a new reactive...

Preparation of metallosupramolecular single-chain polymeric nanoparticles and their characterization by Taylor dispersion

Neumann, Laura N. ; Urban, Dominic A. ; Lemal, Philipp ; Ramani, Sushila ; Petri-Fink, Alke ; Balog, Sandor ; Weder, Christoph ; Schrettl, Stephen

In: Polymer Chemistry, 2020, vol. 11, no. 2, p. 586–592

Intramolecular cross-linking of polymers can furnish single-chain polymeric nanoparticles (SCPNs), and the use of reversible non-covalent bonds for cross-linking can potentially provide such nanoparticles with stimuli-responsive properties. Here, we report the synthesis of acrylic polymers that carry pendant 2,6-bis(1′-methyl- benzimidazolyl)pyridine ligands, and use these for the...

Correlation of MLCTs of Group 7 fac-[M(CO)3]+ complexes (M = Mn, Re) with bipyridine, pyridinylpyrazine, azopyridine, and pyridin-2-ylmethanimine type ligands for rational photoCORM design

Kottelat, Emmanuel ; Lucarini, Fiorella ; Crochet, Aurélien ; Ruggi, Albert ; Zobi, Fabio

In: European Journal of Inorganic Chemistry, 2019, vol. 2019, no. 33, p. 3758–3768

A mathematical correlation of the MLCT absorption maxima of structurally related fac‐ [M(CO)3L2Br] complexes (M = Mn, Re; L2 = bidentate ligand) is obtained by the comparison of a total of 50 species bearing bipyridine, pyridinylpyrazine, azopyridine and pyridin‐2‐ylmethanimine L2 type ligands. The empirical relationship is first derived by the initial comparison of the MLCT absorption...

On the sustainability of photochemical reactions

Bochet, Christian G.

In: CHIMIA International Journal for Chemistry, 2019, vol. 73, no. 9, p. 720–723

Photochemical reactions are often presented as intrinsically environmentally friendly ('green'). This may be indeed the case, but only in particular circumstances. This short essay comments on various aspects of the greenness of photochemical reactions, both in a historical (when only mercury-based hard UV light sources were available) and a current (with the recent introduction of LED...

Anion-induced structural diversity of Zn and Cd coordination polymers based on bis-9,10-(pyridine-4-yl)-anthracene, their luminescent properties, and highly efficient sensing of nitro derivatives and herbicides

Vasylevskyi, Serhii I. ; Bassani, Dario M. ; Fromm, Katharina M.

In: Inorganic Chemistry, 2019, vol. 58, no. 9, p. 5646–5653

Luminescent coordination polymers (CPs) of Zn2+ or Cd2+ and bis-9,10-(pyridine-4- yl)-anthracene (BA) show different 1D and 2D topologies depending on the anion used in the precursor. Compounds {[Zn(μ2-BA)(MeOH)2(p-Tos)2]}n (1) and {[Zn(μ2- BA)(MeOH)2(CF3CO2)2]}n (2) form linear structures and {BA@[Zn(μ2-BA) (MeOH)2(H2O)2](CF3SO3)2}n (3) featuring intercalation of uncoordinated BA molecules...

Malonylation/Decarbalkoxylation of Furan Derivatives as Key Steps for the Preparation of Nonactic Acid Derivatives. Part II [1]

Simone, Jean-Mary ; Loiseau, François ; Carcache, David ; Bobal, Pavel ; Jeanneret-Gris, Julie ; Neier, Reinhard

In: Monatshefte für Chemie - Chemical Monthly, 2007, vol. 138, no. 2, p. 141-147