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Ubiquitin-specific protease USP2-45 acts as a molecular switch to promote α2δ-1-induced downregulation of Cav1.2 channels

Rougier, Jean-Sebastien ; Albesa, Maxime ; Syam, Ninda ; Halet, Guillaume ; Abriel, Hugues ; Viard, Patricia

In: Pflügers Archiv - European Journal of Physiology, 2015, vol. 467, no. 9, p. 1919-1929

Suppression of Sleep Spindle Rhythmogenesis in Mice with Deletion of CaV3.2 and CaV3.3 T-type Ca2+ Channels

Pellegrini, Chiara ; Lecci, Sandro ; Lüthi, Anita ; Astori, Simone

In: Sleep, 2016, vol. 39, no. 4, p. 875-885

Specific ion channels control sensory gain, sensitivity, and kinetics in a tonic thermonociceptor

Saro, Gabriella ; Lia, Andrei-Stefan ; Thapliyal, Saurabh ; Marques, Filipe ; Busch, Karl Emanuel ; Glauser, Dominique A.

In: Cell Reports, 2020, vol. 30, no. 2, p. 397-408.e4

Pain sensation and aversive behaviors entail the activation of nociceptor neurons, whose function is largely conserved across animals. The functional heterogeneity of nociceptors and ethical concerns are challenges for their study in mammalian models. Here, we investigate the function of a single type of genetically identified C. elegans thermonociceptor named FLP. Using calcium imaging in...

Ubiquitin release from eL40 is required for cytoplasmic maturation and function of 60S ribosomal subunits in Saccharomyces cerevisiae

Martín‐Villanueva, Sara ; Fernández‐Pevida, Antonio ; Fernández‐Fernández, José ; Kressler, Dieter ; Cruz, Jesús de la

In: The FEBS Journal, 2019, vol. 0, no. 0, p. -

Ubiquitin is generated by proteolytic cleavage of precursor proteins in which it is fused either to itself, constituting a linear polyubiquitin protein of head‐to‐tail monomers, or as a single N‐terminal moiety to one of two ribosomal proteins, eL40 (Ubi1/2 precursors) and eS31 (Ubi3 precursor). It has been proposed that the ubiquitin moiety fused to these ribosomal proteins could act...

Adjuvants and the vaccine response to the DS-Cav1-stabilized fusion glycoprotein of respiratory syncytial virus

Sastry, Mallika ; Zhang, Baoshan ; Chen, Man ; Joyce, M. Gordon ; Kong, Wing-Pui ; Chuang, Gwo-Yu ; Ko, Kiyoon ; Kumar, Azad ; Silacci, Chiara ; Thom, Michelle ; Salazar, Andres M. ; Corti, Davide ; Lanzavecchia, Antonio ; Taylor, Geraldine ; Mascola, John R. ; Graham, Barney S. ; Kwong, Peter D.

In: Plos one, 2017, vol. 12, no. 10, p. e0186854

Appropriate adjuvant selection may be essential to optimize the potency and to tailor the immune response of subunit vaccines. To induce protective responses against respiratory syncytial virus (RSV)—a highly prevalent childhood pathogen without a licensed vaccine—we previously engineered a pre-fusion-stabilized trimeric RSV F (pre-F) “DS-Cav1” immunogen, which induced high titer...

The CNGCb and CNGCd genes from Physcomitrella patens moss encode for thermosensory calcium channels responding to fluidity changes in the plasma membrane

Finka, Andrija ; Goloubinoff, Pierre

In: Cell Stress and Chaperones, 2014, vol. 19, no. 1, p. 83-90

A low-power transmission-gate-based 16-bit multiplier for digital hearing aids

Carbognani, Flavio ; Buergin, Felix ; Felber, Norbert ; Kaeslin, Hubert ; Fichtner, Wolfgang

In: Analog Integrated Circuits and Signal Processing, 2008, vol. 56, no. 1-2, p. 5-12

Novel CACNA1A mutation(s) associated with slow saccade velocities

Kipfer, Stefan ; Jung, Simon ; Lemke, Johannes ; Kipfer-Kauer, Anna ; Howell, Jeremy ; Kaelin-Lang, Alain ; Nyffeler, Thomas ; Gutbrod, Klemens ; Abicht, Angela ; Müri, René

In: Journal of Neurology, 2013, vol. 260, no. 12, p. 3010-3014

Modeling the pore structure of voltage-gated sodium channels in closed, open, and fast-inactivated conformation reveals details of site 1 toxin and local anesthetic binding

Scheib, Holger ; McLay, Iain ; Guex, Nicolas ; Clare, Jeff ; Blaney, Frank ; Dale, Tim ; Tate, Simon ; Robertson, Graeme

In: Journal of Molecular Modeling, 2006, vol. 12, no. 6, p. 813-822

Gating Properties of a Sodium Channel with Three Arginines Substituted by Histidines in the Central Part of Voltage Sensor S4D4

Kühn, F. ; Greeff, N.

In: The Journal of Membrane Biology, 2003, vol. 193, no. 1, p. 23-34