Perfeziona i miei risultati

Parkin functionally interacts with PGC-1α to preserve mitochondria and protect dopaminergic neurons

Zheng, Lu ; Bernard-Marissal, Nathalie ; Moullan, Norman ; D'Amico, Davide ; Auwerx, Johan ; Moore, Darren J. ; Knott, Graham ; Aebischer, Patrick ; Schneider, Bernard L.

In: Human Molecular Genetics, 2017, vol. 26, no. 3, p. 582-598

Effects of the Mitochondrial and Nuclear Genomes on Nonshivering Thermogenesis in a Wild Derived Rodent

Bize, Pierre ; Lowe, Imogen ; Lehto Hürlimann, Mikko ; Heckel, Gerald

In: Integrative and Comparative Biology, 2018, vol. 58, no. 3, p. 532-543

Hepatocellular Toxicity of Imidazole and Triazole Antimycotic Agents

Haegler, Patrizia ; Joerin, Lorenz ; Krähenbühl, Stephan ; Bouitbir, Jamal

In: Toxicological Sciences, 2017, vol. 157, no. 1, p. 183-195

Proteasomal degradation induced by DPP9-mediated processing competes with mitochondrial protein import

Finger, Yannik ; Habich, Markus ; Gerlich, Sarah ; Urbanczyk, Sophia ; Logt, Erik ; Koch, Julian ; Schu, Laura ; Lapacz, Kim Jasmin ; Ali, Muna ; Petrungaro, Carmelina ; Salscheider, Silja Lucia ; Pichlo, Christian ; Baumann, Ulrich ; Mielenz, Dirk ; Dengjel, Jörn ; Brachvogel, Bent ; Hofmann, Kay ; Riemer, Jan

In: The EMBO Journal, 2020, vol. 39, no. 19, p. e103889

Plasticity of the proteome is critical to adapt to varying conditions. Control of mitochondrial protein import contributes to this plasticity. Here, we identified a pathway that regulates mitochondrial protein import by regulated N-terminal processing. We demonstrate that dipeptidyl peptidases 8/9 (DPP8/9) mediate the N-terminal processing of adenylate kinase 2 (AK2) en route to mitochondria....

Mitophagy and mitochondria biogenesis are differentially induced in rat skeletal muscles during immobilization and/or remobilization

Deval, Christiane ; Calonne, Julie ; Coudy-Gandilhon, Cécile ; Vazeille, Emilie ; Bechet, Daniel ; Polge, Cécile ; Taillandier, Daniel ; Attaix, Didier ; Combaret, Lydie

In: International Journal of Molecular Sciences, 2020, vol. 21, no. 10, p. 3691

Mitochondria alterations are a classical feature of muscle immobilization, and autophagy is required for the elimination of deficient mitochondria (mitophagy) and the maintenance of muscle mass. We focused on the regulation of mitochondrial quality control during immobilization and remobilization in rat gastrocnemius (GA) and tibialis anterior (TA) muscles, which have very different atrophy...

Overproduction of H2S, generated by CBS, inhibits mitochondrial Complex IV and suppresses oxidative phosphorylation in Down syndrome

Panagaki, Theodora ; Randi, Elisa B. ; Augsburger, Fiona ; Szabo, Csaba

In: Proceedings of the National Academy of Sciences, 2019, p. 201911895

Down syndrome (DS) is associated with significant perturbances in mitochondrial function. Here we tested the hypothesis that the suppression of mitochondrial electron transport in DS cells is due to high expression of cystathionine-β-synthase (CBS) and subsequent overproduction of the gaseous transmitter hydrogen sulfide (H2S). Fibroblasts from DS individuals showed higher CBS expression...

Parvalbumin expression in oligodendrocyte-like CG4 cells causes a reduction in mitochondrial volume, attenuation in reactive oxygen species production and a decrease in cell processes’ length and branching

Lichvarova, Lucia ; Blum, Walter ; Schwaller, Beat ; Szabolcsi, Viktoria

In: Scientific Reports, 2019, vol. 9, no. 1, p. 10603

Forebrain glial cells - ependymal cells and astrocytes -acquire upon injury- a “reactive” phenotype associated with parvalbumin (PV) upregulation. Since free radicals, e.g. reactive oxygen species (ROS) play a role in the pathogenesis of multiple sclerosis, and that PV-upregulation in glial cells is inversely correlated with the level of oxidative stress, we hypothesized that...

Hypoxia refines plasticity of mitochondrial respiration to repeated muscle work

Desplanches, Dominique ; Amami, Myriam ; Dupré-Aucouturier, Sylvie ; Valdivieso, Paola ; Schmutz, Silvia ; Mueller, Matthias ; Hoppeler, Hans ; Kreis, Roland ; Flück, Martin

In: European Journal of Applied Physiology, 2014, vol. 114, no. 2, p. 405-417

Pathophysiological mechanisms of catecholamine and cocaine-mediated cardiotoxicity

Liaudet, Lucas ; Calderari, Belinda ; Pacher, Pal

In: Heart Failure Reviews, 2014, vol. 19, no. 6, p. 815-824

P2Y2 receptor activation inhibits the expression of the sodium-chloride cotransporter NCC in distal convoluted tubule cells

Gailly, P. ; Szutkowska, M. ; Olinger, E. ; Debaix, H. ; Seghers, F. ; Janas, S. ; Vallon, V. ; Devuyst, O.

In: Pflügers Archiv - European Journal of Physiology, 2014, vol. 466, no. 11, p. 2035-2047