In: Human Molecular Genetics, 2017, vol. 26, no. 3, p. 582-598
|
In: Integrative and Comparative Biology, 2018, vol. 58, no. 3, p. 532-543
|
In: Toxicological Sciences, 2017, vol. 157, no. 1, p. 183-195
|
In: The EMBO Journal, 2020, vol. 39, no. 19, p. e103889
Plasticity of the proteome is critical to adapt to varying conditions. Control of mitochondrial protein import contributes to this plasticity. Here, we identified a pathway that regulates mitochondrial protein import by regulated N-terminal processing. We demonstrate that dipeptidyl peptidases 8/9 (DPP8/9) mediate the N-terminal processing of adenylate kinase 2 (AK2) en route to mitochondria....
|
In: International Journal of Molecular Sciences, 2020, vol. 21, no. 10, p. 3691
Mitochondria alterations are a classical feature of muscle immobilization, and autophagy is required for the elimination of deficient mitochondria (mitophagy) and the maintenance of muscle mass. We focused on the regulation of mitochondrial quality control during immobilization and remobilization in rat gastrocnemius (GA) and tibialis anterior (TA) muscles, which have very different atrophy...
|
In: Proceedings of the National Academy of Sciences, 2019, p. 201911895
Down syndrome (DS) is associated with significant perturbances in mitochondrial function. Here we tested the hypothesis that the suppression of mitochondrial electron transport in DS cells is due to high expression of cystathionine-β-synthase (CBS) and subsequent overproduction of the gaseous transmitter hydrogen sulfide (H2S). Fibroblasts from DS individuals showed higher CBS expression...
|
In: Scientific Reports, 2019, vol. 9, no. 1, p. 10603
Forebrain glial cells - ependymal cells and astrocytes -acquire upon injury- a “reactive” phenotype associated with parvalbumin (PV) upregulation. Since free radicals, e.g. reactive oxygen species (ROS) play a role in the pathogenesis of multiple sclerosis, and that PV-upregulation in glial cells is inversely correlated with the level of oxidative stress, we hypothesized that...
|
In: European Journal of Applied Physiology, 2014, vol. 114, no. 2, p. 405-417
|
In: Heart Failure Reviews, 2014, vol. 19, no. 6, p. 815-824
|
In: Pflügers Archiv - European Journal of Physiology, 2014, vol. 466, no. 11, p. 2035-2047
|