In: Nature Communications, 2020, vol. 11, no. 1, p. 3420
Remyelination of the peripheral and central nervous systems (PNS and CNS, respectively) is a prerequisite for functional recovery after lesion. However, this process is not always optimal and becomes inefficient in the course of multiple sclerosis. Here we show that, when acetylated, eukaryotic elongation factor 1A1 (eEF1A1) negatively regulates PNS and CNS remyelination. Acetylated eEF1A1...
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In: Genome Research, 2020, vol. 30, no. 1, p. 127-137
Bone marrow–derived mesenchymal stem cells (MSCs) differentiate into osteoblasts upon stimulation by signals present in their niche. Because the global signaling cascades involved in the early phases of MSCs osteoblast (OB) differentiation are not well-defined, we used quantitative mass spectrometry to delineate changes in human MSCs proteome and phosphoproteome during the first 24 h of...
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In: Cell reports, 2016, vol. 15, no. 7, p. 1566-1579
Dioxygenases of the TET family impact genome functions by converting 5-methylcytosine (5mC) in DNA to 5-hydroxymethylcytosine (5hmC). Here, we identified TET2 as a crucial regulator of mast cell differentiation and proliferation. In the absence of TET2, mast cells showed disrupted gene expression and altered genome-wide 5hmC deposition, especially at enhancers and in the proximity of...
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In: Nature communications, 2018, vol. 9, p. 4016
DNA end resection plays a critical function in DNA double-strand break repair pathway choice. Resected DNA ends are refractory to end-joining mechanisms and are instead channeled to homology-directed repair. Using biochemical, genetic, and imaging methods, we show that phosphorylation of Saccharomyces cerevisiae Sae2 controls its capacity to promote the Mre11-Rad50-Xrs2 (MRX) nuclease to...
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In: Basic Research in Cardiology, 2014, vol. 109, no. 1, p. 1-15
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In: Chromosoma, 2014, vol. 123, no. 5, p. 423-436
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In: Cellular and Molecular Life Sciences, 2014, vol. 71, no. 8, p. 1453-1467
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In: Frontiers in Genetics, 2013, vol. 4, p. -
An animal’s survival strongly depends on its ability to maintain homeostasis in response to the changing quality of its external and internal environment. This is achieved through intracellular and intercellular communication within and among different tissues. One of the organ systems that plays a major role in this communication and the maintenance of homeostasis is the nervous system....
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In: Chromosoma, 2009, vol. 118, no. 2, p. 141-151
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In: Plant Molecular Biology, 1998, vol. 38, no. 5, p. 785-795
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